AOAC 2018 Preliminary Program

PRELIMINARY PROGRAM

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BUILDING GLOBAL CONFIDENCE in Analytical Solutions

132 nd Annual Meeting & Exposition August 26 – 29, 2018 Sheraton Centre Toronto Hotel

TABLE OF CONTENTS

4

Acknowledgements

5 Welcome from the President of AOAC INTERNATIONAL 6 Schedule at a Glance 8 Keynote Address 9 H.W. Wiley Award Address 11 Stakeholder Panels 14 Exposition & Exhibitor/Partner Presentation Information 16 Scientific Sessions 27 Poster Presentations 34 Special Events 36 Meeting & Travel Information 37 Taking in Toronto 39 Registration Information

AOAC INTERNATIONAL is a globally recognized, 501(c)(3), independent , third party, not-for-profit association and voluntary consensus standards developing organization founded in 1884. When analytical needs arise within a community or industry, AOAC INTERNATIONAL is the forum for finding appropriate science-based solutions through the development of microbiological and chemical standards. AOAC standards are used globally to promote trade and to facilitate public health and safety.

2 AUGUST 26 – 29, 2018 SHERATON CENTRE TORONTO HOTEL

Why Attend the 132 ND AOAC ANNUAL MEETING?

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The greatest minds, talent, innovations, and solutions for methods based science are found at the AOAC INTERNATIONAL Annual Meeting & Exposition. This once a year event is unlike any other you will attend within the industry. EDUCATE. NETWORK. COLLABORATE. The AOAC Annual Meeting & Exposition is the epitome of those three words. AOAC and the standards-based scientific community have evolved. The future of AOAC is to provide solutions and to take on the global goal within our community to advance science by establishing standards and approving more methods FASTER… so that our member companies, our individual scientist members, and all others associated with the methods process can experience the fruits of their labor. The AOAC Annual Meeting & Exposition is the one source where the industry gathers to learn and collaborate on the past, present, and future of science and the business of analytical, scientific evaluation. HIGHLIGHTS : • Nearly 900 attendees • More than 60 exhibiting companies • 15 Exhibitor Presentations • 300 posters • Open access to all member community meetings • 30 scientific sessions ranging in a variety of topics in food safety and security • Sunday workshop included in registration fees • Networking receptions on Sunday, Monday, and Wednesday • More than 30% of attendees coming from outside the US For 2018, the AOAC Annual Meeting & Exposition‘s education is the most relevant and impactful lineup of scientific sessions and poster presentations we have offered to date. We are very proud of our exhibitor list and excited for you to meet with them and learn about their products and services and to collaborate with them to stay on top of the most cutting-edge trends and innovations within our industry. Whether you are a long time AOAC Annual Meeting attendee or an industry professional curious and interested in what AOAC is all about and wondering where a relationship with the organization might fit into your professional agenda, we invite you to attend and experience the 2018 Annual Meeting & Exposition. We are confident that your attendance will be time well spent. The best minds, talent, innovations, and solutions sharing a common goal…to approve, establish global standards, and advance science. REGISTER TODAY TO SHARE IN THE EXPERIENCE! share in the experience! Register today to

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ACKNOWLEDGMENTS 2017–18 AOAC TECHNICAL PROGRAMMING COUNCIL AOAC wishes to express its sincere thanks to the members of the Technical Programming Council for their efforts in developing and coordinating the technical program for this year’s Annual Meeting. Alexander Krynitsky, Chair Symbiotic Research LLC Michael McLaughlin, Vice Chair FDA – ORA/ORS Patrick Bird, Member Q Laboratories, Inc. Aniko Solyom, Member GAAS Analytical Carmen Diaz-Amigo, Member FOCOS GbR Jane Weitzel, Member Independent Consultant John Szpylka, Member Mérieux NutriSciences Corporation Jian Wang, Member Canadian Food Inspection Agency Melissa Phillips, Member NIST Erin Crowley, Ex-Officio Member Q Laboratories, Inc. 2017–18 AOAC INTERNATIONAL BOARD OF DIRECTORS DeAnn Benesh, President 3M Food Safety Saint Paul, MN, USA Brad Goskowicz, President-Elect Microbiologics, Inc. Saint Cloud, MN, USA Ron L. Johnson, Past President bioMérieux, Inc. Hazelwood, MO, USA Jonathan W. DeVries, Treasurer Medallion Laboratories/General Mills (Retired) Minneapolis, MN, USA Darryl M. Sullivan, Secretary Covance Laboratories Madison, WI, USA Michael Brodsky, Director Brodsky Consultants Thornhill, Ontario, CANADA Lei Bao, Director Nestlé Food Safety Institute Beijing, Peoples Republic of China Samuel Benrejeb Godefroy, Director University Laval Quebec City, Canada Clay Detlefson, Director National Milk Producers Federation Arlington, VA, USA Anthony J. Lupo, Director Neogen Corporation Lansing, MI, USA Daniel S. Fabricant, Director-at-Large Natural Products Association Washington, DC, USA Daniel Schmitz, Director-at-Large Abbott Nutrition Columbus, OH, USA Stephen A. Wise, Director-at-Large NIH Office of Dietary Supplements Bethesda, MD, USA David B. Schmidt, Executive Director AOAC INTERNATIONAL Rockville, MD, USA

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WELCOME FROM THE PRESIDENT of AOAC INTERNATIONAL

