AOAC CASP Meeting

Comments Submitted Quantitation of cannabinoids in plant materials of hemp  (low THC varieties Cannabis sp.) Comment or Concern  Proposed Change(s)

Comment that RSDr and RSDR may be  unrealistic, especially in reproducibility. Definitions: ‐ Include a definition for dry  weight basis  Line 20:  Recommendation to develop a  moisture method for cannabis

Possible definition for “Dry weight basis”:  Dry weight basis: Reported results are  mathematically corrected for the amount  of moisture present in the sample at the  time of weighing.  

Ranges (%)

Parameters*

0.05 – 0.5   

> 0.5 ‐ 5   

5 ‐ 35

Recovery (%)

85 – 118

90 ‐ 111

95‐105

% RSD r % RSD R

≤ 5

≤ 3

≤ 2

≤ 8

≤ 6

≤ 4

*All calculated on dry  weight basis; observed  values to be compared  to indicated limits for  accept bility.

Only applicable  to CBD and  CBDA

Mudge et al. Anal Bioanal Chem . 2017; 409(12): 3153–3163.