6. AOACSPIFANMethods-2018Awards

258

Reddy: J ournal of AOAC I nternational V ol. 98, N o . 4, 2015  1139

03121513 Smooth(Mn,2x2) QC2

MRMof2 channels,ES- 212 > 182

03121519 Smooth(Mn,2x2) QC4

MRMof2 channels,ES- 212 > 182

MFA-2NPH 4.05

MFA-2NPH 4.05

9.197e+004

1.622e+006

100

100

%

%

4.73

6.59

6.65

4.81

6.27

3.16 2.83 3.35

5.48 5.88

0

min

0

min

03121513 Smooth(Mn,2x2) QC2

MRMof2 channels,ES- 216 > 186

03121519 Smooth(Mn,2x2) QC4

MRMof2 channels,ES- 216 > 186

MFA-2NPH_IS 4.04

MFA-2NPH_IS 4.04

3.434e+005

2.967e+005

100

100

%

%

0

min 0.50 1.00 1.50 2.00 2.50 3.00 3.50 4.00 4.50 5.00 5.50 6.00 6.50 7.00

0

min 0.50 1.00 1.50 2.00 2.50 3.00 3.50 4.00 4.50 5.00 5.50 6.00 6.50 7.00

Figure 2015.04E. QC overspike High at 500 ng/g powder. II. EXAMPLE CALIBRATION CURVE SEE FIGURE XX Compound name:MFA-2NPH Correlation coefficient: r = 0.999397, r^2 = 0.998795 Calibration curve:0.953568 * x+ 0.0208565

Figure 2015.04C. QC overspike Low at 25 ng/g powder.

03121516 Smooth(Mn,2x2) QC3

MRMof2 channels,ES- 212 > 182

MFA-2NPH 4.05

Response type: Internal Std ( Ref2 ),Area * ( IS Conc. / IS Area ) Curve type:Linear,Origin:Exclude,Weighting:1/x,Axis trans:None

3.995e+005

100

%

5.0

Residual -5.0 0.0

4.81

6.58 6.27

0

min

Conc

03121516 Smooth(Mn,2x2) QC3

MRMof2 channels,ES- 216 > 186

MFA-2NPH_IS 4.04

3.304e+005

100

%

50.0

Response -0.0

0

min 0.50 1.00 1.50 2.00 2.50 3.00 3.50 4.00 4.50 5.00 5.50 6.00 6.50 7.00

Conc

-0

10

20

30

40

50

60

70

80

90 100

Figure 2015.04F. Calibration curve and residual plot.

Figure 2015.04D. QC overspike Med at 100 ng/g powder.

K. Example Calibration Curve See Figure 2015.04F . References

(1)  J. Chromatogr. A 881 , 365(2000) (2)  J. Chromatogr. A 1139 , 271(2007) (3) AOAC SMPR 2015.001 J. AOAC Int. (future issue)