On behalf of the entire Board of Directors and staff of AOAC INTERNATIONAL, I am pleased to welcome you to the 132th Annual Meeting and Exposition in Toronto, Canada. It seemed to me that our new AOAC Mission Statement exactly describes our AOAC Annual Meetings: “As a leader of analytical excellence, AOAC INTERNATIONAL advances food safety, food integrity, and public health, by bringing together members, organizations, and experts dedicated to developing and validating standards, methods and technologies, of global relevance. ” With our new Executive Director, Mr. David Schmidt now in place, and our business plan underway, we look forward to a new chapter in AOAC INTERNATIONAL’s history, and are excited for you to have the opportunity to meet Dave at this Annual Meeting! AOAC is honored to announce this year’s keynote speaker, Dr. Aline Dimitri, Executive Director, Food Safety Science Directorate, and Deputy Chief Food Safety Officer at the Canadian Food Inspection Agency (CFIA). Dr. Dimitri is responsible for providing science advice, scientific risk intelligence, and overall science direction to inform policy analysis, program design, algorithm development and operational decision-making in the area of food; and is also responsible for designing food safety surveillance and monitoring programs, as well as providing leadership on the food research agenda for the CFIA. In her capacity as Deputy Chief Food Safety Officer, Dr. Dimitri is responsible for facilitating collaboration between federal departments and provincial partners in food safety and provides leadership to high profile initiatives such as Food Fraud. The Harvey W. Wiley Award is AOAC INTERNATIONAL’s top scientific honor, given annually for career accomplishments in analytical sciences. This year’s winner of the Harvey W. Wiley award, is Dr. Ikhlas Khan, director of the National Center for Natural Products Research (NCNPR) at the University of Mississippi, Oxford, Mississippi, USA. Please plan to attend the Wiley Award Address, where he will focus on examining methodologies for determining the quality and purity of dietary supplements, nutraceuticals, and other products placed on the market as using natural ingredients — stressing the importance of the quality of the test materials needed for precise and accurate analysis. The Horwitz Award was established in 1995 to honor the extraordinary contributions made by William Horwitz. It is

only presented when a truly qualified candidate is identified, who demonstrates extreme dedication and commitment to the Association. The Horwitz award will be presented this year for the first time in its history, to Dr. Albert E. Pohland. Please make time to introduce yourself to Dr. Al Pohland and thank him for his dedication to AOAC!

We continue to have more scientific sessions submitted each year than we can fit into the allotted meeting time, so the sessions you will find on the agenda, are ones that the Technical Programming Council deemed to be exceptional! Please look over the Program and carefully plan your time to attend as many as possible — but save time for the poster presentations, as well! I would like to take this opportunity to especially thank the meeting sponsors, partners and exhibitors. Based on feedback from our members and exhibitors, there will be no scientific sessions scheduled from 12:00 pm – 3:00 pm on Monday, August 27th and Tuesday, August 28. This will give attendees uninterrupted time in the Exhibit Hall, checking out the latest technological developments and services to help you with your analytical needs, while munching on box lunches that will be provided. And don’t just hang out with the people you already know at the Annual Meeting — take time to attend the many networking opportunities, and meet new colleagues, contacts, and friends! Sit in on one of the International Section meetings one evening to learn about needs and concerns in other global regions. Please take full advantage of all the opportunities that the AOAC Annual Meeting offers. I look forward to seeing you at the Exhibit Hall Grand Opening and President’s Welcome Reception on Sunday evening, August 26, to kick off the 132nd AOAC Annual Meeting and Exposition! Sincerely,

DeAnn Benesh President AOAC INTERNATIONAL

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SCHEDULE AT A GLANCE

FRIDAY, AUGUST 24, 2018 7:30 am – 9:00 am Pre-Conference Event Registration 8:30 am – 12:00 pm AOAC Stakeholder Panel on Dietary Supplements (SPDS) Meeting

10:00 am – 11:30 am 11:30 am – 12:00 pm 12:00 pm – 1:00 pm 12:00 pm – 1:00 pm 12:00 pm – 3:00 pm 12:00 pm – 5:00 pm 12:30 pm – 1:00 pm 1:00 pm – 2:00 pm 1:00 pm – 2:30 pm 1:00 pm – 3:00 pm 1:30 pm – 2:00 pm 2:00 pm – 2:30 pm 2:30 pm – 3:00 pm 3:00 pm – 3:30 pm 3:30 pm – 5:00 pm

Keynote Address and Awards Ceremony

Exhibitor/Partner Presentation: Pickering Laboratories

Exhibitor/Partner Presentation: Agilent Technologies

Poster Author Presentations

Exhibit Hall

Poster Presentations: Microbiological Methods, Botanical & Dietary Supplements, and Food Nutrition & Food Allergens

SATURDAY, AUGUST 25, 2018 7:30 am – 9:00 am Pre-Conference Event Registration 8:30 am – 12:00 pm AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN) Meeting 8:30 am – 5:00 pm AOAC Expert Review Panel for Dietary Supplements 9:00 am – 5:00 pm Registration 12:00 pm – 1:30 pm Pre-Conference Event Registration 1:00 pm – 5:00 pm AOAC Expert Review Panel for SPIFAN Nutrient Methods SUNDAY, AUGUST 26, 2018 7:30 am – 9:00 am Pre-Conference Event Registration 7:30 am – 8:00 pm Registration 8:30 am – 12:00 pm AOAC Stakeholder Panel on Strategic Food Analytical Methods (SPSFAM) Meeting

Exhibitor Presentation: CEM Corporation

Latin America Section Business Meeting

Agricultural Materials Community Meeting

AOAC Research Institute Board of Directors Meeting

Exhibitor/Partner Presentation: Metrohm USA

Refreshment Break

Exhibitor/Partner Presentation: Eurofins

Wiley Award Address

Wiley Award Symposium: Molecular Approaches to Botanical Authentication Symposium: Challenges in Microbiological Rapid Method Application Symposium: Worldwide Perspectives on Contaminants Testing in Food and Environmental Samples Using Advanced Analytical Techniques Symposium: Advanced Elemental Analysis Topics Applied to Foods and Pharmaceuticals

3:30 pm – 5:00 pm

3:30 pm – 5:00 pm

8:30 am – 12:30 pm

AOAC International Stakeholder Panel on Alternative Methods (ISPAM) Meeting

3:30 pm – 5:00 pm

12:00 pm – 1:30 pm 1:00 pm – 2:30 pm

Pre-Conference Event Registration

4:00 pm – 7:00 pm 5:00 pm – 5:30 pm 5:00 pm – 6:30 pm

AOAC Research Institute Expert Review Panel

Workshop: Challenges to Achieving Measurement Equivalence of Milk Protein Allergens in Food

Exhibitor Presentation: VUV Analytics

New Member and First-Time Attendee Welcoming Reception

1:00 pm – 4:00 pm 3:00 pm – 4:30 pm

AOAC Expert Review Panel for SPSFAM

TDLM/TDRMWorkshop: Preparing Laboratories for the Updated ISO/IEC 17025:2017 Standard AOAC INTERNATIONAL Board of Directors Meeting

