AOAC Midyear Meetng - Acrylamide WG

Sign in to access meeting materials

AOAC INTERNATIONAL Acrylamide Working Group

Midyear Meeting Thursday, March 17, 2022 1:00pm – 2:30pm ET Draft Agenda Moderators: Deborah McKenzie & Allison Baker (AOAC INTERNATIONAL)


WELCOME & INTRODUCTIONS (1:00pm – 1:10pm) Dr. Katerina Mastovska (Eurofins) and Dr. Aurélien Desmarchelier (Société des Produits Nestlé) will welcome attendees. A representative from AOAC will go through roll call. SMPR DEVELOPMENT (1:10pm – 2:20pm) Drs. Katerina Mastovska and Aurélien Desmarchelier will lead the working group to make changes and additions to the SMPR template based on priorities established by the project’s advisory panel as stated during the WG Launch.



NEXT STEPS AND LOOKING AHEAD (2:20pm – 2:30pm) A discussion of next steps for the working group



Items and times on this agenda are subject to change without notice.



AOAC INTERNATIONAL Policies and Procedures • AOAC INTERNATIONAL Policy on Antitrust • AOAC INTERNATIONAL Policy on Use of Association Name, Initials, Identifying Insignia, Letterhead and Business Cards • AOAC INTERNATIONAL Policy on Volunteer Conflict of Interest


AOAC DUE PROCESS FOR DEVELOPMENT OF NON ‐ METHOD CONSENSUS STANDARDS AND DOCUMENTS Policy for Due Process in the Development of AOAC Standards and Consensus Documents

AOAC INTERNATIONAL (AOAC) develops and publishes voluntary consensus standards and documents in support of method development, method modification, and method use or implementation. AOAC establishes voluntary consensus standards and documents in accordance to national and international principles for ensuring due process. AOAC’s consensus and standards development activities include participation from diverse perspectives across a given analytical industry or community area, discipline or issue. Standards are developed upon consensus of stakeholders. Approval of standards is based upon confirmation that the standard has been developed in accordance with AOAC’s processes 1 and principles, and as outline in Figure 1. Examples of AOAC consensus documents and standards include voluntary consensus standards; performance standards; methods of analysis; guidance documents; concepts of operation; best practice recommendation documents, and sampling approaches. POLICY STATEMENT AOAC develops national and international analytical non ‐ method consensus and standards documents according to the national and international principles for ensuring due process in the development of consensus documents and standards: openness, transparency, lack of dominance, balance, due consideration, coordination, consensus, and appeals. The AOAC Official Methods Board oversees the implementation of scientific and technical policies and procedures established by the AOAC Board of Directors including those for ensuring due process in establishing standards and consensus documents as outlined in Figure 1. The rules of engagement and parliamentary procedures for AOAC standards developing bodies follow Robert’s Rules of Order (latest edition) in accordance with AOAC bylaws and policies.

Figure 1 ‐ Overview Flow for Consensus & Standard Development

1 AOAC has documentation on the details of the processes used to develop its standards and consensus documents. These supporting documentation include terminology, process details in text with an accompanying flowchart, and a document stage handout.

Approved by AOAC Board of Directors on June 10, 2020.

Acrylamide Working Group AOAC Midyear Meeting 2022

Katerina Mastovska, Eurofins Scientific, US Food Division Aurélien Desmarchelier, Société des Produits Nestlé, Lausanne, Switzerland March 17, 2022

AOAC Acrylamide Working Group

November 1, 2021 - AOAC New Initiative on Acrylamide February 10, 2022 - Working group launch March 3, 2022 - Working group meeting 1 March 17, 2022 - Working group meeting 2 - Midyear meeting




Supporting tools and people • Co-chairs: and

• Coordinator of the working group: • Teams including WG Launch Presentation and SMPR

The focus on Acrylamide has never been so high

See release of CR 2017/2158 Benchmark levels and subsequent publications from 2018-2020

Source: – Keywords : Acrylamide + Food + Method

Literature profusion in 2018-20: A reflection of pending challenges for reliable Acrylamide determination?

