2018 Sugar ERP - Method Review Book

2. Does the method contain system suitability tests or controls as specified by the SMPR? If not, please indicate if there is a need for such tests or controls and which ones. 3. Is there information demonstrating that the method system suitability tests and controls as specified in the SMPR worked appropriately and as expected? If no, please specify. 4. Based on the supporting information, is the method written clearly and concisely? If no, please specify the needed revisions. 5. Based on the supporting information, what are the pros/strengths of the method? 6. Based on the supporting information, what are the cons/weaknesses of the method?

Some. Includes check standards but no blanks.

Yes. Linearity and residuals listed.

Yes.

Definite improvement to many existing methods. Clearly lays out many known close eluting peaks as well as the potential need for additional (optional) sample cleanup.

For samples containing inherent arabinose (i.e., coffee and coffee flavored beverages) there is no direction on how testing results are impacted.

7. Any general comments about the method?

I applaud the authors on what a comprehensive data set they have assembled and submitted. This was truly a tremendous undertaking.

V. Final Recommendation Do you recommend this method be adopted as a First Action and published in the Official Methods of Analysis of AOAC INTERNATIONAL? Please specify rationale.

Yes, with 2 caveats.

1. Provide additional clarification for contingencies in samples that do contain arabinose (I recommend embedding as system suitability criterion linking a ratio for the IS area in samples to the IS area in standards or something similar). 2. I'm hesitant to recommend this method for isomaltulose on the basis of some of the aberrant data. I would suggest perhaps only moving the other 6 analytes forward and perform some additional optimization on isomaltulose.