5:00 pm – 6:30 pm 5:00 pm – 7:00 pm

ALACC Meeting

Chemical Contaminants and Residues in Food Community Meeting

3:00 pm – 5:00 pm 4:00 pm – 4:45 pm

New Member and First Time Meeting Attendee Orientation Exhibit Hall Grand Opening & President's Welcome Reception

6:00 pm – 7:00 pm 6:00 pm – 7:00 pm 6:30 pm – 7:30 pm 6:30 pm – 7:30 pm 7:00 pm – 8:00 pm

Taiwan Section Business Meeting

Japan Section Business Meeting

7:00 pm – 9:00 pm

Reception for TDLMMembers

Central Section Business Meeting

Joint Asian Sections Business Meeting

MONDAY, AUGUST 27, 2018 7:15 am – 8:15 am TDRM Executive Committee Meeting 7:30 am – 8:00 am Exhibitor/Partner Presentation: SCIEX 7:30 am – 5:00 pm Registration 7:45 am – 8:15 am Continental Breakfast 8:15 am – 9:45 am

TUESDAY, AUGUST 28, 2018 7:00 am – 8:00 am

Exhibitor/Partner Presentation: Waters Corporation

7:30 am – 8:00 am

Exhibitor/Partner Presentation: Thermo Fisher Scientific

Symposium: How Can Interlaboratory Studies Help your Laboratory and the Community At-Large? Symposium: Practicality of Quantitative NMR in Quality Control Symposium: Application of Novel Methodologies and Technologies to the Detection of Unknown Chemical Contaminants in Foods

7:30 am – 5:00 pm 7:45 am – 8:15 am 8:00 am – 12:30 pm 8:15 am – 9:45 am

Registration

Refreshment Break

8:15 am – 9:45 am

AOAC Research Institute Expert Review Panel

8:15 am – 9:45 am

Symposium: Statistical Tools for Improving Laboratory and Collaborative Study Methodologies

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8:15 am – 9:4 am

Roundtable: Breaking New Ground — Consumer Analytical Devices Hot Topic Symposium: Food Fraud — A Global Challenge. How Can Analytics Help? What are the Limitations? Partner Presentation: Covance Laboratories Poster Presentations: Analysis of Foodbourne Contaminants & Residues and Analysis of Non- Foodbourne Contaminants & Residues Symposium: Which Multi-Class/Multi-Residue Method Strategies are Applicable for Veterinary Drug Residues Control in Foods? Multi-Target Screening and Multi-Confirmatory Quantification Symposium: What Does Gluten Mean from the Analytical Perspective? Symposium: Ensuring Food Protection — New Analytical Advances in Detection Methods Bringing Routine Closer than Ever Refreshment Break

8:15 am – 9:45 am

9:45 am – 10:15 am 9:45 am – 10:15 am 10:00a m – 5:00 pm

WEDNESDAY, AUGUST 29, 2018 7:30 am – 8:00 am Exhibitor Presentation: Phenomenex 7:45 am – 8:15 am Refreshment Break 8:00 am – 12:00 pm Registration 8:15 am – 9:45 am Symposium: New Blood 2018 - Developing Methods for the Detection of Important Chemical Analytes, Residues and Contaminants

10:15 am – 11:45 am

10:15 am – 11:45 am

8:15 am – 9:45 am

Roundtable: Opportunities and Challenges in Botanical Ingredient Traceability Efforts — Selecting the Right Test Method for the Specification Symposium: Microbiology Method Validation and Implementation — A Canadian Perspective

10:15 am – 11:45 am

8:15 am – 9:45 am

10:15 am – 11:45 am 11:45 am – 1:15 pm 12:00 pm – 12:30 pm 12:00 pm – 1:00 pm 12:00 pm – 2:30 pm 12:00 pm – 3:00 pm 12:30 pm – 2:30 pm 1:00 pm – 1:30 pm 1:00 pm – 3:00 pm 1:30 pm – 2:30 pm 1:30 pm – 3:00 pm 2:00 pm – 2:30 pm 2:00 pm – 2:30 pm 3:00 pm – 4:30 pm

What Drives AOAC Sections around the World?

9:45 am – 10:15 am 10:00 am – 12:00 pm

Refreshment Break

Contaminants Subgroup Meeting — Veterinary Drugs

AOAC Method Validation: Recent Trends and Recommendations

Exhibitor/Partner Presentation: MilliporeSigma

Poster Author Presentations

10:00 am – 5:00 pm

Poster Presentations: Environmental Analysis, Authenticity & Food Fraud, Detection & Measurement of Natural Toxins, General Methods, Quality Assurance & Accreditation, and Performance Tested Methods TM Symposium: “Green” Chemistry — Testing Cannabis for Safety and Quality Symposium: Solving Everyday Problems in the Dietary Supplement Analytical Laboratory without Breaking the Bank Symposium: Advanced Listeria Detection and Control — What’s the State of the Art Today? Symposium: ISO 17025:2017 — It’s a Whole New Ballgame…Or Is It? Symposium: Reference Materials in Natural Product Science — Critical Uses in Laboratory Quality Control, Research, and Performance Assessment Workshop: AOAC Microbiology Method Validation Guidance — Review of Guidance, Recent Trends, and Decisions Symposium: Can Quality Be Assured by Analytical Laboratories Testing Cannabis? Symposium: Qualification of Certified and In-House Botanical Reference Material for Intended Use in Botanical Identification Technical Programming Council Meeting Poster Author Presentations Refreshment Break

Committee on Sections Meeting

Exhibit Hall

AOAC Research Institute Advisory Council Meeting

10:15 am – 11:45 am

Exhibitor/Partner Presentation: U.S. Pharmacopeia

10:15 am – 11:45 am

AOAC Committee on Statistics Meeting

TDLM Executive Committee Meeting

Contaminants Subgroup Meeting — Environmental and Emerging Contaminants

10:15 am – 11:45 am

Exhibitor/Partner Presentation: Eurofins

11:45 am – 1:00 pm 12:00 pm – 1:00 pm 1:00 pm – 2:30 pm

Refreshment Break

Symposium: Characterization of Micro-Organisms by WGS & MALDI-TOF Technologies — The Roadmap to the 21st Century Adoption Symposium: Mycotoxins and Food Safety-Prevention and Control — Expectation and Reality