Challenges: Risks of misquantification

P-test reports, Application Notes, Publications …. … │z - score│>2, some values obtained from reference standards

‘Isobaric interferences’, ‘Interference free determination’, ‘overestimation’

Case 1: Importance of Chromatographic Selectivity Chromatographic profile of m/z 72 → 55 in food extracts analyzed with acidified (method A a ) or neutral (method A n ) mobile phases. Retention time for acrylamide and N -acetyl- β -alanine are underlined. Method based on EN 16618:2015 standard

Discrepancies up to 40% in coffee in case of coelution

Extract Injected either with: Acidic (A a )or Neutral (A n ) mobile phases

Case 2: Selectivity of the Sample Preparation

Method based on FDA

Chromatographic profile of m/z 72 → 55 in a cocoa extract analyzed with Methods B and C.





Discrepancies up to x20 in cocoa in case of insufficient sample prep.

Different extent of clean-up

Considerations for the SMPR Development

Method Performance Requirements COMMISSION REGULATION (EU) 2017/2158 of 20 November 2017 establishing mitigation measures and benchmark levels for the reduction of the presence of acrylamide in food – ANNEX II (Analysis requirements)

EU Benchmark Levels


Derived LOQ requirements:

Wheat based soft bread Baby foods, processed cereal based foods for infants and young children excluding biscuits and rusks Soft bread other than wheat based bread

≤ 20 µg/kg

≤ 40 µg/kg ≤ 50 µg/kg

Other matrices

Note: Proposed benchmark level for cocoa powder: 450 µg/kg

California Proposition 65 Safe Drinking Water and Toxic Enforcement Act of 1986

Prop 65 requires businesses to provide warnings to Californians about significant exposures to chemicals that cause cancer, birth defects or other reproductive harm .

“Consuming this product can expose you to acrylamide, a probable human carcinogen formed in some foods during cooking or processing at high temperatures. Many factors affect your cancer risk, including the frequency and amount of the chemical consumed. For more information including ways to reduce your exposure, see”

≥ EU Benchmark level < EU Benchmark level

California 27 CCR § 25505 Food/Food groups

Max. average conc. level (ppb)

Max. unit conc. level (ppb)

Almonds, roasted and chocolate-covered almonds

225 100

--- --- ---

Bread, non-wheat-based products including loaves, rolls, buns, baguettes Bread, wheat-based products including loaves, rolls, buns, baguettes

50 75

Cookies, animal and animal crackers (sweet)

100 300

Cookies, thin and crispy Cookies, sandwich wafers

281 115 350 280 350 281 280


Crackers, savory, including crispbread Potato products, French fried potatoes

490 400 490

Potato or sweet potato products, not otherwise specified, such as hash browns and potato puffs

Potato or sweet potato products, sliced chips




South Korea – Recommended Specification

Commodity/Product Name

Recommended specification (µg/kg)

Baby foods for infants/young children

≤ 300 ≤ 300


Confectionery French fries

≤ 1000 ≤ 1000

Coffee (roasted coffee, instant coffee, coffee mix)

≤ 800

Teas (Solid tea)

≤ 1000 ≤ 1000

Processed cereal product and Ready-to-eat food

Proposed Fitness for Purpose

Quantitative analysis of acrylamide in potato products, bakery products, coffee, baby foods, cereal products, dry pet foods, cocoa products, nuts, tea and herbal extracts. Draft Applicability for SMPR Development

Version 2 (March 4, 2021) 1 2 Standard Method Performance Requirements (SMPRs) for Acrylamide in potato 3 products, bakery products, coffee, baby foods, cereal products, dry pet foods, cocoa 4 products, nuts, tea and herbal extracts. 5 6 Intended Use: Surveillance and Monitoring by Trained Technicians 7 8 1. Purpose 9 AOAC SMPRs describe the minimum recommended performance characteristics to be 10 used during the evaluation of a method. The evaluation may be an on-site verification, a 11 single-laboratory validation, or a multi-site collaborative study. SMPRs are written and 12 adopted by AOAC stakeholder panels composed of representatives from the industry, 13 regulatory organizations, contract laboratories, test kit manufacturers, and academic 14 institutions. AOAC SMPRs are used by AOAC expert review panels in their evaluation of 15 validation study data for method being considered for Performance Tested Methods SM or 16 AOAC Official Methods of Analysis SM and can be used as acceptance criteria for 17 verification at user laboratories. 18 2. Applicability 19 Quantitative analysis of acrylamide in potato products, bakery products, coffee 20 (roasted and instant), baby foods (cereal based – including biscuits and rusks), cereal 21 products, dry pet foods, cocoa products, tea and herbal extracts. 22 3. Analytical Technique 23 Chromatographic separation with mass spectrometric detection. 24 4. Definitions 25 Limit of quantitation (LOQ) .—LOQ is the lowest level of analyte in a test sample that can 26 be quantified at a specified level of precision. 27 Repeatability . —Variation arising when all efforts are made to keep conditions constant 28 by using the same instrument and operator (in the same laboratory) and repeating 29 during a short time period. Expressed as the repeatability standard deviation (SDr); or 30 % repeatability relative standard deviation (%RSDr). 3 3 1 2 Reproducibility .—Variation arising when identical test materials are analyzed in different 33 laboratory by different operators on different instruments. The standard deviation or 34 relative standard deviation calculated from among-laboratory data. Expressed as the 35 reproducibility standard deviation (SDR); or % reproducibility relative standard deviation 36

