AOAC CASP Meeting

DRAFT AOAC SMPR 2018.XXX; Version 2, July 23, 2019 Version 4, September 6, 2019 1 2 Method Name: Identification and Quantitation of Selected Residual Solvents in Dried 3 Cannabis Materials 6 7 1. Purpose: AOAC SMPRs describe the minimum recommended performance characteristics to be used 8 during the evaluation of a method. The evaluation may be an on-site verification, a single-laboratory 9 validation, or a multi-site collaborative study. SMPRs are written and adopted by AOAC Stakeholder 10 Panels composed of representatives from the industry, regulatory organizations, contract 11 laboratories, test kit manufacturers, and academic institutions. AOAC SMPRs are used by AOAC Expert 12 Review Panels in their evaluation of validation study data for method being considered for 13 Performance Tested Methods or AOAC Official Methods of Analysis ,and can be used as acceptance 14 criteria for verification at user laboratories. 4 5 Intended Use : Consensus-based Reference method.

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2. Applicability :

Method, or a suite of methods, to identify and quantify selected residual solvents (Table 1) in

cannabis derivatives.

3. Analytical Technique :

Any analytical technique(s) that measures the analytes of interest and meets the following method performance requirements is/are acceptable. More than one analytical technique may be needed.

4. Definitions :

Cannabis Plant Material

Plant material from Cannabis sp. and its hybrids. Chemical varieties or “chemovars”

Cannabis Derivatives

Products or extracts derived from cannabis plant material.

Limit of Detection (LOD)

The minimum concentration or mass of analyte in a given matrix that can be detected. A minimum

3 to 1 signal to background noise ratio (S/N).

Limit of Quantitation (LOQ)

The minimum concentration or mass of analyte in a given matrix that can be reported as a quantitative result. A minimum 10 to 1 signal to background noise ratio (S/N).

Parts Per Million (PPM)

mg of analyte per kg of cannabis derivatives .

Quantitative method