AOAC CASP Meeting - MYM 2020

56 57

4. Method Performance Requirements :

Limit of Quantitation (LOQ)

≤ 10 ppb (μg/kg)

Reproducibility (RSD R )

Repeatability (RSD r )

Range

Recovery

>100 ppb to 1 ppm ≥ 10 ppb to 100 ppb > 1 ppm to 10 ppm

15% 11% 7.3%

32% 16%

60% - 115% 80% - 115% 80% - 115%

8%

58 59 5. System suitability tests and/or analytical quality control: 60

61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91

Suitable methods will include blank check samples, and check standards at the

lowest point and midrange point of the analytical range.

6. Reference Material(s):

A certified reference material should be used when available. Internally produced reference materials may be used for a variety of cannabis products such as plant material, concentrates, and finished products until reference material is made available by an internationally-recognized organization such as Institute for Reference Materials and Measurements (IRMM) or United States National Institute of

Standards and Technology (NIST).

7. Validation Guidance & References :

Recommended level of validation: Official Methods of Analysis SM

USP <233>

8. Maximum Time-To-Result : No maximum time.

Table 1: Optional Elements Not Frequently Required

• Antimony • Barium • Chromium • Copper

CAS No. 744-36-0 CAS No. 744-39-3 CAS No. 18540-29-9 CAS No. 744-50-8 CAS No. 7440-02-0 CAS No. 7440-22-4 CAS No. 7782-49-2 CAS No. 7440-66-6

• Nickel • Silver

• Selenium

• Zinc