(% RSDR). 3 3 7 8 Recovery .—The fraction or percentage of analyte that is measured when the test sample 39 is analyzed using the entire method. 4 4 0 1 Selectivity .—The ability of the extraction, the clean-up, the separation system and 42 (especially) the detector to discriminate between the analyte and other compounds. 4 4 3 4 5. Method Performance Requirements 4 4 5 6 Table 1. Limit of quantitation (LOQ) 47 Food Targeted LOQ (µg/kg) Soft bread ≤ 20

Baby foods, processed cereal based foods for infants and young children excluding biscuits and rusks

Other matrices 48 Table 2. Recovery, repeatability and reproducibility parameters 49 Parameter Criterion Recovery, % 75 -110 RSDr, % ≤ 50

0.66 times RSDR as derived from (modified) Horwitz equation a

RSDR, % As derived from (modified) Horwitz equation a a Horwitz equation for predicted relative standard deviation of reproducibility: PRSD R = 2C - 0.15 , 50 where C is analyte concentration expressed as mass fraction. 5 5 1 2 6. System Suitability Tests and/or Analytical Quality Control 53 Suitable methods will include analysis of blanks and appropriate check standards. 54 Solvent blanks should be below the limit of detection (LOD = 0.3 x LOQ). Whenever 55 possible, quality control/reference materials should be included too ( see part 7 ). 56 7. Reference materials 5 5 7 8 A non-exhaustive list of Reference- and Quality Control-Materials for acrylamide are 59 available from: 60 (a) FAPAS (Sand Hutton, York, United Kingdom): French fries (Pre-cooked) ( TYG085RM , 61 reference value = 71 µg/kg); biscuit (cookie) ( T30104QC , 205 µg/kg); vegetable crisps 62 ( T30101QC , 1105 µg/kg); infant foodstuffs (biscuit for infants) ( T3092QC , 164 µg/kg); 63 infant food ( T30102QC , 196 µg/kg); instant coffees ( T3087QC , 613 µg/kg and T30107QC , 64 561 µg/kg); Potato crisps ( T30109 , 718 µg/kg); and 65

