AOAC RI ERP Final Action Recommendations eBook

Dupont BAX Salmonella PTM Report Modification Approved 2012 / PTM Certification No. 081201 For Expert Review Panel Use Only Do Not Distribute

5

0.25

0.11-0.47

5

0.25

0.11-0.47

0

(-0.26, 0.26)

Dry pet food

BPW

0.29 (0.13, 0.53)

20

0

0

0-0.43

0

0

0-0.43

0

(-0.43, 0.43)

Unpaired

0.00

5

5

0.25

0.11-0.47

5

0.25

0.11-0.47

0

(-0.26, 0.26)

Dry pet food

LB

0.29 (0.13, 0.53)

20

Paired (-0.43, 0.43) a Note: For all sample matrices, the BAX® System method was evaluated using both the reference and an alternate test method enrichment in order to validate multiple 361 enrichment media for each sample type. 362 b N = Number of test potions 363 c x = Number of positive test portions 364 d POD C = Candidate method presumptive positive and culture confirmed outcomes divided by the total number of trials 365 e dPOD CP = Difference between the candidate method presumptive result and candidate method confirmed result POD values 366 f 95% CI = If the confidence interval of a dPOD does not contain zero, then the difference is statistically significant at the 5% level. 367 “If all results agree in a paired study, the measure of effect dPOD is zero, and the best estimate of s(dPod) = 0, so the t-based interval computes to zero as well. 368 To get a non-zero confidence interval … some other method must be used. For this special case of n pairs all agreeing, you can use a binomial-based 95% 369 confidence interval of +/- [1 - (0.05)^(1/n)] n = # pairs.” [6] 370 0.00 5 0 0 0-0.43 0 0 0-0.43 0

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