2019 AOAC Annual Meeting - Preliminary Program

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September 6– 12, 2019 | Denver, Colorado 133 rd Annual Meeting & Exposition




5 Welcome from the President of AOAC INTERNATIONAL 6 Schedule at a Glance 8 Keynote Address 9 H.W. Wiley Award Address 11 Education & Stakeholder Panels 12 Training Courses 15 Exposition & Exhibitor/Par tner Presentation Information

17 Scientific Sessions 28 Poster Presentations 35 Special Events 37 Meeting & Travel Information 38 Denver Information 40 Registration Information

AOAC INTERNATIONAL is a globally recognized, 501(c)(3), independent, third party, not-for-profit association and voluntary consensus standards developing organization founded in 1884. When analytical needs arise within a community or industry, AOAC INTERNATIONAL is the forum for finding appropriate science-based solutions through the development of microbiological and chemical standards. AOAC standards are used globally to promote trade and to facilitate public health and safety.

**AOAC will NOT have a printed Final Program. All information will be on the Annual Meeting mobile app available for download in August and on www.aoac.org.


Meet top experts and keep pace with innovation in methods-based science at the 133 rd AOAC INTERNATIONAL Annual Meeting. This once a year event is where the food science analytical community comes together to share knowledge and forge business-building collaborations. Be part of the event that will shape the initiatives in 2020 and beyond. The AOAC Annual Meeting: NEW SCIENCE. NEW LEADERS. NEWOPPORTUNITIES.


NETWORK FOR SUCCESS WI TH OTHER COL LABORAT I VE PROFESS IONAL S With more than 850 attendees from global industry, government and academia, the AOAC Annual Meeting is a unique opportunity to build professional networks: • Networking receptions, including an orientation and a reception for new members and first-time attendees • Attendees from all over the world and 17 AOAC Sections including China, Taiwan, Japan, Europe, Sub-Saharan Africa, Latin America, and North America • 60 exhibitors , from the private sector, nonprofits, and government agencies JOIN THE COMMUNI T Y AT THE AOAC ANNUAL MEET ING • Businesses gain access to scientific and regulatory experts, and the opportunity to shape trends and standards that get adopted. • Scientists build their professional expertise and access a community of like-minded individuals to share information and best practices with. • Regulators join an unprecedented forum for collaboration with stakeholders on complex testing and analysis challenges, helping improve compliance and public safety.

In an innovative and diverse industry, new food safety challenges are always on the horizon. At this year’s Annual Meeting, AOAC introduces the Analytical Solutions Forum , a multi-faceted “idea incubator” focusing on preparing for regulatory changes and emerging food safety issues. In a plenary and two breakout sessions, join thought-provoking discussions on how to identify and meet analytical needs—before public health emergencies arise. EXPAND YOUR EXPERT I SE IN A KNOWL EDGE -CENTERED INDUSTRY This year’s meeting includes 29 scientific sessions on emerging methods, best practices, and trending topics like food fraud and cannabis purity and potency. Discover new technologies from DNA authentication to genomic microbial identification and get expert insights through: • More than 250 poster presentations • AOAC Stakeholder panel and working group meetings • Three training courses (fee-based) • “AOAC Spotlight”— insiders share professional insights in short, informal talks

The future of food happens at the AOAC Annual Meeting. Be part of the conversation – Register now!

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ACKNOWLEDGMENTS 2018-19 AOAC TECHNICAL PROGRAMMING COUNCI L AOAC wishes to express its sincere thanks to the members of the Technical Programming Council for their efforts in devel- oping and coordinating the technical program for this year’s Annual Meeting. Alexander Krynitsky, Chair Symbiotic Research LLC Jane Weitzel, Member Independent Consultant

Michael McLaughlin, Vice Chair U.S. Food and Drug Administration, ORS/ORA

John Szpylka, Member Mérieux NutriSciences

Patrick Bird, Member PBM Biotek Consulting

Jian Wang, Member Canadian Food Inspection Agency

Aniko Solyom, Member GAAS Analytical

Melissa Phillips, Member U.S. National Institute of Standards and Technology

Carmen Diaz-Amigo, Member FOCOS GbR

Erin Crowley, Ex-Officio Member Q Laboratories, Inc.

2018-19 AOAC INTERNAT IONAL BOARD OF DIREC TORS Brad Goskowicz, President Microbiologics, Inc. Saint Cloud, MN, USA Lei Bao, Director Nestlé Food Safety Institute Beijing, Peoples Republic of China

Daniel S. Fabricant, Director at Large Natural Products Association Washington, DC, USA John Szpylka, Director at Large Mérieux Nutrisciences Chicago, IL, USA Stephen A. Wise, Director at Large U.S. National Institutes of Health, Office of Dietary Supplements (Retired) Bethesda, MD, USA

DeAnn Benesh, Past President 3M Food Safety Saint Paul, MN, USA

Michael Brodsky, Director Brodsky Consultants Thornhill, Ontario, CANADA Clay Detlefson, Director National Milk Producers Federation Arlington, VA, USA Samuel Benrejeb Godefroy, Director University Laval Quebec City, Canada Anthony J. Lupo, Director Neogen Corporation Lansing, MI, USA

Henry Chin, President - Elect Moraga, CA, USA

Jonathan W. DeVries, Treasurer Medallion Laboratories/ General Mills (Retired) Minneapolis, MN, USA

David B. Schmidt, Executive Director AOAC INTERNATIONAL Rockville, MD, USA

Darryl M. Sullivan, Secretary Eurofins – Food Integrity and Innovation Madison, WI, USA



On behalf of the entire Board of Directors and staff of AOAC INTERNATIONAL, I am pleased to welcome you to the 133rd AOAC

