AOAC OMB Meeting Book 2-10-16

AOAC OMB Meeting

CHECKLIST FOR FINAL ACTION METHOD RECOMMENDATION

AOAC 2012.25

Residues of Three Triphenylmethane Dyes and Their Metabolites (Malachite Green, Leuco Malachite Green, Crystal Violet, and Brilliant Green) in Aquaculture Products Liquid Chromatography/Tandem Mass Spectrometry

OMB GUIDANCE FOR AOAC ERPS

Considered? Comments

Method Applicability

Yes

Triphenylmethane dyes as specified in applicability statement.

Safety Concerns Reference Materials

Yes Yes

Currently no reference materials available for these types of drugs Hurtaud-Pessel et al., J. AOAC Int . 96 , 1152(2013) Andersen et al., J. AOAC Int . 98 , 636(2015) – modification – matrix extension Schneider & Andersen J. AOAC Int . 98 , 658(2015) SMPR 2009.001 – SMPR for Quantitative Methods for Drug Residues in Shrimp, Tilapia, Catfish, and Salmon

Single Laboratory Validation

Yes

Reproducibility/Uncertainty and Probability of Detection

Yes

Comparison to SMPR

No

Feedback from Users of Method

Yes

Discussed in ERP Meeting

DOCUMENTATION Safety Evaluation Reference Materials

Available?

Comments

Yes No Yes

Completed; Discussed in ERP meeting None specified in SMPR; none available

Hurtaud-Pessel et al., J. AOAC Int . 96 , 1152(2013) Andersen et al., J. AOAC Int . 98 , 636(2015) Used SMPR; OMA appendix D, and help from Chemical Contaminants Community subgroup

SLV or PTMs

Approved Validation Protocols

No

Statistics Review

Yes Yes No

Completed

Method Published in OMA

2012.25

Method Performance vs SMPR criteria

SMPR 2009.001 – SMPR for Quantitative Methods for Drug Residues in Shrimp, Tilapia, Catfish, and Salmon

Feedback Information Additional Recognition(s)

Yes No Yes Yes

Discussed in ERP meeting

ERP Reports

10/2012; 12/2015

Hurtaud-Pessel et al., J. AOAC Int . 96 , 1152(2013) Andersen et al., J. AOAC Int . 98 , 636(2015) Schneider & Andersen J. AOAC Int . 98 , 658(2015) Method scope expanded and the latest version of the method approved by ERP is in Collaborative Study Manuscript published in 2015 by Schneider and Andersen.

Manuscript(s) Published in JAOAC

Method Recommended for Final Action

Yes

February 10-11, 2016

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