(b) BAM (Berlin, Germany): crispbread ( ERM-BD272 , 980 µg/kg), toasted bread ( ERM- 66 BD273 , 425 µg/kg), rusk ( ERM-BD273 , 74 µg/kg). 67 Refer to Annex F: Development and Use of In-House Reference Materials in Appendix F: 68 Guidelines for Standard Method Performance Requirements , 19 th Edition of the AOAC 69 INTERNATIONAL Official Methods of Analysis (2012). Available at: 70 7 7 1 2 8. Validation Guidance 73 For matrices with low levels of acrylamide, validation should be conducted at the 74 target LOQ and 5 xLOQ levels. The LOQ is determined as the lowest spiking level that 75 meets the recovery and repeatability requirements. Suitable matrix ‘blanks’ should be 76 selected that do not contain more than 30% of the target LOQ level. 77 For matrices that naturally contain higher levels of acrylamide and where suitable 78 matrix blanks (with ac rylamide concentration ≤ 30% of the target LOQ) are not available, 79 the matrix should be analyzed as such and spiked at least at one concentration level in 80 the range of 3- 5 x the acrylamide level in the evaluated matrix. In this case, the LOQ can 81 be estimated based on extrapolation of signal-to-noise ratio (S/N) obtained for a 82 concentration level naturally present in the evaluated matrix to a concentration level that 83 would correspond to S/N = 10. 84 Selectivity of the method should be evaluated to demonstrate that known 85 interferences, including N -acetyl- β -alanine, lactamide, and 3-aminopropanamide, do not 86 co-elute with acrylamide peak. Baseline separation of the acrylamide peak and peaks of 87 these compounds should be achieved and/or it should be demonstrated that these 88 interferences are removed prior to the chromatographic separation (during extraction 89 and/or clean-up steps). 90 When available, the use of Reference- and Quality Control-Materials is recommended. 91 For MS identification criteria refer to Part D in SANTE/11312/2021 guidelines 92 (pesticides_mrl_guidelines_wrkdoc_2021-11312.pdf ( 93 Appendix F: Guidelines for Standard Method Performance Requirements , Official 94 Methods of Analysis of AOAC INTERNATIONAL (2016) 20th Ed., AOAC INTERNATIONAL, 95 Rockville, MD, USA (http://www. 96 9. Maximum Time-to-Results 97 None. 1 9 9 0 8 9 0 101

Table 3: Acrylamide, internal standard(s) and compounds to assess for chromatographic 102 selectivity 1 1 0 0 3 4 Common Name CAS Number Molecular Structure



d 3 -Acrylamide 13 C 3 -Acrylamide 13 C 3 ,d 3 -Acrylamide

122775 -19-3 287399-26-2 2319788-93- 5


N -Acetyl-ß-alanine

3025 - 95 -4


4726- 85 -6



1 1 0 0 5 6

Table 4. Target matrices* 1 1 0 0 7 8 Matrix category

Typical representatives

Potato products

French fries Crisps (chips)

Cereal & Bakery products** including processed cereal-based baby food

Processed cereals-based foods, biscuits and rusks intended for infants and young children Breakfast cereals Bread Crispbread, cookies, biscuits, wafers, crackers, snacks (e.g., popcorn, pretzels) Cocoa powder, dark chocolate, milk chocolate, baking chocolate

Cocoa products


Roasted coffee Instant coffee


Instant tea, including green tea, black tea, herbal tea, oolong tea Botanical powdered extract (e.g., ginger powder)

Herbal extracts


Roasted almonds, hazelnuts

Petfood Dry dog or dry cat pet food (e.g., kibbles) *Validation has to be conducted on at least one representative from the listed matrix categories. 109 **For the ‘Cereal and Bakery product’ category including Infant cereals and Bread with low LOQ 110 requirement at ≤ 20 µg/kg, any selected representative matrix should meet the LOQ ≤ 20 µg/kg criteria. 1 1 1 1 1 2

AOAC Working Group Orientation

AOAC Working Group on Acrylamide Launch Meeting 10 February 2022 Deborah McKenzie Standards and Official Methods SM AOAC INTERNATIONAL

Orientation Agenda

AOAC Working Group Goals & Overview

AOAC Standards Development

Standard Method Performance Requirements

Working Responsibilities & Operation

Goals of AOAC Working Group on Acrylamide (WGA)

An integrated science project for acrylamide to develop voluntary consensus standards for the determination of acrylamide to address analytical method gaps for food matrices.

• Potato products, bakery products, coffee (roast, grounds, instant), baby foods (cereal based – including biscuits), dry pet foods,cocoa, and teas and extracts. SMPR Matrices: • Background on Acrylamide • Regulatory landscape including regulatory requirements for all these food products and definitions what needs to be regulated and the category of food to be regulated with a defined model • Analytical challenges with current approaches • Recommendation of a fitness for purpose statement (draft applicability statement) Considerations to include:

Working Group Launch

10 February 2022

How Does AOAC Develop Standards?