AOAC Annual Meeting and Exposition. In his address, “Nature Exposed to Our Method of Questioning: Reliability of Measurements Made on Natural Products,” Betz will examine the principles of assuring data integrity and provide an overview of approaches to demonstrating method performance. He will stress the importance of determining integrity and reproducibility in natural products research for precise and accurate analysis. AOAC is excited to offer three valuable training courses for our members and stakeholders at this year’s meet- ing. Don’t miss out on courses for ISO 17025:2017 Standard, sampling, and laboratory validation. The course offerings align with AOAC’s commitment to develop and enhance core programs. I would like to take this opportunity to especially thank our sponsors, partners, and exhibitors for supporting the meeting. Be sure to check out the impressive collection of exhibits and the many networking events supported by these companies. From education and stakeholder programs, 29 scientific sessions, 12 poster topic areas, Sections and commit- tee meetings, and much more, I encourage you to take full advantage of all the opportunities that the AOAC Annual Meeting has to offer. Meet and learn from internationally renowned scientists who are making a difference in their field. Examine the latest scientific research and technological advancements. Explore challenges and find opportunities for the association and the analytical sciences community it serves. I look forward to seeing you at the Exhibit Hall Grand Opening and President’s Welcome Reception on Sunday evening, September 9, to kick off the 133rd AOAC Annual Meeting and Exposition!

Annual Meeting and Exposition in Denver, Colorado. Some of the greatest minds, talents, innovations, and science are found at this annual event.

What a difference a year makes! Our business plan is well underway as we start a new chapter in AOAC INTERNATIONAL’s history, and I am looking forward to sharing our progress in Denver. This year, AOAC launched programs to align with our strategic plan, with an eye toward new approaches to looking at emerging issues and technologies and building closer relationships with stakeholders. We are excited for you to visit the Mile High City and learn about the big things happening at AOAC like the new Analytical Solutions Forum, Cannabis Analytical Science Program, and Food Authenticity/Fraud Program, just to name a few. AOAC is honored to announce this year’s invited keynote speaker Mindy M. Brashears, Deputy Under Secretary for Food Safety, U.S. Department of Agriculture. As a deputy under secretary, Brashears leads the USDA’s Food Safety and Inspection Service. The group’s mission is to protect the public’s health by preventing foodborne illness; modernizing inspection systems, policies and approaches; and achieving oper- ational excellence. This year’s winner of the Harvey W. Wiley award, Joseph M. Betz, acting director, U.S. National Institutes of Health-Office of Dietary Supplements, will deliver the Wiley Award Address and chair the Wiley Award Symposium on September 9, 2019, during the 133rd


Brad Goskowicz President AOAC INTERNATIONAL

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10:15am – 10:45am 10:30am – 11:00am 11:00am – 12:00pm 11:15am – 11:45am 12:00pm – 1:00pm 12:15pm – 12:45pm 1:00pm – 1:30pm 1:30pm – 3:00pm

Partner Presentation: Eurofins

Refreshment Break

8:00am – 5:00pm 9:00am – 5:00pm


Exhibitor/Partner Presentation: Thermo Fisher Scientific

Food Authenticity/Fraud Program

Exhibitor/Partner Presentation: Shimadzu

Poster Author Presentations

SATURDAY, SEPTEMBER 7, 2019 7:30am – 5:00pm Registration 8:30am – 12:00pm

Exhibitor/Partner Presentation: Megazyme

Wiley Award Address

Wiley Award Symposium: Advances in Analytical Methods for Botanical Dietary Supplements and for Clinical Nutritional Assessment Symposium: Recent Trends in Elemental Analysis Applications Roundtable: Method Fitness in a Time of FSMA - How Should Laboratories and Food Manufacturers Decide on Method Suitability? AOAC Working Group on Quantitative Microbiology Method Acceptance Criteria Symposium: Application of DNA Technologies and Standards in the Authentication of Botanicals for Quality Control of Botanical Dietary Supplements Symposium: Multi-Class/Multi-Residue Veterinary Drug Methods — Which Strategies and for What Purpose? Symposium: Microbial Identification with Genomics and Proteomics in Food and Dietary Supplements AOAC Expert Review Panel for Microbiology Methods for Food and Environmental Surfaces Exhibitor Presentation: bioMérieux Refreshment Break

AOAC Stakeholder Panel on Infant Formula and Adult Nutritional (SPIFAN) Meeting Training Course: Guidance on Obtaining Defensible Test Portions — Subsampling for Analytical Laboratories Training Course: AOAC/A2LA ISO/IEC 17025:2017 Bridging the Gap from 2005 (MS 110)

9:00am – 5:00pm

1:30pm – 3:00pm

9:00am – 5:00pm

1:30pm – 3:00pm

9:00am – 5:00pm 1:00pm – 5:00pm 5:00pm – 6:00pm

Cannabis Analytical Science Program (CASP)

1:30pm – 3:30pm

AOAC Expert Review Panel on SPIFAN Nutrient Methods

AOAC Networking Reception

3:00pm – 3:30pm 3:00pm – 3:30pm 3:30pm – 5:00pm

SUNDAY, SEPTEMBER 8 , 2019 7:30am – 8:00pm Registration 8:30am – 2:30pm Analytical Solutions Forum 9:00am – 5:00pm

3:30pm – 5:00pm

Training Course: Guidance on Obtaining Defensible Test Portions — Subsampling for Analytical Laboratories

3:30pm – 5:00pm

10:00am – 12:00pm 10:00am – 12:00pm 1:00pm – 2:30pm

Analytical Solutions Forum Break Out Session #1

4:00pm – 8:00pm

Analytical Solutions Forum Break Out Session #2

TDRM Training Course: Selection and Use of Reference Materials TDLM/TDRM Workshop: What Auditors are Seeing as Top Findings for Laboratories Being Accredited to the ISO/IEC 17025:2017 Standard

5:00pm – 5:30pm 5:00pm – 6:00pm 5:00pm – 6:30pm

Exhibitor Presentation: Phenomenex

Color Additives Meeting

3:00pm – 4:30pm

New Member and First-Time Attendee Welcoming Reception, Sponsored by Abbott Nutrition

5:00pm – 6:30pm 5:00pm – 7:00pm

ALACC Meeting

3:00pm – 5:00pm 3:00pm – 5:00pm 4:00pm – 4:45pm

AOAC Working Group on Furans

Chemical Contaminants and Residues in Food Community Meeting

AOAC INTERNATIONAL Board of Directors Meeting

New Member and First Time Meeting Attendee Orientation Exhibit Hall Grand Opening & President's Welcome Reception