1:00 pm – 2:30 pm

3:00 pm – 4:30 pm

3:00 pm – 4:30 pm

Symposium: Protein Qualitative and Quantitative Analysis

1:00 pm – 2:30 pm

3:00 pm – 5:00 pm 4:30 pm – 5:00 pm 4:30 pm – 6:00 pm 4:30 pm – 6:00 pm 4:30 pm – 7:30 pm 4:45 pm – 6:45 pm 5:00 pm – 6:00 pm 5:00 pm – 6:00 pm 5:00 pm – 6:30 pm 6:00 pm – 7:00 pm

AOAC Research Institute Expert Review Panel

2:30 pm – 3:00 pm 3:00 pm – 4:30 pm

Exhibitor Presentation: bioMérieux

Contaminants Subgroup Meeting - Pesticides

Membership Committee Meeting

3:00 pm – 4:30 pm

Mycotoxin Community Meeting

Food Allergen Community Meeting

3:00 pm – 4:30 pm

Symposium: Novel Analytical Methods for New Carbohydrates AOAC INTERNATIONAL Business Meeting

Color Additives Meeting

TDRMMembers Meeting

4:30 pm – 6:00 pm 8:00 pm – 11:00 pm

Europe Section Executive Committee Meeting

Annual Meeting Closing Reception

TDRMMembers Reception, co-sponsored by FONA, Mérieux NutriSciences, and MilliporeSigma

6:15 pm – 7:45 pm 6:30 pm – 7:30 pm

Contaminants Subgroup Meeting — Metals

THURSDAY, AUGUST 30, 2018 8:00 am – 12:00 pm Editorial Board Meeting 9:00 am – 1:00 pm AOAC Official Methods Board Meeting

China Section Business Meeting

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KEYNOTE ADDRESS Building Trust Together

MONDAY, AUGUST 27, 2018 10:00am – 1 1 :30am Aline Dimitri, Deputy Chief Food Safety Officer, Executive Director, Food Safety Science Directorate, Science Branch, CFIA

The Canadian Food Inspection Agency (CFIA) works with other government organizations, industry and academia to support and develop science that contributes to evidence-based decisions that protect Canada’s food, animal and plant resources. In her role as Deputy Chief Food Safety Officer, Dr. Aline Dimitri strives to improve transparency by providing relevant information in a way that citizens can understand. This involves explaining what the agency does, and why. As a regulatory Agency, the CFIA tests tens of thousands of food samples every year. These test results are critical because they impact and influence food safety, Canadian business and international trade. For this reason, the CFIA relies on a network of accredited laboratories that use fit for purpose and validated methods to generate defensible testing results. This is a key element, within the broader food safety system, where AOAC International plays an import- ant role. Dr. Dimitri will discuss transparency, sound science and international collaboration as essential elements to build public trust. About Aline Dimitri Aline Dimitri is the Executive Director of the Food Safety Science Directorate and the Deputy Chief Food Safety Officer at the Canadian Food Inspection Agency (CFIA). Dr. Dimitri is responsible for providing science advice, scientific risk intelligence, and overall science direction to inform policy analysis, program design, algorithm development and operational decision-making in the area of food. She is also responsible for designing food safety surveillance and monitoring programs, such as the National Chemical Residue Program and the National Microbiological Monitoring Program, as well as providing leadership on the food research agenda for the CFIA. As the executive lead of the Antimicrobial Resistance (AMR) initiative within CFIA, she collaborates extensively across the Government of Canada, with international partners, and with stakeholders in the development and implementation of the pan-Canadian action plan in response to the global threat of AMR. In her capacity as Deputy Chief Food Safety Officer, Dr. Dimitri is responsible for facilitating collaboration between federal departments and provincial partners in the area of food safety and provides leadership to high profile initiatives as such as Food Fraud. Aline is a graduate of McGill University where she received her Ph.D. in Food Science. Throughout her career, she has gained a wide range of experience in the areas of policy design and program delivery in highly complex scientific and corporate areas.

8 AUGUST 26 – 29, 2018 SHERATON CENTRE TORONTO HOTEL

WILEY AWARD ADDRESS Need for a Comprehensive Approach to Assess Quality of Dietary Supplements

MONDAY, AUGUST 27, 2018 3:00pm – 3:30pm Ikhlas Khan , Director, The National Center for Natural Products Research (NCNPR), University of Mississippi, Oxford Ikhlas Khan will deliver the Wiley Award Address at the AOAC Annual Meeting in Toronto, Canada, where he will examine methodologies for determining the quality and purity of dietary supplements, nutraceuticals, and other products placed on the market as using natural ingredients. He stresses the importance of quality of the test material for precise and accurate analysis. While research is focusing on determining the beneficial effects of traditional medicines and botanicals, it is becoming a priority that identity and authentication issues must be resolved, which requires a multidisciplinary effort. There has been an increase in interest in science- based research of botanical dietary supplements. To date, much of the research has been plagued by studies being conducted on unauthenticated, uncharacterized products. One of the most critical issues involved in any research study is the quality of the test material. A study cannot be considered scientifically valid if the material tested was not authenticated and characterized such that the material can be reproduced. In the case of botanicals, there may be misidentification of the collected plant, adulteration with other species, or contamination with extraneous ingredients. From the perspective of a regulatory action, these cases may range from misleading labeling to safety because of toxic contaminants. From the scientific community’s perspective, lack of authentication and characterization of study materials has resulted in a considerable amount of published work that is not reproducible, inconsistent, and contradictory. It can often be difficult to compare reported efficacy or toxicity studies even when ‘standardized’ material has been used. Many studies refer to the use of standardized material, which usually implies chemical standardization. While chemical standardization is important, it has limited utility when the starting material is not well-characterized botanically.

