AOAC CASP Meeting Book

SATURDAY, AUGUST 28, 2021 1:00PM – 5:00PM

at the

AOAC 2021 ANNUAL MEETING Sheraton Boston Hotel Boston, Massachusetts, USA

AOAC Annual Meeting Saturday, August 28, 2021 | 1:00pm – 5:00pm ET

Moderator: Christopher Dent, AOAC INTERNATIONAL

MEETING AGENDA

I. WELCOME, INTRODUCTIONS AND ANNOUNCEMENTS (1:00PM – 1:10PM) David Schmidt, AOAC INTERNATIONAL

II. PROGRAM REVIEW (1:10PM – 1:20PM) Christopher Dent, AOAC INTERNATIONAL

III. SMPR ORIENTATION (1:20PM – 1:30PM) Deborah McKenzie, AOAC INTERNATIONAL

IV. AOAC Research Institute: PTM, OMA, ERV and TME Programs (1:30PM– 1:45PM) Scott Coates, AOAC INTERNATIONAL

V. REPORT FROM THE PRODUCT CENTRIC WORKING GROUP (1:45PM – 2:45PM) Holly Johnson, AHPA & Julie Kowalski, Kowalski Science Support

VI. REPORT FROM THE PROFICIENCY TESTING WORKING GROUP (2:45PM – 3:00PM) Walter Brent Wilson, NIST

VII. REPORT FROM THE MICROBIAL CONTAMINANTS WORKING GROUP (3:15PM – 3:45PM) Julia Bramante, Colorado Department of Public Health & Environment

VIII. REPORT FROM THE TRAINING & EDUCATION WORKING GROUP (3:45PM – 4:00PM) Toby Astill, PerkinElmer

IX. PRESENTATION FROM NATIONAL SAFETY COUNCIL (4:00PM – 4:30PM) Katie Mueller, National Safety Council

X. DISCUSSION ON ADVISORY PANEL PRIORITIES (4:30PM – 5:00PM) Scott Coates will moderate a panel composed of experts in the field of Cannabis analytical science including CASP Science Advisor Susan Audino and CASP Advisory Panel Members . This will be an opportunity to provide input directly to the CASP Advisory Panel.

XI. ADJOURN (5:00PM)

Palmer Orlandi, AOAC INTERNATIONAL

06/15/2021 Version 2 – Subject to Change Without Notice

Break at 3:00PM

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CASP 2021 and Beyond

Christopher Dent Manager, Standards and Methods CASP Program Lead AOAC INTERNATIONAL

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CASP as an Integrated Program

AOAC Research Institute / ERV

Training and Education

Marketing and Comms

Standards and OMA

Proficiency Testing

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Slide 1 CD1 Christopher Dent, 4/23/2021

CASP Advisory Panel

CASP Community

Microbial Contaminants Working Group Microbiology Working Group

Cannabinoids Working Group

Proficiency Testing Working Group

Product Centric Working Group

Training and Education Working Group

Chemical Contaminants Working Group

AOAC Staff & CASP Science Advisor

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CASP Community • This is YOU! • All are invited to semi ‐ annual in person CASP meetings. • Consists of all members of the working groups, advisory panel and anyone who has signed up for the CASP mailing list. • It’s how we communicate our offerings to the community AND where we source our experts for the various working groups, ERPs, training sessions, etc. If you want to join ONLY the CASP Community, visit http://tinyurl.com/CASPAOAC and select “mailing list only” OR the working group(s) you would like to join.

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CASP Advisory Panel • Determines the priorities and direction of the program • Members join at an organizational level • Meet generally quarterly to review program progress and when needed discuss topics • Different levels of membership (Pioneer, partner, affiliate)

If you would like to become a member of the AOAC CASP Advisory Panel, contact Alicia Meiklejohn by email at ameiklejohn@aoac.org or call (301) 924 ‐ 7077 x 101 to discuss.

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PIONEER:

6 ‐ CEM Corporation ‐ Institute of Food Technologies ‐ Bio ‐ Rad ‐ Canopy Growth Corporation ‐ ABC Testing ‐ Association of Food and Drug Officials ‐ Deibel Biosciene ‐ Industrial Labs PARTNER: ‐ Eurofins Scientific ‐ Horiba Scientific AFFILIATE:

‐ Ionization Labs ‐ Materia Medica ‐ Millipore Sigma ‐ PerkinElmer ‐ S ō RSE Technology ‐ TEQ Laboratories

‐ Medicinal Genomics ‐ Q Laboratories

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Interested in Being a CASP Advisory Panel Member?

