AOAC 133rd Annual Meeting - Final Program

Scientific Sessions | Wednesday

2:00 PM Leveraging Quality Assurance Programs to Assess Current Analytical Community ‘State-of-the-Science’ Holly E. Johnson, American Herbal Products Association The NIST Quality Assurance Program (QAP) provides a unique opportunity to assess laboratory capabilities across the indus- try by making extremely well-characterized, blinded materials available to be evaluated by a variety of methods. The QAP can offer insights on the abilities of test methods and analytical platforms to return accurate, precise, and specific results. With the wide array of complex and processed botanical materials in commerce, choosing test methods which are appropriate for their intended use is critical for authentication and regulatory compliance. And whether evaluation of botanical materials is performed in-house or at a contract testing laboratory, the QAP results can provide data to support a laboratory’s perfor- mance in executing a particular analysis and build confidence in risk assessments or when qualifying a testing laboratory. The American Herbal Products Association collaborated with NIST on a recent QAP that included a botanical identity exercise to assess determination of identity in Ginkgo and related botanical materials, including adulterants. This talk will review data from the collaborative Ginkgo identity testing exercise and discuss the results and the insights revealed about identity testing, orthogo- nal evaluations, and selecting fit-for-purpose methods. SYMPOSIUM: Certified Reference Materials— Advancements in Manufacturing and Stability 1:00 PM – 2:30 PM Plaza F Chair: Don Shelly, LGC Standards 1:00 PM Improvements in Stability of Large Custom Certified Reference Material Mixtures Daniel Biggerstaff, HuiChen Stavros, LGC Standards Innovations in determining the long-term stability of custom products (including large mixtures) using rapid isochronous studies and the comparison of various models to classical data have evolved to meet the needs of industry for certified reference materials. The greatest issues to overcome have resulted from the move of the food safety industry towards multiple residue screening methods for 500+ pesticides per analysis, and the use of internal marker compounds to identify analyte degradation in working calibration solutions and quality control solutions. However, there are still challenges in CRM characterization to overcome, including the challenges of providing the isomer ratios of pesticide impurities in the cannabis testing industry, etc. Aspects of characterization and uncertainty will be discussed.

within the community. Participants receive reports and individual certificates after each exercise. HAMQAP offers a unique tool encouraging sound measurement practices for the assessment of the quality of measurements and provides feedback about performance that can assist participants in improving laboratory operations. 1:30 PM Leveraging Quality Assurance Programs for Multi-Laboratory Method Validation Studies Elizabeth M. Mudge, National Research Council Canada, Melissa M. Phillips, Catherine A. Rimmer, U.S. National Institute of Standards and Technology, Paula N. Brown, British Columbia Institute of Technology As the food and supplement industry has evolved to the use of more highly processed materials, analytical methods must move away from non-specific methods unable to detect adul- teration. Turmeric ( Curcuma longa L.) roots have a characteristic yellow color attributed to curcuminoids and as such extracts are at-risk for adulteration by synthetic colorants. To advance the analytical methods for establishing quality of turmeric roots and root-based supplement products, AOAC INTERNATIONAL established a SPDS working group in 2015. SMPR ® 2016.003 for the quantitation of individual curcuminoids in turmeric raw materials, ingredients and finished dietary supplements was published and the resultant OMA 2016.16 received First Action approval. In order to establish the method as suitable for Final Action status, method reproducibility data is required. In a joint project between the method authors and the NIST/NIH Dietary Supplement Laboratory Quality Assurance Program, partici- pating laboratories were provided the option to follow OMA 2016.16, supporting the incremental collection of reproducibility data over time. Nine laboratories participated and evaluated 10 different turmeric products ranging from dry, powdered roots to multi-component dietary supplements, employing OMA 2016.16. This talk highlights approaches taken to leverage a QA program for collecting reproducibility data and the results of this non-traditional multi-laboratory study.

28 SEPTEMBER 6–12, 2019 SHERATON DENVER DOWNTOWN HOTEL