AOAC GFA Stakeholder Program Meeting Book (August 27, 2023)

Major Updates from Current Appendix M

• Guidance for both qualitative and quantitative methods • Reporting units in line with risk assessment work o mg total protein from the allergenic source/kg matrix • Requirement for incurred food matrices (in line with SMPRs) and guidance on preparation • More extensive recommendations for selectivity studies o Which foods should be analyzed for cross-reactivity and interference? • Requiring intermediate precision estimation in SLV, in addition to repeatability • Detailed instructions, R code, and examples of statistical analysis procedures