• There are four levels of CASP annual membership: Pioneer , Partner, Affiliate, and now, Government • All levels offer participation on the CASP Advisory Panel, which meets quarterly to review progress and rank priorities for the overall program • Other member benefits will vary by tier and may include: name and logo in AOAC communications and outreach, discounts on AOAC services, and access to standing groups of technical experts • Pioneers receive discounts on AOAC Consulting Services and use of the CASP Logo in your related communication underscoring your leadership in the AOAC CASP Program

Government Tier • Created to allow state labs access to the Advisory Panel

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Product Centric Working Group • Brand new group! • Merger of the Chemical Contaminants Working Group and the Cannabinoids Working Group • Co ‐ Chairs are Holly Johnson, AHPA and Julie Kowalski, Kowalski Science Solutions • Will focus on cannabinoid content and chemical contamination of finished products. NOT Micro. • Most of their work will lead to SMPRs, standards that methods need to meet to become OMAs via AOAC ERP review. • Could also be developing guidelines, other standard documents, whatever the community needs.

If you want to join any of our CASP working groups, visit http://tinyurl.com/CASPAOAC and select your desired groups.

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Microbiology Working Group • Chair is Julia Bramante of the Colorado Department of Public Health and Environment • Latest SMPR, Total Yeast and Mold , just completed public comment period.

• Chair will determine if the group needs to meet again for this SMPR based on the comments submitted. • If they don’t the group will move on to its next topic while the Yeast and Mold SMPR goes out to the CASP Community for a vote. • Next topics are under discussion by the CASP Advisory Panel and may be another SMPR but could also be validation guidelines for cannabis microbiology, a new appendix for the AOAC Official Methods of Analysis. • Most of this group’s work will lead to SMPRs, standards that methods need to meet to become OMAs via AOAC ERP review. If you want to join any of our CASP working groups, visit http://tinyurl.com/CASPAOAC and select your desired groups.

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SMPRs Developed SMPR 2017.001: Quantitation of Cannabinoids in Cannabis Concentrates SMPR 2017.002: Quantitation of Cannabinoids in Dried Plant Materials SMPR 2017.019: Quantitation of Cannabinoids in Edible Chocolate SMPR 2018.011: Identification and Quantitation of Selected Pesticide Residues in Dried Cannabis Materials SMPR 2019.001: Detection of Aspergillus in Cannabis and Cannabis Products SMPR 2019.002: Identification and Quantitation of Selected Residual Solvents in Cannabis Derived Materials SMPR 2019.003: Quantitation of Cannabinoids in Plant Materials of Hemp (low THC varieties of Cannabis) SMPR 2020.001: Determination of Heavy Metals in a Variety of Cannabis and Cannabis Derived Products SMPR 2020.012: Detection of Shiga Toxin Producing Escherichia coli in Cannabis and Cannabis Products SMPR 2020.013: Mycotoxin Screening Technique in Cannabis Plant Material and Derivatives

SMPR 2021.XXX: Total Yeast and Mold SMPR 2021.XXX: Quantitative Mycotoxins SMPR 2021.XXX: Cannabinoids in Cannabis Infused Beverages

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Training and Education Working Group • Chaired by Toby Astill, PerkinElmer. • First meeting led to not only recommendations for training but the actual development of a series of webinars, facilitated by the Chair and presented by various members of the group. • Webinars included: • Setting up a Cannabis Lab (330 Registrants) • Microbial Contaminants in Cannabis (307 Registrants) • Heavy Metals in Cannabis (271 Registrants) • Pesticides in Cannabis (340 Registrants) • Survey feedback showed a high level of satisfaction with these sessions. • Working group met again April 27 to discuss next steps, including an update from USDA on the Hemp Final Rule in June (more info soon).