6:00pm – 7:00pm 6:00pm – 7:00pm 6:30pm – 7:30pm

Taiwan Section Business Meeting

Japan Section Business Meeting

7:00pm – 9:00pm

Reception for TDLM Members, Co-Sponsored by Microbiologics

7:00 pm – 8:00 pm

Joint Asian Sections Business Meeting

MONDAY, SEPTEMBER 9, 2019 7:15am – 8:15am TDRM Executive Committee Meeting 7:30am – 5:00pm Registration 7:30am – 8:00am

TUESDAY, SEPTEMBER 10 , 2019 7:00am – 8:00am

Exhibitor/Partner Presentation: Waters Corporation

Exhibitor/Partner Presentation: Pickering Laboratories

7:30am – 5:00pm 7:45am – 8:15am 8:00am – 12:00pm 8:15am – 9:45am


8:00am – 8:30am 8:30am – 10:00am 10:00am – 11:00am 10:00am – 11:30am 10:00am – 1:00pm 10:00am – 5:00pm

Continental Breakfast

Refreshment Break

Keynote Address and Awards Ceremony

AOAC Standards and Methods Orientation

Latin America Section Business Meeting

Symposium: Applying Non-Target Data Acquisition for Target Analysis (nDATA) of Organic Contaminants and Biomarkers in Environmental and Food Samples Symposium: Non-Targeted Testing for Food Authenticity — Ideas, Challenges, Requirements

Agricultural Materials Community Meeting

Exhibit Hall

Poster Presentations: Botanical and Dietary Supplements, Food Nutrition and Food Allergens, Food Authenticity and Food Fraud, and Miscellaneous

8:15am – 9:45am


WEDNESDAY, SEPTEMBER 11, 2019 7:45am – 8:15am Refreshment Break 8:00am – 9:30am AOAC Method Validation: Recent Trends and Recommendations 8:00am – 12:00pm Registration 8:15am – 9:45am Symposium: Community Perspective of Food Allergen Measurement 8:15am – 9:45am Steven Moser Memorial Session: Advanced Topics in Pesticide Analytical Methods 8:15am – 9:45am

8:15am – 9:45am

Symposium: The Complexity of Validating STEC Methods to Address Varying Global Needs

9:45am – 10:15am 9:45am – 10:15am 10:00am – 5:00pm

Exhibitor Presentation: Inorganic Ventures

Refreshment Break

Poster Presentations: Detection and Measurement of Natural Toxins, Agriculture and Environment, Cannabis, General Methods, Quality Assurance and Accreditation, and Performance Tested Methods SM Sections: Best Practices and Critical Partners in Achieving the Strategy of AOAC INTERNATIONAL Symposium: New Blood 2019 — Developing Methods for the Detection of Important Chemical Analytes, Residues and Contaminants

10:15am – 11:45am

TDRM Symposium: The Importance of Public Private Partnerships in the Development of Reference Materials

10:15am – 11:45am

9:45am – 10:15am 9:45am – 10:15am 10:00am – 1:30pm

Exhibitor/Partner Presentation: ChromaDex Inc.

10:15am – 11:45am 10:15am – 11:45am

Symposium: Food Fraud Detection Goes Mobile

Refreshment Break

Symposium: How Can NGS Based Methods Advance Food Safety and Quality Programs?

AOAC Expert Review Panel for Veterinary Drug Residue Methods

11:45am – 1:15pm 12:00pm – 1:00pm 12:00pm – 1:00pm 12:00pm – 2:30pm 12:00pm – 3:00pm 12:00pm – 3:00pm 12:00pm – 2:30pm 12:30pm – 2:30pm 1:00pm – 3:00pm 1:30pm – 2:30pm 1:30pm – 3:00pm 2:00pm – 2:30pm 2:00pm – 3:00pm 2:00pm – 2:30pm

Contaminants Subgroup Meeting — Veterinary Drugs

10:00am – 5:00pm

Poster Presentations: Analysis of Foodborne Contaminants and Residues, Analysis of Non-Foodborne Contaminants and Residues, and Microbiological Methods

Poster Author Presentations

Exhibitor/Partner Presentation: Agilent Technologies

10:15am – 11:45am 10:15am – 11:45am

Symposium: Latest Developments in Gluten Analysis

Committee on Sections Meeting

Symposium: NMR Advancement in Quality Control and Compendial Applications TDRM Symposium: Reference Material Needs for Food Safety

Exhibit Hall

AOAC Research Institute Advisory Council Meeting

10:15am – 11:45am

AOAC Spotlight

11:45am – 1:00pm 12:00pm – 1:00pm 1:00pm – 2:30pm

Technical Programming Council Meeting

AOAC Working Group on Food Allergens

Poster Author Presentations

AOAC Committee on Statistics Meeting

Symposium: Validation and Implementation of Emerging Methods for Food Allergen and Gluten Measurement Symposium: Improving the Measurement of Nutritional and Botanical Compounds Strategies and Insights from NIST Quality Assurance Programs

TDLM Executive Committee Meeting

Contaminants Subgroup Meeting — Environmental and Emerging Contaminants Exhibitor Presentation: Biolan Microbiosensores S.L.

1:00pm – 2:30pm

1:00pm – 2:30pm

Symposium: Certified Reference Materials — Advancements in Manufacturing and Stability

Exhibitor/Partner Presentation: USP

Refreshment Break, Co-Sponsored by ELISA Technologies, Inc.

