2019 AOAC Annual Meeting - Preliminary Program

Richard van Breemen, Linus Pauling Institute High-Throughput Affinity Selection-Mass Spectrometry Identification of Pharmacologically Active Natural Products in Complex Mixtures Paula Brown, British Columbia Institute of Technology The Importance of Methods Selection and Validation for Ensuring the Safety & Quality of Botanical Dietary Supplements. Stephen Wise, National Institutes of Health Assessing Vitamin D Status – Analytical Challenges and Accomplishments Recent Trends in Elemental Analysis Applications The session “Recent Trends in Elemental Analysis Applications” will focus on the application of advanced elemental analysis methods and concepts to determine elemental contaminants in various commodities which have recently received increased interest including cannabis, pet foods, and food supplements. These applications represent signification impacts to food safety and regulatory monitoring. Each speaker will discuss a different topical issue in the area of advanced elemental analysis and elemental analysis utilizing a unique technique applied to the various matrices. Co-Chair : Jenny Nelson, Agilent Technologies, Inc. Co-Chair : Kevin Kubachka, U.S. Food and Drug Administration Katarzyna Banaszewski, NOW Foods Arsenic Speciation in Krill Oil by Liquid Chromatography Inductively Coupled Plasma Mass Spectrometry Lawrence Pacquette, Abbott Laboratories Arsenic, Iodine, and Bromine Speciation Analysis in Infant Formula, and Nutritional Products using HPLC-ICP-MS Robert Wilson, U.S. Food and Drug Administration Analysis of Thyroid Hormones in Dog Food by LC-ICP-MS Ini Afia, CannaSafe Elemental Analysis of Cannabis and Cannabis Products ROUNDTABLE: Method Fitness in a time of FSMA— How Should Laboratories and Food Manufacturers Decide on Method Suitability? The Food Safety Modernization Act (FSMA) requires food companies to verify that their preventive controls are effective. To do this they test product and environmental samples. FSMA additionally requires that methods be scientifically suitable, or “fit for purpose”, and this responsibility also lands on the food company. There is very little guidance for manufacturers or commercial laboratories that defines “fitness for purpose” in practical terms. This is different from the situation for regulatory laboratories and diagnostic test kit makers who have detailed validation schemes and guidance documents available. The panelists at this roundtable will describe the current state of affairs, and the discussion will permit clarification and allow ideas to be shared that might lead to improved approaches. Co-Chair : David Legan, Eurofins Co-Chair : Larry Cohen, Treehouse Foods, Inc. Christie Hancock, Conagra Brands

Patrick Bird, PMB Biotek Consulting Felix Haesler, Eurofins GeneScan Technologies GmbH DeAnn Benesh, 3M Food Safety W. Evan Chaney, Diamond V/Cargill Animal Nutrition 3:30 pm – 5:00 pm Application of DNA Technologies and Standards in the Authentication of Botanicals for Quality Control of Botanical Dietary Supplements DNA-based methods are quickly recognized as valuable contri- butions to botanical authentication to complement the traditional morphological and chemical authentication methods because of the fidelity and specificity of DNA sequences in plant species. One challenge for DNA-based botanical identification is the dynamic changes of DNA quantity and quality throughout manufacturing processes. Depending on the characteristics of DNA molecules, different DNA methods are required to trace and qualify botanical materials at different processing stages. However, rigorous validated and reviewed DNA-based botani- cal methods are limited and their application scopes are usually not well-defined. AOAC and USP have a long history of adopt- ing DNA-based molecular methods as AOAC Official Methods and USP monographs and general chapters. However, most of them are focused on the identification of biological materials from animal sources, probiotics and the detection of foodborne pathogens. Adding reliable and robust DNA-based botani- cal methods into AOAC Official Methods and USP standards will not only help the botanical dietary supplement industry to accurately identify botanicals at species level, but also complete AOAC’s and USP’s portfolio of DNA-based methods on biologi- cal material identification. This session, co-sponsored by Herbalife Nutrition and USP, aims to emphasize the value of DNA-based methods in botanical authentication, increase the transparency of available methods, and facilitate the acceptance of these methods by the analytical communities. Detailed topics include: 1) reference standards for DNA-based botanical identification, 2) bioinformatics tools for botanical DNA analysis, 3) DNA-based supply chain verifica- tion, and 4) industry experiences on authentication of botanical materials at different processing stages. Co-Chair : Yanjun Zhang, Herbalife International of America Inc. Co-Chair : Nandakumara Sarma, U.S. Pharmacopeia (USP) Co-Chair : Silva Babajanian, Herbalife International of America Inc. Steven Newmaster, University of Guelph DNA-Based Supply Chain Verification Ning Zhang, U.S. Pharmacopeia (USP) Reference Standards for DNA-Based Botanical Identification Damon Little, The New York Botanical Garden Bioinformatics Tools for Botanical DNA Analysis Zhangfei Lu, Herbalife International of America Inc. Industry Experiences on Authentication of Botanical Materials at Different Processing Stages

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18 SEPTEMBER 6–12, 2019 SHERATON DENVER DOWNTOWN HOTEL