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Proficiency Testing Working Group  Chair of PT Working Group (and Subgroups) o Dr. Brent (Walter) Wilson  Technical requirements for the following potential PT programs have been determined: o Cannabinoids o Pesticide Residues  Other Subgroups

o AOAC is determining a schedule for the remaining subgroups o Certain subgroups take priority based on WG feedback o Other Subgroups  Moisture/Aw ‐ this group has met once and will be scheduled to meet soon

 The technical recommendations will be provided to the Advisory Task Force for implementation

 Moisture/Aw (reporting would be a component of other PT program areas)

 Advisory Task Force has been formed  The Microbial Contaminants Subgroup met on 4 ‐ 30 ‐ 21 o The meeting was well attended, and members provided excellent feedback on technical recommendations

 Terpenes  Heavy Metals  Mycotoxins  Residual Solvents

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Would you like to join a subgroup? Contact Shane Flynn, Director of PT at CASP_PT_WG@aoac.org

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CASP Expert Review Panels • AOAC Conformity Assessment Process • Three ERPs: • Cannabinoids ERP, Chair: Melissa Phillips, NIST • Chemical Contaminants ERP, Chair: Andrew Pham, Epic Labs • Microbial Contaminants ERP, Chair: Julia Bramante, CDPHE Recent Meetings: April 28, 2021: Cannabinoids ERP, two methods approved August 3, 2021: Chemical Contaminants ERP, one method approved August 5, 2021: Microbial Contaminants ERP, two matrix extensions approved

• Variety of Potential Method Submissions • Pesticides • Residual Solvents

• Salmonella • Aspergillus • See them all at www.aoac.org

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CASP Methods Approved as of August 28, 2021 • AOAC OMA 2018.11 Quantitation of Cannabinoids in Cannabis Dried Plant Materials, Concentrates, and Oils • AOAC OMA 2018.10 Cannabinoids in Dried Flowers and Oil • AOAC OMA: Method for the Quantification of Cannabinoids in Edible Chocolate by High-Pressure Liquid Chromatography: Single Laboratory Validation • AOAC OMA: Quantitating Cannabinoids in Edible Chocolates Liquid Chromatographic Separation with Photodiode Array Detection • AOAC OMA: Determination of Heavy Metals in a Variety of Cannabis and Cannabis ‐ Derived Products • Matrix Extensions of OMA 997.02 and OMA 2002.11 for Total Yeast and Mold in Cannabis

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Open Calls for Methods

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Importance of this Work • 2018 Farm Bill directed USDA to establish a national regulatory framework for hemp production in the United States • Based on this, USDA published a final rule in January 2021, providing regulations for the production of hemp. AOAC is mentioned twice in final rule.

• State regulations for cannabis

• Not just important domestically – 3 out of 4 of our CASP OMAs are international

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2022 and Beyond New Working Groups?

• Adulteration Working Group? • Trade Issues Working Group? Training and Education • Continued integration with AOAC’s wider training and education efforts • Cannabis specific validation training courses • States needs Proficiency Testing • Continue to advise AOAC’s PT program • Possible new activities

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CASP as an Integrated Program • CASP is an integrated program encapsulating much more than standards development and impacting many different parts of the Cannabis industry and leveraging several different departments within AOAC (e.g. proficiency testing, training, standards development) • As long as CASP persists it will continue to address multiple integrated needs of the cannabis analytical science community.

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Are you an AOAC INTERNATIONAL Member? Learn more about membership at www.aoac.org

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2021 Advisory Panel

Pioneer Members

Millipore Sigma

Association of Food and Drug Officials (AFDO)

TEQ & Industrial Labs

PerkinElmer

Ionization Labs

ABC Testing/Materia Medica

S ō RSE Technology

Deibel Bioscience

Partner Members Horiba

Eurofins Scientific

Affiliate Level

CEM Corporation Institute of Food Technologists

Canopy Growth Corporation

Bio ‐ Rad

Q Laboratories

Medicinal Genomics

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Appreciation Special thanks to: • Dr. Susan Audino who serves as our Scientific Advisor. • Working group chairs who lead our volunteers. • All our volunteers who selflessly share their expertise. • The CASP Team at AOAC: • Scott Coates

• Dawn Frazier • Palmer Orlandi • Marida Hines • Jonathan Goodwin

• Deborah McKenzie • Alicia Meiklejohn • Arlene Fox • Shane Flynn

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Christopher Dent Manager for Standards and OMA & CASP Program Lead (301) 924 ‐ 7077 x 119 cdent@aoac.org

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