AOAC 133rd Annual Meeting - Final Program

Scientific SESSIONS

SUNDAY, SEPTEMBER 8, 2019 TDRM Training Course: Selection and Use of Reference Materials 1:00 PM – 2:30 PM Governor’s Square 14 Chairs: Håkan Emteborg, European Commission – Joint Research Centre Charles Barber, U.S. National Institute of Standards and Technology Håkan Emteborg, European Commission – Joint Research Centre Charles Barber, U.S. National Institute of Standards and Technology This training course will offer useful information on how to select and use appropriate reference materials as they are key tools in analytical laboratories. How can the user make an educated guess which material is fit-for-purpose in their laboratory and what do the different concepts stated on the certificates mean in practice? Are some materials of a higher order or not? More specifically, the training course will provide information on material selection; handling and use, understanding of prop- erty values and their uncertainties together with explanations on metrological traceability of measurement results. Buyers and users of reference materials receive a material data sheet or a certificate that accompanies the material. The documentation and the materials are inseparable and complementary. The RM-users should pay close attention to what is stated in the documentation related to the materials regardless if the mate- rial is certified or non-certified. In fact, the differences on the documents are dictated by the material category i.e. whether the material is a certified reference material or a reference material without certified properties. What do these differences mean in practice? The training will be divided in four blocks to cover the process of selecting an appropriate reference material, proper handling of the material and measurement of the target parameters, estimating the measurement uncertainty includ- ing a comparison with the certified value based on a simple calculation. TDLM/TDRMWorkshop: What Auditors are Seeing as Top Findings for Laboratories Being Accredited to the ISO/IEC 17025:2017 Standard

The 2017 version of the ISO/IEC 17025 standard has been in use for approximately one year and trends are beginning to present themselves as more and more assessments occur around the world. In short, we will discuss areas that changed as a result of new requirements and areas that remain the same from the last version of the standard. In this workshop, we will hear from accrediting bodies from the U.S. and Canada, as well as the assessor and laboratory perspectives. A brief presentation for each perspective followed by question and answers. MONDAY, SEPTEMBER 9, 2019 Wiley Award SYMPOSIUM: Advances in Analytical Methods for Botanical Dietary Supplements and for Clinical Nutritional Assessment 1:30 PM – 3:00 PM Grand Ballroom 1 Chair: Stephen A. Wise, National Institutes of Health 1:30 PM High-Throughput Affinity Selection— Mass Spectrometry Identification of Pharmacologically Active Natural Products in Complex Mixtures Richard B. van Breemen, Linus Pauling Institute, Oregon State University As faster alternatives to bioassay-guided fractionation, various affinity selection-mass spectrometry (AS-MS) methods are being used for the isolation, characterization, and identification of pharmacologically active compounds in complex natural prod- uct mixtures such as botanical and microbial extracts. AS-MS screening of combinatorial library pools is also an alternative to high-throughput screening of one compound per well. The most successful of these approaches include size exclusion chroma- tography LCMS (SEC MS), pulsed ultrafiltration (PUF-MS), and magnetic microbead affinity selection screening (MagMASS). In addition to facilitating the characterization and identification of compounds binding to active sites of enzymes and recep- tors, AS-MS is useful for the discovery of compounds that bind allosterically. Originally requiring manual sample handling and data analysis, the productivity of AS-MS has been enhanced recently by incorporating multititer well plate format, automated sample preparation and affinity selection, substituting UHPLC for HPLC, automating data analysis using metabolomics software, and automating dereplication software to search natural product databases.

3:00 PM – 4:30 PM Governor’s Square 14 Chairs: Brad Stawick, SGS North America, Inc.

John Szpylka, Mérieux NutriSciences Corporation Trace McInturff, A2LA - American Association for Laboratory Accreditation Colleen Cotter, CALA Brad Stawick, SGS North America, Inc.

6 SEPTEMBER 6–12, 2019 SHERATON DENVER DOWNTOWN HOTEL