A concerted standards development process

Adherence to Standards Principles

Leverage global membership, partnerships and body of science to form collaboration consensus volunteer bodies

Scientific and Performance Based

Integrated Science Programs Individual ASF affiliated Working Groups

Forms Working Groups as needed

The “Idea Incubator” Outreach and Collaborative Horizon Scanning

Program Development Propose Evaluate Prioritize Implement Program & WG Project Activities

Integrated Science Programs & ASF Working Groups

Core Science Programs •Departments or Divisions of AOAC that serve as the foundation for the science programs at AOAC. Each offers services as individual fee based programs and are incorporated into the integrated programs and projects to achieve the specific deliverables. •Standards & Official Methods SM •AOAC Research Institute •Laboratory Proficiency Testing Program

Integrated Science Programs •Ongoing deliverables; Incorporate >2 AOAC Core Science Programs & Services •Stakeholder Program on Agent Detection Assays (SPADA) •Stakeholder Program on Infant Formula & Adult Nutritionals (SPIFAN) Cannabis Analytical Science Program (CASP) •Food Authenticity and Fraud Program (FAM) •Gluten and Food Allergens Program (GFA) •Analytical International Methods and Standards Program (AIMS) (Launching) •Botanical and Dietary Supplement Product Integrity Program (New-Forthcoming)

Integrated Science Projects

•Single project or limited deliverable(s); Incorporation 1-2 AOAC Core Science Programs & Services •ASF WGs may transition into integrated science programs

•WG on Folic Acid •WG on Acrylamide

Orientation Agenda

AOAC Working Group Goals & Overview

AOAC Standards Development

Standard Method Performance Requirements

Working Responsibilities & Operation

Standards and Consensus Products

Integrating AOAC Consensus Products • Performance Requirements • Guidelines

Basic Principles • Transparency • Openness • Balance of Interests • Due Process • Consensus • Appeals

• Sampling Standards • Methods of Analysis • Best Practices • Operational Documents • Reference Materials • Training

Program or Project Stakeholders

• All stakeholders are entitled to due process. • All stakeholders can share their perspectives • Anyone with a material interest may participate • Standards are established by a group that lacks dominance by any one interest - BALANCE

Stakeholder Panel Composition

Perspective 1

Perspective 2

Perspective 3

• Draft standard must contain input of stakeholders of varying perspectives.

Perspective 6

Perspective 4

• AOAC will confirm consensus regardless of mechanism used to demonstrates consensus of the stakeholders.

Perspective 5

Very Basic AOAC Process

• ASF Emerging Challenge/Technology • Individual/Sole Source New Program/Project Formed

• Advisory Panel formed by program/project sponsors • Working Group Chairs and Science Advisor(s) assigned as needed Program/Project Scope Defined for Period of Time • Working Group draft standards • Draft standards receive input from all interests until consensus is achieved Standards Developed

Basic AOAC Standards Development Activity Framework

Works with AOAC to define scope of work to be launched, including development of new programs and/or new working groups (WGs) Advisory Panel Meeting

WG begin work and draft consensus documents via web conference and reach general consensus on draft standard between AOAC meetings WG Meetings

WG chair(s) present final draft standard along with reconciled comments for deliberation and consensus. Community Consensus

At AOAC meetings, launch WG effort by refining a preset scope of work into a basic applicability statement from which the WG to began drafting the standard (e.g., SMPR, guidelines, etc) Launching New WG Activities

Draft standard is posted for public comments. Comment period is ≥ 30 days Virtual public comment session via webconference Draft Standard Public Comment Period

Approval of Standard follows consideration of all input and with oversight by Official Methods Board (OMB). Publication of Standard is in the OMA Approval/Publication of Standard

Public Comments

Post “Call for Comments” to general public 01

Reconcile Comments 02

Facilitate online public forum 03

Orientation Agenda

AOAC Working Group Goals & Overview

AOAC Standards Development

Standard Method Performance Requirements

Working Responsibilities & Operation

• Each SMPR is identified by a unique SMPR-number consisting of the year followed by a sequential identification number (YYYY.XXX).

SMPR Format

SMPR Format

Intended use Purpose (Read Only Information) Applicability Analytical technique Definitions

SMPR Format






Performance requirements parameters for quantitative methods:

• Analytical range

• Limit of detection

• Limit of Quantitation • • Repeatability

• Recovery

• Reproducibility

SMPRs can be developed for all sorts of methods…

Quantitative methods Trace components Main components

Qualitative methods Trace components Main components

Identification methods

• SMPRs are published in the OMA and on the AOAC website

• SMPR ID numbers use the year and 3 numerals.

• OMA ID numbers use the year and 2 numerals.