2:30pm – 3:00pm 3:00pm – 4:30pm

Refreshment Break

Symposium: Cannabis and Cannabis Byproducts — An Update on the State of Industry and Current Challenges

3:00pm – 4:30pm 3:00pm – 4:30pm

Symposium: Global Perspectives on Mycotoxins in Food

Symposium: New Tools for Food Fraud, an Old Problem with Perpetually New Intricacy

3:00pm – 4:30pm 3:00pm – 4:30pm

Symposium: Prebiotic, an Evolving Nutrition Concept

Symposium: Utilization of Enzymes for Analytical Analyses — Breakthroughs and Important Cautions

3:00pm – 4:30pm

Symposium: Alternative Models for Characterizing Accuracy

4:30pm – 6:00pm 8:00pm – 11:00pm


3:00pm – 7:00pm 4:30pm – 6:00pm 4:30pm – 6:00pm 4:30pm – 6:00pm 4:30pm – 7:30pm 4:45pm – 6:45pm 5:00pm – 6:00pm 5:00pm – 6:30pm 5:30pm – 6:30pm 6:00pm – 7:00pm

AOAC Expert Review Panel for Low Lactose Sugars

Annual Meeting Closing Reception

Contaminants Subgroup Meeting — Pesticides

China Section Business Meeting

Membership Committee Meeting


Mycotoxin Community Meeting

Food Allergen Community Meeting

8:00am – 11:00am 9:00am – 1:00pm 9:00am – 2:00pm

Editorial Board Meeting

TDRM Members Meeting

AOAC Official Methods Board Meeting

Europe Section Executive Committee Meeting

Training Course: AOAC Laboratory Validation

Sub-Saharan Africa Section Meeting

Reception for TDRM Members, Co-Sponsored by Mérieux NutriSciences, MilliporeSigma, and FONA International Inc.

6:15pm – 7:45pm

Contaminants Subgroup Meeting — Metals

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Keynote Address

MONDAY, SEPTEMBER 9, 2019 8 : 30am – 10 : 00am Mindy M. Brashears, Ph.D., U.S. Department of Agriculture’s (USDA) Deputy Under

Secretary for Food Safety (Invited) About Dr. Mindy M. Brashears

Dr. Mindy M. Brashears is the U.S. Department of Agriculture’s (USDA) Deputy Under Secretary for Food Safety. Dr. Brashears comes to USDA from Texas Tech University where she was a Professor of Food Safety and Public Health and the Director of the International Center for Food Industry Excellence. Dr. Brashears’ research program focused on improving food safety standards to make an impact on public health. Her work evaluated interventions in pre- and post-harvest environments and on the emergence of antimicrobial drug resistance in animal feeding systems. Dr. Brashears also led international research teams of

students and faculty to Mexico, Central and South America to improve food safety and security in these sectors and to set up sustainable agriculture systems in impoverished areas. She taught courses in food microbiology and food safety and offered industry training opportunities in Hazard Analysis and Critical Control Points (HACCP), food sanitation, recalls and food security. Dr. Brashears has been nominated to be USDA Under Secretary for Food Safety. She is a past-Chair of the National Alliance for Food Safety and Security and of the USDA multi-state research group. She is a Fellow of the National Academy of Inventors and has received numerous awards including the International Association for Food Protection Laboratorian Award, the American Meat Science Association (AMSA) Distinguished Research Award, the AMSA Distinguished Industry Service Award and was listed in the National Provisioner’s Top 25 Future Icons in the Beef Industry. She has an extensive publication record in peer-reviewed journals and has been invited to speak at national and international events on the topics of her research to give keynote addresses. Her research has resulted in more than 20 patents/patents pending for her innovative approach to improving food safety in the food supply. Under Dr. Brashears’ leadership, the Food Safety and Inspection Service will continue its mission of protecting the public’s health through the implementation of its three strategic goals : Prevent Foodborne Illness and Protect Public Health; Modernize Inspection Systems, Policies, and the Use of Scientific Approaches; and Achieve Operational Excellence.


Wiley Award Address Nature Exposed to Our Method of Questioning: Reliability of Measurements Made on Natural Products

MONDAY, SEPTEMBER 9, 2019 1 : 00 pm – 1 : 30pm Joseph M. Betz, Ph.D., Acting Director, Office of Dietary Supplements, U.S. National Institutes of Health Wiley Award winner Joseph M. Betz, acting director of the Office of Dietary Supplements (ODS) at the National Institutes of Health (NIH) in Bethesda, Maryland, USA, will deliver the Wiley Award Address and chair the Wiley Award Symposium at this fall’s AOAC Annual Meeting in Denver, Colorado, USA. In his address, “Nature Exposed to Our Method of Questioning—Reliability of Measurements Made on Natural Products,” Betz will examine the principles of assuring data integrity and provide an overview of approaches to demonstrating method performance. He will stress the importance of demonstrating integrity and reproducibility in natural products research.

Natural product research encompasses a spectrum of biomedical and chemical investigations ranging from new compound discovery to pharmacokinetic and other clinical studies. Common to such investigations is the need to demonstrate integrity and reproducibility of interventions and data collected about the interventions and clinical data. Data quality efforts include assuring that biomass is properly identified, herbarium specimens are kept and cataloged, quantitative chemical measurements are accurate and precise, and analytical methods are transferrable to other laboratories. Modern research on botanicals may include discovery of bioactive phytochemicals, including investigations of synergistic effects of complex mixtures in the botanical matrix. In the phytomedicine field, botanicals and their contained mixtures are considered the active pharmaceutical ingredient (API), and natural product scientists are increasingly called upon to supplement their molecular discovery work by assisting in the development of analytical tools for assessing complex products. Unlike single-chemical API, botanicals are variable because their composition depends on genotypic and phenotypic variation, geographical origin, weather exposure, harvesting practices, and processing. Inherent variability in raw materials and proprietary manufacturing processes can result in inconsistent research materials and commercial products that are under-potent, over-potent, and/or contaminated. Natural product chemists have routinely developed quantitative methods for phytochemicals of interest as part their overall investigations. Publication of such methods occurs at the discretion of individual investigators, but when published, the methods described often serve as starting points for methods used by researchers and regulatory and quality control scientists. Ideally, published methods should be accurate, precise, and reproducible. Accordingly, the Wiley Award Address will focus on data quality efforts to ensure integrity of results and approaches to demonstrating method performance.

The Harvey W. Wiley Award is AOAC INTERNATIONAL’s top scientific honor, given annually for career accomplishments in the analytical sciences.

