2019 Vet Drug Residues ERP - Review Book

3. Is there information demonstrating that the method system suitability tests and controls as specified in the SMPR worked appropriately and as expected? If no, please specify. 4. Based on the supporting information, is the method written clearly and concisely? If no, please specify the needed revisions. 5. Based on the supporting information, what are the pros/strengths of the method? 6. Based on the supporting information, what are the cons/weaknesses of the method?

Yes, however recommend to establish matrix wise cut off value.

Yes, Need to be improved in the following points. 1) Standard preparation details 2) MRM conditions of both Quantifier and qualifier 3) Detection capabilities (CC-beta) calculations

1) Covered all the matrices with appropriate reference standards 2) Sufficient number of samples analyzed as per SMPR.

1) Selectivity need to be performed even though using LC-MS/MS 2) Detection capabilities (CC-Beta) need to be established even for screening method (Refer EC 657/2002). 3)Details of standard preparation and MRM conditions need to be given.

7. Any general comments about the method?

Well-developed method and covered all the matrices and no of samples as per SMPR however need to address above mentioned points.

V. Final Recommendation Do you recommend this method be adopted as a First Action and published in the Official Methods of Analysis of AOAC INTERNATIONAL? Please specify rationale.

Yes, the method is recommended for First action after addressing above mentioned points appropriately