OMA, Appendix F: Guideline to SMPRs

• Complete guidance designed to contain all of AOAC’s validation requirements. • Everything you need to develop an SMPR • Published in OMA

SMPR Guidelines – OMA, Appendix F Covers







SMPR Guidelines

Introduction SMPRs Annex A: SMPR Format

• Table A1: Performance Requirements • Table A2: Recommended Definitions • Table A3: Recommendations for Evaluation • Table A4: Annex 5: Expected Precision • Table A5: Expected Recovery • Table A6: Predicted Relative Standard Deviation of Reproducibility • Table A7: POD and Number of Test Portions

SMPR Guideline Annexes

Annex D: Definitions and Calculations of HorRat Values from intra- laboratory Data

Annex B: Classification of Methods

Annex C: Understanding the POD Model

Annex F: Development and Use of In-House Reference Materials

Annex E: AOAC Method Accuracy Review

Example SMPR®

Method Performance Parameters

Intended Use

Applicability Statement

Analytical Technique

System Suitability


Reference materials

Validation guidance

Time to Result

How are SMPRs Used?







Orientation Agenda

AOAC Working Group Goals & Overview

AOAC Standards Development

Standard Method Performance Requirements

Working Responsibilities & Operation

Working Group Responsibilities

 Working group members will be responsible to: o Active Participation • Participate and be prepared for WG meetings • Be willing to lead or participate in subgroups • Engage in online collaboration • Assist WG chairs in moving work forward • Follow AOAC processes and procedures

 Working group chairs will be responsible to: o Launch the working group activities • Review Relevant AOAC and Program Information • Develop Launch presentation • Provide presentation of final product • Lead reconciliation of comments • Moderate WG meetings • Provide summaries and track documentation updates • Follow AOAC processes and procedures

Training/Education Webinars

Additional Duties

Assistance to Method Authors

Provide guidance to methods in use

Identify experts

Tentative Timelines

PREPARE WORKING GROUP PRESENTATIONS - Launch Presentations AOAC Outreach and notification of new AOAC acrylamide standards activities AOAC Calls for Working Group Members

COMMENT RECONCILIATION & finalize SMRP draft AOAC Community Consensus – Draft SMPR Presentations

WORKING GROUP MEETINGS – Draft Standard (SMPR) Development

AOAC issues Call for Experts & Call for Methods

Jan.–Feb. 2022

Jun.-Jul 2022

Sep.-Oct 2022

Dec. 2021–Jan. 2022

Mar.–Jun. 2022

Jul.-Aug. 2022

Sep.-Oct. 2022

PUBLIC COMMENT PERIOD – written and online



• AOAC SMPR 2019.004 – Furan and Alkyl Furans in Coffee, Baby Foods, Infant Formula, Cereals, and Fruit Juices • Official Methods of Analysis , Appendix F: Guidelines for Standard Method Performance Requirements • AOAC Core Programs and Services

Resources for Working Groups

• Standards & Official Methods, Reviewed & Recognized, and Performance Tested Methods programs

• Community Email Blasts • Program updates, upcoming meetings, related activities, announcements, etc… • Your expertise, leadership, and volunteer service • Volunteer expertise of working group members

Working Group Collaboration

• Outside of scheduled WG meetings • MS SharePoint Site • MS Teams

• Scheduled WG meetings

Working Group People Resources


AOAC Staff Palmer Orlandi, Chief Science Officer and Deputy Executive Director Deborah McKenzie, Sr. Director, AOAC Science Programs (Standards and Official Methods SM ) Allison Baker, Coordinator, AOAC Science Programs (Standards and Official Methods SM )

WG Co-Chairs • Katerina Mastovska

• Aurélien Desmarchelier • Working Group Members

Tips for Successful Working Group Outcomes

Be cooperative and respectful of WG chair and WG colleagues

Be active and willing to participate and collaborate

Be prepared for WG meetings

If you know of expertise that should be included in the WG, please alert the WG chair and staff.