Continued on page 10

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Wiley Award Address (Continued)

ABOUT JOSEPH M. BETZ Joseph M. Betz is the acting director of the U.S. National Institutes of Health-Office of Dietary Supplements (NIH-ODS). He holds a bachelor’s degree in biology from the Philadelphia College of Pharmacy and Science (PCP&S), an M.Sc. in marine and environmental science from C.W. Post/Long Island University, and a Ph.D. in pharmacognosy from PCP&S. Betz spent 12 years as a research chemist at the U.S. Food and Drug Administration’s (FDA) Center for Food Safety and Applied Nutrition. Following his work at FDA, he moved on to become vice president for scientific and technical affairs at the American Herbal Products Association (AHPA). He joined NIH-ODS as the director of the newly created Analytical Methods and Reference Materials Program in 2002. In that capacity, he oversaw several large intra- and extra-governmental initiatives with the goal of providing stakeholders with rugged, validated analytical methods for measuring constituents of natural products in research, industrial, and regulatory settings. Betz is a 30-year member of AOAC INTERNATIONAL and a Fellow of AOAC. He was instrumental in the NIH/ODS-AOAC dietary supplements project, one of the largest, most challenging, and successful projects in AOAC’s history. Since 2001, the project has yielded more than 30 standards and as many validated methods for priority dietary supplement ingredients that reflect the needs of the dietary supplement community. He has been a member of the AOAC Editorial Board since 2009 and assumed the role of chairman in 2017. Betz is author or co-author of over 100 peer-reviewed publications and book chapters. He has received a number of awards, including the AOAC Technical Division on Reference Materials (TDRM) Reference Material Achievement Award, the American Botanical Council’s Norman R. Farnsworth Award for excellence in botanical research, AHPA’s Herbal Insight Award for contributions to the botanical sciences, and the American Society of Pharmacognosy’s Varro E. Tyler Prize for outstanding scientific contributions to the field of dietary supplements. He was recently recognized by the NIH Office of the Director with an Honor Award for his contributions to the establishment and development of the ODS Vitamin D Standardization Program.


Education and Stakeholder PROGRAMS

FRIDAY, SEPTEMBER 6–SUNDAY, SEPTEMBER 8 Join AOAC for 3 days of Education and Stakeholder Programs. These sessions do NOT have an additional fee. However, you must register for the Annual Meeting to attend these sessions.

FOOD AUTHENT ICI T Y/FRAUD PROGRAM Friday, September 6, 9:00 am – 5:00 pm

This newly launched AOAC program supports the analytical needs of our stakeholders to address intentional and economically motivated food adulteration. In this meeting, the Non-Targeted Testing Working Group will be reviewing a draft standard, the first of its kind to identify and put parameters around acceptance criteria for non-targeted testing. This standard will apply to three commodities: milk, olive oil, and honey. In addition, the Targeted Testing Working Group will also share the results of gap analysis of existing methodologies.

INFANT FORMULA AND ADULT NUTR I T IONAL S Saturday, September 7, 8:30 am – 5:00 pm

The AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN) may be forming new working groups at the Annual Meeting and will deliver updates on harmonized methods in progress with ISO and IDF as well as progress on methods in the Codex process. The AOAC ERP for SPIFAN Nutrient Methods will also meet to review methods for either First Action Official Methods SM status or to make a recommendation regarding Final Action Official Methods SM to the AOAC Official Methods Board.

CANNAB I S ANALY T ICAL SCI ENCE PROGRAM (CASP ) MEET ING Saturday, September 7, 9:00 am – 5:00 pm

Currently, no globally recognized standards and methods exist for validating the safety, potency, and label claims of cannabis products available to consumers. To respond to this growing need, AOAC launched the CASP program. Three working groups are developing standards for analytical methodology for measuring cannabinoid levels in cannabis and hemp consumables, measuring chemical contaminants, and detecting microbial contaminants in cannabis. At the Annual Meeting, the working groups will present draft standards on residual solvents, identifying Aspergillus spp. in cannabis, and cannabinoid quantitation in hemp plant materials for adoption as SMPRs. In addition, attendees will discuss next steps and identify priority subjects to tackle in the coming year.

THE ANALY T ICAL SOLUT IONS FORUM Sunday, September 8, 8:30 am – 2:30 pm

The Analytical Solutions Forum (ASF) convenes global stakeholders from government, industry and academia to identify emerging analytical needs and propose strategies to address these challenges. The theme for the ASF at this year’s Annual Meeting is “Analytical Tools for Emerging Agricultural Products.” The morning plenary session will highlight two focus areas: Botanicals and Herbal Supplements and Biostimulants and Soil Amendments . Concurrent breakout sessions will then follow to separately consider these subtopics in greater depth. Through the active participation of attendees, the goal will be to identify areas of analytical need and provide a framework for potential program development. The outputs from each breakout session will then be presented and discussed during the afternoon plenary session. During the ASF, attendees can attend an optional “Lunch and Learn” session to learn the key elements of the ASF and how it will serve to drive new program development.

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TO REGISTER FOR ALL COURSES AOAC/A2LA ISO/I EC 17025:2017 BRIDGING THE GAP FROM 2005 (MS 110) Saturday, September 7, 9:00 am – 5:00 pm

Fee: $650.00, includes print copy of ALACC Guidelines This course is a one-day overview of the changes made to ISO/IEC 17025 in its latest revision. The participants will learn the significant and subtle changes to existing ISO/IEC 17025 laboratory systems, as well as the necessary steps to ensure conformity to the new Standard. The course materials will be presented in an interactive lecture style (70%), and application exercises (30%). Attendees are provided a watermarked copy of 17025:2017 for training use only — not considered legal copy for ownership purposes. COURSE CONTENT • Course Introduction • New and revised Quality Management Requirements • New and revised Technical Requirements • Identifying adjustments to your existing ISO/IEC 17025:2005 Quality Documentation PREREQUI S I TES Attendees should have at least three to four years’ experience with ISO/IEC 17025:2005. This course is intended for laboratory management and quality personnel whose organizations currently hold an accreditation to ISO/ IEC 17025:2005. L EARNING OUTCOMES After successful completion of the course, the participant will be able to: • Describe the process-based approach of the Standard. • Explain new concepts in 17025:2017 such as: • Continual Improvement (using PDCA and KPIs); • Verification and Validation; • Decision Rules; • Principles of Impartiality; and • Risk Based Thinking

• Analyze scenarios to identify non-conformities, risks, and opportunities related to the new requirements in the standard • List the areas where Documents and Records are required under the new Standard.