Continued on page 10

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WILEY AWARD ADDRESS (Continued)

During the Wiley Award Address, Khan will highlight efforts undertaken in his research center. Analytical tools can be applied to measure the exact amount of a particular marker/biomarker compound but, in most cases, it does not resolve the question of identity of the plant. Since a single approach is not adequate to address the unambiguous identity of a botanical, the NCNPR is undertaking a comprehensive approach utilizing morphological/ anatomical/ genetics and chemical analysis methods, to address this issue. The Harvey W. Wiley Award is AOAC INTERNATIONAL’s top scientific honor, given annually for career accomplishments in the analytical sciences.

About I kh l as Khan Ikhlas Khan is director of the National Center for Natural Products Research at the University of Mississippi, Oxford, Mississippi, USA. Khan began his career at the University of Mississippi in 1992 as a research scientist. His primary research interests include analytical fingerprinting for standardization of herbal products and bioanalytical approaches to improvement of product quality and safety. He has received numerous awards, including Fellow of the Royal Society of Chemistry and the American Institute Chemists. He has authored/co-authored over 700 research articles. Khan received a B.Sc. in Chemistry in 1980 and an M.Sc. in Organic Chemistry in 1982 from Aligarh Muslim University in Aligarh, India, and a Ph.D. in Pharmacy in 1987 from Institute for Pharmaceutical Biology in Munich, Germany. He held postdoctoral positions at the University of Mississippi and at the Swiss Federal Institute of Technology in Zurich.

10 AUGUST 26 – 29, 2018 SHERATON CENTRE TORONTO HOTEL

ATTEND THE PRE-CONFERENCE AOAC STAKEHOLDER PANELS FRIDAY, SATURDAY AND SUNDAY **See page 39 for complete registration details

AOAC has established several consensus panels to empower the industry(s) to take the lead on providing solutions to global issues. These panels serve as a science-based, open and neutral forums where global stakeholders from govern- ment, industry and academia convene to identify issues and articulate standard method performance requirements (SMPRs) needed for eliminating trade barriers; substantiating health claims; and meeting and/or establishing regulatory requirements. These panels will meet on August 24–26, 2018, prior to the AOAC Annual Meeting & Exposition. Register separately for these pre-conference panels.

STAKEHOLDER PANEL ON DIETARY SUPPLEMENTS (SPDS) August 24, 2018, 8:30 am – 12:00 pm

The dietary supplements community is working collaboratively to identify and prioritize ingredients and develop volun- tary consensus standards. For more information, visit www.aoac.org and click the tab “Standards Development”, then “Stakeholder Panel on Dietary Supplements (SPDS)”. Contact: Dawn Frazier at dfrazier@aoac.org or 301-924-7077, ext. 117.

STAKEHOLDER PANEL ON INFANT FORMULA AND ADULT NUTRITIONALS (SPIFAN) August 25, 2018, 8:30 am – 12:00 pm

The global infant formula community is in the process of developing voluntary consensus standards for global dispute resolution methods. For more information, visit www.aoac.org and click the tab “Standards Development”, then “Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN)”. Contact: Alicia Meiklejohn at ameiklejohn@aoac.org or 301-924-7077, ext. 101.

STAKEHOLDER PANEL ON STRATEGIC FOOD ANALYTICAL METHODS (SPSFAM) August 26, 2018, 8:30 am – 12:00 pm

AOAC is bringing the food industry together to lead the charge to develop much needed standards and methods that promote food safety, food security, and facilitate trade. For more information, visit www.aoac.org and click the tab “Standards Development”, then “Stakeholder Panel on Strategic Food Analytical Methods (SPSFAM). Contact: Dawn L. Frazier at dfrazier@aoac.org or 301-324-7077, ext. 117.

INTERNATIONAL STAKEHOLDER PANEL ON ALTERNATIVE METHODS ( ISPAM) August 26, 2018, 8:30 am – 12:30 pm

ISPAM’s focus is to develop harmonized, internationally accepted standard validation guidelines for alternative (rapid) chemical and microbiological methods by leveraging global networks of experts to reach consensus on an analytical validation protocol. For more information, visit www.aoac.org and click the tab “Standards Development”, then “International Stakeholder Panel on Alternative Methodology (ISPAM)”. Contact: Krystyna McIver at kmciver@aoac.org or 301-924-7077, ext. 111.

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AOAC

Educate Network Collaborate

L e a d i n g t h e I n d u s t r y i n F o o d S c i e n c e a n d S a f e t y This is how the top of the page could look, with the “AOAC” and the “Collaborate, Network, and Educate” .

Proficiency Testing

The Laboratory Proficiency Testing Program comes with AOAC INTERNATIONAL’s commitment to provide:

Graphics below-­‐from Adobe Stock. I have already purchased the one with the globe and the chemical formulas on it from prior use. However, I think the one with the tomatoes is better. Both are in my library at Adobe account. Other graphics that can be used in smaller areas or at the bottom include vegetables, cannabis, cheese, meat. AOAC Educate Network Collaborate

• An A2LA Accredited program since 2001 • Independent assessment of the accuracy and reliability of your analytical data • Testing samples delivered to your laboratory ready to analyze, like routine samples • Comprehensive testing programs offering a wide array of organisms, analytes and matrices • A Confidential and secure website to enter data • State-of-the-art electronic reports and Historical database • Statistics that follow ISO 13528 • Access to international quality experts

For more information visit www.AOAC.org today or contact staff at LPTP@AOAC.org

NEW

• Expanding programs to meet your quality assurance needs

For more information visit www.AOAC.org today or contact staff at LPTP@AOAC.org

To Enroll in Any AOAC Proficiency Testing Program Visit www.AOAC.org or Contact Staff at LPTP@AOAC.org

Microbiology Pesticide Residues Food Chemistry

Today’s analytical laboratories compete in a truly global marketplace. To succeed, an analytical laboratory must maintain the highest possible standard of accuracy and reliability. The AOAC INTERNATIONAL Laboratory Proficiency Testing Program enables laboratories to offer their products to markets worldwide. In fact, AOAC INTERNATIONAL has assumed a leadership role in providing proficiency testing programs to analytical laboratories. The program helps laboratories achieve international credibility and compliance. When high quality homogeneous stable samples are combined with a commitment to provide responsive technical support and detailed reports, the AOAC INTERNATIONAL Laboratory Proficiency Testing Program is the choice for analytical laboratories.

