2013 ISPAM Mid-Year Mtg Book

3. 32 Quantitative Method - a method of analysis whose response is the amount of the analyte measured either directly (e.g., enumeration in a mass or volume), or indirectly (e.g., colour absorbance, impedance, etc) in a certain amount of sample. 3. 43 Qualitative Method - is a method of analysis whose response is either the presence or absence of the analyte detected either directly or indirectly in a certain amount of sample. 3. 54 Repeatability (r) – mM easurement precision under a set of repeatability conditions of measurement; the condition of measurement , out of a set of conditions , that includes the same measurement procedure, same operators, same measuring system, same operating conditions, and same location, and replicate measurements on the same or similar objects over a short period of time. A condition of measurement is a repeatability the precision with which repeat measurements of the same sample give the same value with all conditions unchanged between measurements, except time. The closeness of agreement between individual results, using the same method, test substance, and set of laboratory conditions. This represent a measurement done with the least amount of variability Repeatability is a measure of precision, not accuracy. Altermative version: The closeness of agreement between individual results, using the same method, test substance, and set of laboratory conditions. Measurement precision under a set of repeatability conditions of measurement; the condition of measurement, out of a set of conditions, that includes the same measurement procedure, same operators, same measuring system, same operating conditions, and same location, and replicate measurements on the same or similar objects over a short 3. 65 measurement precision under reproducibility conditions of measurement; a condition of measurement out of a set of conditions that includes different locations, operators, measuring systems, and replicate measurements on the same or similar objects. the closeness of the agreement between the results of measurements of the same analyte, where the measurements are carried out under changed conditions. Usually used to imply agreement within a method as applied among different laboratories Change all you can change to generate the maximum amount of variability 3. 76 Verification - the provision of objective evidence that a given item fulfills specified requirements or to assess the performance of a method in the own laboratory situation against the specifications of the method established during the validation study. The laboratory must demonstrate that it is capable of performing the analysis. 3.7 Familiarization: 4. Verification for qualitative and quantitative methods Verification is required when a new method is implemented in a laboratory or when a method is updated (new version is published) . The verification process includes: Reproducibility (R): period of time. A condition of measurement is a repeatability This represent a measurement with the least amount of variability Repeatability is a measure of precision, not accuracy.

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Comment [ii2]: ACTION: TG TO CHOSE PREFERED DEFINITION

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Comment [ii3]: Daniel to input explantion Formatted: Indent: First line: 0" Formatted: Highlight

Comment [ii4]: Daniel to input explantion Formatted: Highlight Formatted: Highlight

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Comment [L5]: Daniel to draft explanatory/interpretive note: one intra-lab repro. study + PT panel Comment [L6]: TBD: a) will definitions stay here + note in following section b) definitions + note here c) no definition section, everything later?

Comment [ii7]: ACTION: Shelagh to draft a definition

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