COURSE INSTRUCTOR Roger M. Brauninger, American Association for Laboratory Accreditation (A2LA) Roger Brauninger has worked at the American Association for Laboratory Accreditation (A2LA) since 1999. Mr. Brauninger has

conducted numerous management system assessments to ISO/IEC 17025 and 17020 and also evaluates other assessors in this role. Roger also is an APLAC and IAAC peer evaluator and has performed multiple international peer evaluations of mutual recognition partners to the ISO/ IEC 17011 standard for accreditation bodies. In his role as Biosafety Program manager, his focus is on developing and maintaining accreditation programs in the Life Sciences with emphasis on microbial and chemical risks to people, animals and the environment. He is A2LA’s point person for interacting with organizations working with food and drug safety, human and animal anti-doping, biological and chemical threat agents and since 2014 for issues related to cannabis testing. CEUs AWARDED: 0 . 7* *American Association for Laboratory Accreditation (A2LA) is accredited by the International Association for Continuing Education and Training (IACET) and is authorized to issue the IACET CEU.




Fee: $1,195.00 (2-day course) COURSE OVERV I EW

•Why “outliers” should not always be discarded • How to measure subsampling error • How to perform proper subsampling quality control • How to increase confidence in analytical results through error reduction • Data evaluation and decision-making issues resulting from poor subsampling

The means by which chemists and microbiologists apportion laboratory samples prior to testing can drastically affect the reliability of the results. For example, some may open a sample container and just scoop or pour a small portion of material off the top whereas others may try to obtain material from different parts of the sample for laboratory analysis. Others still may stir the sample first or employ some type of coning and quartering. Such practices may not adequately represent the material and thus introduce both random and systematic errors into the measurement process. In this course, participants will learn how to properly take a representative subsample for laboratory analysis. In addition, the crucial connection between primary sampling and laboratory subsampling will be investigated to bring efficiency and defensibility to the entire sampling and analytical process. This course incorporates concepts from the documents Guidance on Obtaining Defensible Samples and Guidance on Obtaining Defensible Test Portions. The attendees will have an opportunity to ask technical questions about the material presented and specific questions about subsampling situations they have encountered. L EARNING OB J ECT I VES • Sample Quality Criteria and its importance in subsampling • The Decision Unit and why it is critical for subsampling •Where subsampling errors originate and how to mitigate them •Why certain subsampling tools may bias samples • How to choose and correctly use subsampling tools and equipment • How to design cost effective subsampling protocols to achieve project goals •Why replicate samples yield different analytical results • How to properly split a sample

COURSE INSTRUCTOR Chuck, Ramsey, Envirostat, Inc. Chuck Ramsey is founder and president of EnviroStat, Inc., which specializes in development of and training on new and novel scientifically based methodologies to make defensible decisions.

These methodologies integrate project goals, quality control, sampling theory, and data interpretation into a single comprehensive decision-making approach. Ramsey specializes in development of sampling and laboratory subsambling protocols to meet specific project objectives for a variety of applications including food, feed, fertilizer, pharmaceutical, and environmental. He is the technical consultant to AAFCO and an EPA-recognized expert in the areas of sampling and data interpretation. Ramsey has received several specialized trainings and certifications; published numerous reports and peer-reviewed journal articles related to research on sampling for monitoring, source identifications, data analysis, and compliance determination; and has given numerous presentations at conferences, symposiums, and workshops on national and international topics, including technical, regulatory, and policy issues. REQUI REMENTS Read both GOOD Samples and GOOD Test Portions prior to the course. Available free at: https://www.aafco.org/ Publications

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AOAC LABORATORY VAL IDAT ION COURSE Thursday, September 12, 9:00 am – 2:00 pm Fee: $500.00

This is a review of the technical validation requirements and processes of the Performance Tested Methods SM and Official Methods of Analysis programs. The course will include breakout sessions covering the technical requirements for microbiology methods and for chemistry methods. COURSE CONTENTS Overview of the Performance Tested Methods SM and Official Methods of Analysis programs • Technical requirements and instructions for inclusivity/exclusivity (microbiology), calibration/selectivity (chemistry), matrix studies, robustness, and product consistency and stability for test kit evaluations • Harmonization with AFNOR, MicroVal, NMKL, and between PTM and OMA • Modules for: • Method developers • Independent laboratories • Expert reviewers • Target Attendees • Method developers • Independent laboratories • Candidates for AOAC Expert Reviewers L EARNING OUTCOMES Method developers: • Better understanding of AOAC processes • Improved study designs meeting AOAC and AOACRI requirements • More concise data collection • Quicker reviews and therefore faster PTM and OMA approvals Independent laboratories: • Improved chances for selection as independent laboratories • Better understanding of technical requirements and processes for performing studies • More concise data collection Candidates for AOAC Expert Reviewers: • Better understanding of AOAC processes • Improved chances for selection as an Expert Reviewer CANCE L LAT ION POL ICY If you must cancel, submit your request by email to AOAC INTERNATIONAL Customer Service or via fax to +1 (301) 924-7087, no later than September 3, 2019. No refunds will be issued for cancellations received after this date. AOAC reserves the right to cancel a course prior to the start date or delay the start date due to low enrollment, instructor availability or other uncontrollable circumstances.


THE AOAC EXPOSITION Designed to be an integral part of your Annual Meeting experience, the AOAC Exposition has a superb range of new services and technologies to examine. Over 60 leading suppliers to the analytical communities will be onsite. The Exposition offers an outstanding opportunity to learn about resources available to enhance both your individual and company performance.