Alert staff should you have any questions

Welcome to the AOAC INTERNATIONAL 2022 Midyear Meeting! Thank you to our sponsors:

In Food & Agriculture, We Set the Standard

 Save money on publications, events, and education  Free access to the Journal of AOAC INTERNATIONAL and Inside Laboratory Management magazine  18 Regional Sections worldwide  2 Technical Divisions  2,300+ individual members  Lab managers, analytical chemists, microbiologists, food scientists, and more  85+ organizational members  Businesses, gov agencies, academic institutions



In Food & Agriculture, We Set the Standard

Organizational Membership: organizational-membership/ Individual Membership: individual-membership/


AOAC Membership Team: +1 (301) 924-7077 ext. 170

In Food & Agriculture, We Set the Standard

In Food & Agriculture, We Set the Standard

 AOAC’s premier program for developing food testing analytical science methods that are recognized and legally defensible worldwide  Evaluates methods across AOAC’s integrated science programs for adoption as First Action or Final Action Official Methods  Approved methods are published in the Official Methods of Analysis publication


In Food & Agriculture, We Set the Standard

Standards Developed/In Progress

 Biothreat agents  Botanicals & dietary supplements  Cannabis & hemp  Endocrine disruptors  Food authenticity

 Food allergens and glutens  Heat generated toxicants  Infant formula & adult Nutritionals  Foodborne pathogens  Veterinary drug residues


Global Standards Engagement

 Observer status in CODEX Alimentarius  Active member of the Interagency Meeting  Liaison agreement with ISO/TC 34

 Liaison arrangement with International Dairy Federation  ANSI-accredited US TAG to ISO/TC 34 (Food products)  MOU and joint participation with IAFNS  MOU with ARSO

In Food & Agriculture, We Set the Standard

 Helps labs compete in the global marketplace by demonstrating that they meet standards for accuracy, reliability, and compliance  A2LA-accredited program  Offers programs in microbiology, listeria, salmonella in liquid egg, food chemistry, pesticide residues, and more

In Food & Agriculture, We Set the Standard

NEW IN 2022: Cannabis and Hemp Proficiency Testing Program First Round: November 2022 To Enroll or for more information, contact AOAC PT Staff

In Food & Agriculture, We Set the Standard

 New program from the AOAC Research Institute  Certifies performance claims of application notes, user guides, or laboratory developed methods  Based on the same science required by the Performance Tested Methods (PTM) and Official Methods programs ptm/reviewed-and-recognized-program

In Food & Agriculture, We Set the Standard

 AOAC Research Institute program  Provides independent third-party review and certification for proprietary test method performance  Helps companies and their customers safeguard their businesses, mitigate risk, and protect consumers


In Food & Agriculture, We Set the Standard

Meeting attendees save 33% on the 21 st edition of the Official Methods of Analysis of AOAC INTERNATIONAL !  Use promo code 33OFFOMA

In Food & Agriculture, We Set the Standard

Get involved with the Journal of AOAC INTERNATIONAL! Seeking volunteers for:  Editor-in-Chief  Drug Formulations Section Editor  Statistical Analysis and Chemometrics Section Editor

In Food & Agriculture, We Set the Standard

 Food Authenticity Methods  Infant Formula  Marine and Freshwater Toxins  Metals  Microbiology  Mycotoxins  Pesticides  Vet Drug Residues  Water and Wastewater

 Agricultural Materials  Biothreat Agents  Cannabis and Hemp  Color Additives  Dietary Supplements and Botanicals  Environmental, Industrial, and Emerging Contaminants  Food Additive Safety  Food Allergens


In Food & Agriculture, We Set the Standard

 Analytical International Methods and Standards Program (launching during the MYM!)  Working group to develop voluntary consensus standards for the determination of pyrrolizidine alkaloids in teas, herbal infusions, herbs, seed spices and botanical dietary supplement ingredients  Working group to develop voluntary consensus standards for color additives from natural sources

NEW INITIATIVES AT AOAC – WE NEED YOUR SUPPORT! solutions/new-initiatives/

In Food & Agriculture, We Set the Standard


In Food & Agriculture, We Set the Standard

COMING SOON: AOAC’S New Botanical & Dietary Supplement Integrity Program!

Visit to learn about the program’s first working group to develop standards for folic acid in chewable gels, soft gels, and tablets.

In Food & Agriculture, We Set the Standard



Forms the AOAC Acrylamide Working Group Advisory Panel which advises on program direction and priorities

In Food & Agriculture, We Set the Standard

Made with FlippingBook PDF to HTML5