AOAC Method Validation (August 29, 2018)

False Positive/False Negative Rates/Sensitivity vs. Probability of Detection (POD)

Discussion

Clarification on Number of Calibration Points

Background X A method for measurement of 2-MCPD, 3-MCPD and glycidols was reviewed by the MCPD Expert Review Panel on March 14, 2018. The primary and secondary reviewers were satisfied that the method met the minimum performance requirements. X However, a reviewer mentioned that the method specifies only one calibration point. This observation started a discussion about the minimum number of calibration points that should be required in a method.