EXHIBI T HALL HOURS Exhibit Hall Grand Opening & President’s Welcome Reception Sunday, September 8, 2019 7:00 pm – 9:00 pm Monday, September 9, 2019 10:00 am – 1:00 pm Tuesday, September 10, 2019 12:00 pm – 3:00 pm


AOAC has listened to your requests for additional time to visit the Exhibit Hall. AOAC will not hold scientific sessions while the Exhibit Hall is open. A light lunch will be served in the Exhibit Hall on Monday and Tuesday. Please use this time to visit the wonderful collection of vendors in the Hall.

EXHIBI TORS Following is a list of exhibitors confirmed as of press time. Please visit the AOAC web site at www.aoac.org to see additional exhibitors as they are added. If your organization is interested in exhibiting and/or sponsoring an event at the meeting, please contact Lauren Chelf at lchelf@aoac.org or 240-912-1449. A Chemtek Inc. A2LA Affinisep Agilent Technologies Alkemist Labs ANKOM Technology

COPAN Diagnostics ELISA Technologies, Inc. Erlab Inc. GERSTEL, Inc. Inorganic Ventures Interscience Laboratories Inc. IsoSciences J2 Scientific LLC LECO Corporation LGC/API Megazyme Metrohm MilliporeSigma Nacalai Tesque, Inc. National Institute of Standards and Technology Omni International

Phenomenex Pickering Laboratories, Inc. Proton OnSite Randox Food Diagnostics Restek Corporation Rocky Mountain Diagnostics, Inc. SCIEX SEAL Analytical, Inc. Shimadzu Scientific Instruments, Inc. Skalar Inc SPEX SamplePrep Thermo Fisher Scientific UCT USDA, FSIS, Accreditated Laboratory Program USP Waters Corporation

AOAC INTERNATIONAL Autoscribe Informatics Inc BioFront Technologies Biolan Microbiosensores S.L. bioMérieux, Inc. Biotage BIPEA Bruker Corporation CALA CEM Corporation ChromaDex Inc.

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AOAC Annual Meeting exhibitors and partners will hold Presentations throughout the Meeting. This venue allows more in-depth interaction and one- on-one contact between attendees and exhibiting companies. Companies will be showcasing new products, new technologies, and offering product demonstrations—you won’t want to miss this opportunity. Stop by an Exhibitor/Partner Presentation and learn more about the following companies’ products and services. MONDAY, SEPTEMBER 9, 2019 7:30 am – Pickering Laboratories 10:15 am – Eurofins 11:00 am – Thermo Fisher Scientific 11:15 am – Shimadzu Scientific Instruments, Inc. 12:15 pm – Megazyme 3:00 pm – bioMérieux, Inc. 5:00 pm – Phenomenex TUESDAY, SEPTEMBER 10 , 2019 7:00 am – Waters Corporation 9:45 am – Inorganic Ventures 12:00 pm – Agilent Technologies 1:00 pm – MilliporeSigma 2:00 pm – Biolan Microbiosensores S.L. 2:00 pm – USP Exhibitor/Partner PRESENTATIONS

WEDNESDAY, SEPTEMBER 11, 2019 9:45 am – ChromaDex Inc.


Scientific SESSIONS SUNDAY, SEPTEMBER 8, 2019 1:00 pm – 2:30 pm TDRM Training Course: Selection and Use of Reference Materials This TDRM training course will offer a lot of useful information on how to select and use appropriate reference materials as they are key tools in analytical laboratories. How can the user make an educated guess which material is fit for purpose in their laboratory and what do the different concepts stated on the certificates mean in practice? Are some materials of a higher order or not? More specifically, the training course will provide information on material selection; handling and use, under- standing of property values and their uncertainties together with explanations on metrological traceability of measurement results. Buyers and users of reference materials receive a material data sheet or a certificate that accompanies the material. The documentation and the materials are inseparable and comple- mentary. The RM-users should pay close attention to what is stated in the documentation related to the materials regardless if the material is certified or non-certified. In fact, the differences on the documents are dictated by the material category i.e. whether the material is a certified reference material or a reference mate- rial without certified properties. What do these differences mean in practice? The training will be divided in four blocks to cover the process of selecting an appropriate reference material, proper handling of the material and measurement of the target parameters, estimat- ing the measurement uncertainty including a comparison with the certified value based on a simple calculation. Co-Chair : Håkan Emteborg, European Commission – Joint Research Centre Co-Chair : Charles Barber, U.S. National Institute of Standards and Technology Håkan Emteborg, European Commission, Joint Research Centre Charles Barber, U.S. National Institute of Standards and Technology 3:00 pm – 4:30 pm TDLM/TDRMWorkshop: What Auditors are Seeing as Top Findings for Laboratories Being Accredited to the ISO/IEC 17025:2017 Standard The 2017 version of the ISO/IEC 17025 standard has been in use for approximately one year and trends are beginning to present themselves as more and more assessments occur around the world. In this workshop, we will hear from accrediting bodies from the US and Canada, as well as an assessor and a labora- tory for their perspective.