ACCREDITED Proficiency Testing Provider Certified Number 1782.01

12 AUGUST 26 – 29, 2018 SHERATON CENTRE TORONTO HOTEL

LEADING THE INDUSTRY in Food Science and Safety

New Proficiency Testing Program Nutrients in Infant Formula and Adult Nutritionals

Water Soluble Vitamins Vitamin C Vitamin B1 Vitamin B2 Vitamin B6 Vitamin B12 Pantothenic Acid (B5) Folic Acid Biotin

Vitamin A Vitamin D Vitamin E Vitamin K1 Oil Soluble Vitamins

Myo-Inositol Nucleotides Ultra Trace Minerals (Chromium, Selenium, and Molybdenum) Fatty Acids More Nutrients to be Added

NEW

Matrices and Nutrients align with Foods for Special Medical Purposes (FSMP) Each participating laboratory can submit results for up to two methods for each nutrient. Laboratories can choose to report results obtained using the current AOAC SPIFAN Official Method of Analysis (OMA) and/or an alternate routine method of analysis. The analyses deadline is 30 days. Result statistics follow ISO 13528 . Participants can test for as many nutrients as needed. Enroll now to be a part of the next shipment.

To Enroll Visit www.AOAC.org or Contact Staff at LPTP@AOAC.org

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THE AOAC EXPOSITION

Designed to be an integral part of your Annual Meeting experience, the AOAC Exposition has a superb range of new services and technologies to examine. Over 50 leading suppliers to the analytical communities will be onsite. The Exposition offers an outstanding opportunity to learn about resources available to enhance both your individual and company performance.

EXHIBIT HALL HOURS Sunday, August 26, 2018

7:00 pm – 9:00 pm Exhibit Hall Grand Opening

& President’s Welcome Reception

Monday, August 27, 2018

12:00 pm – 3:00 pm

NEW TIMES!

Tuesday, August 28, 2018 12:00 pm – 3:00 pm AOAC has listened to your requests for additional time to visit the Exhibit Hall. AOAC will not hold scientific sessions from 12:00 pm – 3:00 pm on Monday or Tuesday. A light lunch will be served in the Exhibit Hall on both days. Please use this time to visit the wonderful collection of vendors in the Hall.

EXHIBITORS Following is a list of exhibitors confirmed as of press time. Please visit the AOAC web site at www.aoac.org to see additional exhibitors as they are added. If your organization is interested in exhibiting and/or sponsoring an event at the meeting, please contact Lauren Chelf at lchelf@aoac.org or 240-912-1449. A2LA

Deibel Laboratories Develosil USA

Accreditation Inc. (PJLA) Phenomenex Pickering Laboratories, Inc. QuoData GmbH Randox Food Diagnostics Restek Corporation Sartorius SCIEX Shimadzu Scientific Instruments, Inc. SPEX SamplePrep Thermo Fisher Scientific USP Verder Scientific, Inc VUV Analytics Waters Corporation Xylem Analytics

Agilent Technologies AGS Scientific, Inc. Alkemist Labs American Proficiency Institute Group, Inc. ANAB ATS Scientific Inc. bioMérieux, Inc. Biotage BIPEA

Elemental Scientific, Inc. ELISA Technologies, Inc.

Eurofins SFA Laboratories, Inc. Interscience Laboratories Inc. IsoSciences LECO Corporation LGC Standards Megazyme Merq Inc Metrohm MilliporeSigma NIST o2si smart solutions PerkinElmer Perry Johnson Laboratory

Bruker Corporation Camag Scientific, Inc. Canadian Life Science Cedarlane CEM Corporation Chemical Solutions Ltd

14 AUGUST 26 – 29, 2018 SHERATON CENTRE TORONTO HOTEL

EXHIBITOR/PARTNER PRESENTATIONS AOAC Annual Meeting exhibitors and partners will hold Presentations throughout the Meeting. This venue allows more in-depth interaction and one-on-one contact between attendees and exhibiting companies. Companies will be showcasing new products, new technologies, and offering product demonstrations--you won’t want to miss this opportunity. Stop by an Exhibitor/Partner Presentation and learn more about the following companies’ products and services. MONDAY, AUGUST 27, 2018 7:30 am – SCIEX

11:30 am – Pickering Laboratories 12:30 pm – Agilent Technologies 12:30 pm – CEM Corporation 1:30 pm – Metrohm USA 2:30 pm – Eurofins 5:00 pm – VUV Analytics

TUESDAY, AUGUST 28, 2018 7:00 am – Waters Corporation

7:30 am – Thermo Fisher Scientific 9:45 am – Covance Laboratories 12:00 pm – MilliporeSigma 1:00 pm – U.S. Pharmacopeia 2:00 pm – Eurofins 4:30 pm – bioMérieux, Inc.

WEDNESDAY, AUGUST 29, 2018 7:30 am – Phenomenex

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SCIENTIFIC SESSIONS

SUNDAY, AUGUST 26, 2018 1:00 pm – 2:30 pm Workshop: Challenges to Achieving Measurement Equivalence of Milk Protein Allergens in Food

• John Szpylka, Mérieux NutriSciences Corporation Responding in Time to the New Structure and Components of ISO/IEC 17025:2017 • Håkan Emteborg, European Commission – Joint Research Centre The Reference Material Toolbox: What Do You Need to Make One? • Brad Stawick, SGS North America, Inc. The Microbiological Testing Process Side of ISO/IEC 17025 MONDAY, AUGUST 27, 2018 8:15 am – 9:45 am Symposium: Application of Novel Methodologies and Technologies to the Detection of Unknown Chemical Contaminants in Foods The identification of unknown chemical contaminants in foods is a challenge. Many cases of intentional contamination have been clearly documented and shown to compromise food safety and quality. For instance, the artificial augmentation of the protein content of milk powder using nitrogen-rich melamine sickened hundreds of thousands of children and caused six fatalities in China in 2008. Other examples of serious health threats include the dilution of spices with lead chromate and lead tetroxide, the substitution of Chinese star anise with toxic Japanese star anise, the adulteration of vodka with anti-freeze, the painting of table olives with a copper sulfate solution to enhance their green color, the fraudulent addition of toxic and carcinogenic dyes, such as Sudan Red, to hot chili powders, and the suspected tampering and contami- nation of olive oil that killed over 300 people in Spain in 1981. Applying traditional targeted quantitative analytical methods requires prior knowledge of a potential contaminant and is often time consuming and inappropriate for the high-through- put screening needed to authenticate shipments of foods. Therefore, it is critically important to develop and validate non-targeted, screening procedures for characterizing the properties, including quality, of authentic food matrices and methodologies capable of rapidly predicting the presence of unknown potential chemical contaminants. Most non-targeted procedures entail the development of newer rapid methodol- ogies that require multivariate statistical data analyses capable of recognizing deviations from the expected output associated with authentic food matrices. CO-CHAIR: Magdi Mossoba, U.S. Food and Drug Administration CO-CHAIR: Luis Rodriguez-Saona, The Ohio State University • Magdi Mossoba, U.S. Food and Drug Administration Comparative Study of Official Methods and Proposed Rapid Vibrational Spectroscopic and Chemometric Screening Procedures for the Authentication of Olive Oil

