2018 August 26 SPSFAM Book

Current Methods for FDAMycotoxin Analysis

References: 1. AOAC 991.31; FDA Kansas Lab SOP: KAN-LAB-MYC.45 2. J AOAC Int. 1996, 79(4):883-7; FDA Kansas Lab SOP: KAN-LAB-MYC.41 3. AOAC 49.6.05/06; 49.5.01/03; FDA Kansas Lab SOP; KAN-LAB-MYC.42 4. AOAC 2001.04; FDA Kansas Lab SOP: KAN-LAB-MYC.43 5. AOAC 49.6.02; AOAC 49.7.03; FDA Kansas Lab SOP: KAN-LAB-MYC.44 6. FDA Compliance Program Guidance Manual. Chapter 7, “…Sample milk for aflatoxin M 1

if state coverage is inadequate…”

Which Mycotoxins Should be Targeted?

Group I: mycotoxins with regulatory action/guidance levels Aflatoxins, Deoxynovialenol, Fumonisins, Ochratoxin A a , Patulin (reference standards and 13 C-IS available) a The FDA has not established an action level for ochratoxin A but any positive finding above 20 ppb should be reported. Group II: mycotoxins of health importance but without regulatory action/guidance levels Citrinin, Ergot alkaloids, T-2 & HT-2 toxins, Zearelenone… (reference standards available; 13 C-IS only available for a few) Group III: mycotoxins of common interest without regulatory action/guidance levels (reference standards may not be available)