Co-Chair : Brad Stawick, SGS North America, Inc. Co-Chair : John Szpylka, Mérieux NutriSciences Corporation Trace McInturff, A2LA - American Association for Laboratory Accreditation Colleen Cotter, CALA Brad Stawick, SGS North America, Inc. MONDAY, SEPTEMBER 9, 2019 1:00 pm – 1:30 pm Harvey W. Wiley Award Address: Nature Exposed to our Method of Questioning — Reliability of Measurements Made on Natural Products Joseph M. Betz, Ph.D., Office of Dietary Supplements, U.S. National Institutes of Health 1:30 pm – 3:00 pm Wiley Award Symposium: Advances in Analytical Methods for Botanical Dietary Supplements and for Clinical Nutritional Assessment The Harvey W. Wiley Award focuses on outstanding contri- butions to the development of analytical methods in areas of interest to AOAC INTERNATIONAL. The session in honor of the 2019 Wiley Awardee will focus on advances in analytical methods for the chemical characterization of botanical dietary supplements and for clinical nutritional assessment. Most dietary supplements contain natural product ingredients and are therefore complex mixtures of chemical constituents that require advanced chemical separations and detection, predominantly using liquid chromatography (LC) with mass spectrometry (MS) or tandem MS (MS/MS) detection, for chemical characteriza- tion. These advanced chemical analysis approaches are applied for qualitative and quantitative characterization of botanical products to support metabolomic studies, plant identification and authentication, efficacy studies, and safety and quality assess- ments. The importance of appropriate method selection and validation for the characterization of botanical products will be addressed. Regarding clinical nutritional assessment, the session will high- light an international effort to assist in the standardization of measurements for the determination of a clinically significant nutritional marker for vitamin D status, i.e., 25-hydroxyvitamin D. The approach to standardization included the develop- ment of higher-order reference methods based on LC-MS/ MS, the development of standard reference materials (SRMs) to provide quality assurance of 25(OH)D measurements, and interlaboratory assessments of the performance of routinely used immunoassay-based tests versus LC-MS/MS methods. Chair : Stephen A. Wise, National Institutes of Health

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Richard van Breemen, Linus Pauling Institute High-Throughput Affinity Selection-Mass Spectrometry Identification of Pharmacologically Active Natural Products in Complex Mixtures Paula Brown, British Columbia Institute of Technology The Importance of Methods Selection and Validation for Ensuring the Safety & Quality of Botanical Dietary Supplements. Stephen Wise, National Institutes of Health Assessing Vitamin D Status – Analytical Challenges and Accomplishments Recent Trends in Elemental Analysis Applications The session “Recent Trends in Elemental Analysis Applications” will focus on the application of advanced elemental analysis methods and concepts to determine elemental contaminants in various commodities which have recently received increased interest including cannabis, pet foods, and food supplements. These applications represent signification impacts to food safety and regulatory monitoring. Each speaker will discuss a different topical issue in the area of advanced elemental analysis and elemental analysis utilizing a unique technique applied to the various matrices. Co-Chair : Jenny Nelson, Agilent Technologies, Inc. Co-Chair : Kevin Kubachka, U.S. Food and Drug Administration Katarzyna Banaszewski, NOW Foods Arsenic Speciation in Krill Oil by Liquid Chromatography Inductively Coupled Plasma Mass Spectrometry Lawrence Pacquette, Abbott Laboratories Arsenic, Iodine, and Bromine Speciation Analysis in Infant Formula, and Nutritional Products using HPLC-ICP-MS Robert Wilson, U.S. Food and Drug Administration Analysis of Thyroid Hormones in Dog Food by LC-ICP-MS Ini Afia, CannaSafe Elemental Analysis of Cannabis and Cannabis Products ROUNDTABLE: Method Fitness in a time of FSMA— How Should Laboratories and Food Manufacturers Decide on Method Suitability? The Food Safety Modernization Act (FSMA) requires food companies to verify that their preventive controls are effective. To do this they test product and environmental samples. FSMA additionally requires that methods be scientifically suitable, or “fit for purpose”, and this responsibility also lands on the food company. There is very little guidance for manufacturers or commercial laboratories that defines “fitness for purpose” in practical terms. This is different from the situation for regulatory laboratories and diagnostic test kit makers who have detailed validation schemes and guidance documents available. The panelists at this roundtable will describe the current state of affairs, and the discussion will permit clarification and allow ideas to be shared that might lead to improved approaches. Co-Chair : David Legan, Eurofins Co-Chair : Larry Cohen, Treehouse Foods, Inc. Christie Hancock, Conagra Brands

Patrick Bird, PMB Biotek Consulting Felix Haesler, Eurofins GeneScan Technologies GmbH DeAnn Benesh, 3M Food Safety W. Evan Chaney, Diamond V/Cargill Animal Nutrition 3:30 pm – 5:00 pm Application of DNA Technologies and Standards in the Authentication of Botanicals for Quality Control of Botanical Dietary Supplements DNA-based methods are quickly recognized as valuable contri- butions to botanical authentication to complement the traditional morphological and chemical authentication methods because of the fidelity and specificity of DNA sequences in plant species. One challenge for DNA-based botanical identification is the dynamic changes of DNA quantity and quality throughout manufacturing processes. Depending on the characteristics of DNA molecules, different DNA methods are required to trace and qualify botanical materials at different processing stages. However, rigorous validated and reviewed DNA-based botani- cal methods are limited and their application scopes are usually not well-defined. AOAC and USP have a long history of adopt- ing DNA-based molecular methods as AOAC Official Methods and USP monographs and general chapters. However, most of them are focused on the identification of biological materials from animal sources, probiotics and the detection of foodborne pathogens. Adding reliable and robust DNA-based botani- cal methods into AOAC Official Methods and USP standards will not only help the botanical dietary supplement industry to accurately identify botanicals at species level, but also complete AOAC’s and USP’s portfolio of DNA-based methods on biologi- cal material identification. This session, co-sponsored by Herbalife Nutrition and USP, aims to emphasize the value of DNA-based methods in botanical authentication, increase the transparency of available methods, and facilitate the acceptance of these methods by the analytical communities. Detailed topics include: 1) reference standards for DNA-based botanical identification, 2) bioinformatics tools for botanical DNA analysis, 3) DNA-based supply chain verifica- tion, and 4) industry experiences on authentication of botanical materials at different processing stages. Co-Chair : Yanjun Zhang, Herbalife International of America Inc. Co-Chair : Nandakumara Sarma, U.S. Pharmacopeia (USP) Co-Chair : Silva Babajanian, Herbalife International of America Inc. Steven Newmaster, University of Guelph DNA-Based Supply Chain Verification Ning Zhang, U.S. Pharmacopeia (USP) Reference Standards for DNA-Based Botanical Identification Damon Little, The New York Botanical Garden Bioinformatics Tools for Botanical DNA Analysis Zhangfei Lu, Herbalife International of America Inc. Industry Experiences on Authentication of Botanical Materials at Different Processing Stages

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