The workshop will address the measurement of milk aller- gen proteins in foods using both immunoassay and mass spectrometry-based approaches. The challenges to achieve measurement equivalence within and between measurement approaches will be discussed. CO-CHAIR: David Bunk, U.S. National Institute of Standards and Technology CO-CHAIR: Ashley Beasley Green, U.S. National Institute of Standards and Technology CO-CHAIR: Melissa Phillips, U.S. National Institute of Standards and Technology • Peter Scholl, U.S. Food and Drug Administration Milk Protein Chemistry in Foods • Sefat Khuda, U.S. Food and Drug Administration ELISA-Based Measurement of Milk in Foods • Jerry Zweigenbaum, Agilent Technologies, Inc. MS-Based Measurement of Milk in Foods • Phil Johnson, University of Nebraska Interlaboratory Evaluations of Milk Measurements in Foods 3:00 pm – 4:30 pm ISO/IEC 17025 has become the global standard for accred- iting an analytical laboratory’s quality system. This standard covers many aspects of lab operations and also has a key strength of evolving alongside laboratories as their services expand, as analytical results become more involved in global activities, and as analytical data is used in emerging initiatives. ISO/IEC 17025 has released its 2017 version with significant changes that must be incorporated in laboratories maintain- ing or adopting this standard. To continue to support the industry, AOACI’s Guidelines for Laboratories Performing Microbiological and Chemical Analyses of Food, Dietary Supplements, and Pharmaceuticals was updated in response to the new ISO/IEC 17025 standard. This workshop will review key upgrades to ISO/IEC 17025:2017 including using a process approach, emphasizing the lab’s process instead of a list of tasks, and incorporating risk-based thinking. Scenarios will be presented which highlight these upgrades and lab responses will be formulated by workshop attendees. CO-CHAIR: John Szpylka, Mérieux NutriSciences Corporation CO-CHAIR: Brad Stawick, SGS North America, Inc. TDLM/TDRMWorkshop: Preparing Laboratories for the Updated ISO/IEC 17025:2017 Standard

16 AUGUST 26 – 29, 2018 SHERATON CENTRE TORONTO HOTEL

• Luis Rodriguez-Saona, The Ohio State University Handheld and Portable Devices for in-situ Screening of Chemical Contaminants: Point-and-Shoot Capabilities of Vibrational Spectroscopy Combined with Pattern Recognition Techniques • James Harnly, U.S. Department of Agriculture The 3 Fundamentals of Non-Targeted Analysis: Reference Samples, Chemical Fingerprinting, and One-Class Modeling • Kenny Xie, U.S. Pharmacopeia (USP) Non-Targeted Detection of Milk Powder Adulteration by 1H NMR Spectroscopy and Conformity Index Analysis • Ashraf Ismail, McGill University Infrared Spectroscopic Methods for Detection of Adulterants in Raw Milk • Marcal Plans Pujolras, Nestlé Purina Uses of NIR Spectroscopy for Economically Motivated Adulteration (EMA) in Pet Food Industry Symposium: Quantitative NMR in Quality Control and Compendial Analysis The methodology and practice of quantitative NMR (qNMR) has seen significant advancements within the last decade following solidification of conceptual understanding, develop- ments in signal processing and software, as well as increased availability of moderately-priced sub-100 MHz, a.k.a. benchtop, instrumentation. It is evident that aforementioned advantages coupled with further developments in automation assemble into a compelling analytical platform, rivaling the position of chromatographic techniques. Growing recognition and acceptance of the methodology by analytical community, and propensity of the pharmacopoeias to incorporate qNMR procedures is a testament to the technique’s maturity and on overt acknowledgement of its powerful appeal. Dietary supplements, especially those of biogenic origin, are often exceedingly complex. It is for a reason that NMR and qNMR are frequently called upon as “techniques of last resort” with their notable ability to address matrices that challenge chromatographic paradigm and resolve difficulties with conventional detection: krill oil phospholipids, a dozen compo- nents of Aloe vera , complex botanical extracts and analytically challenging biopolymers are all known to benefit from use of NMR. Since 2014, Japanese Pharmacopoeia has been steadily introducing qNMR into natural product monographs, and using qNMR for reference standard purity assignment. National pharmacopoeias and metrological institutions are actively employing this primary relative technique. The session will review the appropriateness of qNMR to common anal- yses, provide overview of the state-of-the art hardware and software, touch upon the uniqueness of method validation and the use of reference materials in quantitation, and investigate its status within compendial analysis, with examples from Japanese and U.S. Pharmacopoeias. CO-CHAIR: Anton Bzhelyansky, U.S. Pharmacopeia (USP) CO-CHAIR: Tetsuhisa Goto, Central Scientific Commerce, Inc. • Toru Miura, FUJIFILM Wako Pure Chemical Corporation Quantitation Paradigm in qNMR and Preparation of Quantitative Reference Standards • Kristie Adams, Steelyard Analytics, Inc. FutureQC: Applications You’d Love Running

• John Edwards, Process NMR Associates Industrial qNMR Using Low-Field Instrumentation: Perspectives and Progress • Yang Liu, U.S. Pharmacopeia (USP) Pharmacopeial qNMR: Laying the Foundation for the Future of Compendial Analysis Symposium: How Can Interlaboratory Studies Help your Laboratory and the Community At-Large? Accurate and precise measurements are vital to confident decision making in the regulation of natural products. Many measurement service tools are available to help laboratories critically evaluate performance, including Official Methods of Analysis, reference materials, and interlaboratory stud- ies. Interlaboratory studies often follow a proficiency testing model used for the purpose of laboratory certification/ accreditation. The Chemical Sciences Division (CSD) at NIST provides interlaboratory studies for additional purposes including: establishing scientific validity of a method; uncovering method specific results and biases; evaluating commutability of reference materials; and performing collab- orative studies to gather multi-laboratory testing data to support recommendation of methods from first to final action. The programs are designed to be of use to laboratories large and small that support production of materials along all points in the supply chain. This session will explore the less commonly discussed benefits of interlaboratory studies. CO-CHAIR: Laura Wood, U.S. National Institute of Standards and Technology CO-CHAIR: Charles Barber, U.S. National Institute of Standards and Technology • Melissa Phillips, U.S. National Institute of Standards and Technology An Incremental Approach to Collaborative Studies using Quality Assurance Programs • Rupa Das, BI Nutraceuticals The Value of QAPs in Supply Chain Management • Donald Gilliland, Abbott Laboratories Use of Interlaboratory Studies to Evaluate Laboratory and Methods Performance – An Industry Perspective • Joseph Betz, National Institutes of Health The Benefits of QAPs from an NIH Perspective • Catherine Rimmer, U.S. National Institute of Standards and Technology Bringing It All Together HAMQAP

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3:00 pm – 3:30 pm Harvey W. Wiley Award Address: Need for a Comprehensive Approach to Assess Quality of Dietary Supplements • Ikhlas Khan, National Center for Natural Products Research,

• Jian Wang, Canadian Food Inspection Agency (CFIA) UHPLC/ESI Q-Orbitrap Target Screening of ~850 Pesticide Residues in Fruits and Vegetables using Data Independent Acquisition and Compound Database • Kazuaki Iijima, The Institute of Environmental Toxicology Japanese Perspectives on Contaminants Testing in Food and Environmental Samples Using Advanced Analytical Techniques Symposium: Advanced Elemental Analysis Topics Applied to Foods and Pharmaceuticals This session will focus on the application of advanced elemen- tal analysis methods and concepts to elemental contaminants in foods, and elemental analysis methods utilizing the prin- ciples of updated USP methods (232/2232). There will be three speakers, each discussing a different topical issue in the advanced elemental analysis, as well as some flash talks from the best elemental analysis related poster submissions from the conference. Each speaker is from a different background; there will be representatives from domestic and international government as well as industry presenting. Highlighted topics to be covered are nanoparticles and elemental speciation and their application in various matrices. CO-CHAIR: Jenny Nelson, Agilent Technologies, Inc. CO-CHAIR: Kevin Kubachka, U.S. Food and Drug Administration • Sean Conklin, U.S. Food and Drug Administration Arsenic Speciation Analysis in Seafood and Seaweed at FDA • Barbro Kollander, National Food Administration, Sweden Lead Nanoparticles in Game and Arsenic Species in Human Urine: Projects at National Food Agency Sweden • Michael Fricke, Michael Fricke INC The USP <232> Class 1 Element: Arsenic Symposium: Challenges in Rapid Microbiological Method Application Most rapid microbiological methods receive approval and accreditation after extensive development and validation processes. Application of rapid methods within the food industry is complicated by diverse sample matrix complexity and unforeseen analytical challenges presented throughout the production continuum. Food product categories and types for method validation purposes are broadly defined and do not often represent the matrices being tested. Producer’s may have multiple product SKUs within a category and type, however, the various formulations could differentially impact analyte propagation and subsequent diagnostic performance. Products, such as probiotic supplemented beverages, may not only be complicated due to competitive growth of the probiotic strain, but also by flavoring or other ingredients and their effects on method chemistry. Rapid method use can be challenged by unforeseen developments within the industry, such as the implementation and use of phage based process- ing aids for environmental control of Listeria . Many challenges exist to the real-world application of accredited, rapid microbi- ological methods which are often unanticipated and challenge “fit-for-purpose” use paradigms.

University of Mississippi 3:30 pm – 5:00 pm Wiley Award Symposium: Molecular Approaches to Botanical Authentication

This session will complement the Wiley Award Address by Dr. Ikhlas Khan. Dr. Khan has spearheaded efforts to develop and disseminate analytical methods for determination of poten- tially toxic constituents of dietary supplements and to develop and disseminate chromatographic methods for authentication of botanical dietary ingredients in raw materials and finished supplement products. The speakers in the Wiley Award Symposium will describe original approaches to botanical authentication and validation of these approaches. Subjects will include targeted and non-targeted phytochemical finger- printing, DNA authentication, comparison of strengths and weaknesses of the approaches, data interpretation, and determination of reliability for the purpose of botanical authentication. CHAIR: Joseph Betz, National Institutes of Health • Paula Brown, BCIT Chemoanalytical Approaches for Establishing Authenticity of Botanical Products • James Harnly, U.S. Department of Agriculture Targeted and Non-Targeted Phytochemical Fingerprinting for Botanical Authentication • Rahul Pawar, U.S. Food and Drug Administration Complementary Use of Chemical and DNA Barcoding Methods for Assessing the Authenticity of Herbal Dietary Supplements Symposium: Worldwide Perspectives on Contaminants Testing in Food and Environmental Samples Using Advanced Analytical Techniques This session will comprise of world experts who are at the forefront of modern contaminant analysis. The audience will learn about their experiences with utilization of advanced analytical techniques including but not limited to liquid or gas chromatography-high resolution mass spectrometry to identify and quantitate unknown residues in food and environmental matrices. Protocols used in the development and validation of multi-residue will also be presented and discussed. CO-CHAIR: Steven Moser, Oklahoma Department of Agriculture, Food & Forestry CO-CHAIR: Ping Wan, Office of Indiana State Chemist • Amadeo Fernández-Alba, University of Almeria EURL Experiences in Application of LC-HRMS for Pesticide Residues Analysis in Fruits and Vegetables

18 AUGUST 26 – 29, 2018 SHERATON CENTRE TORONTO HOTEL