AOAC SPADA Meeting

Genomic diversity and assay design

Unexpected diversity within an  assay target • Variants within critical assay regions can  significantly impact performance • 1 variant had slight impact on EBOV detection • 2 variants had ~2 log impact

United States Army Medical Research Institute of Infectious Diseases Biodefense solutions to protect our nation

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High diversity: Lassa virus

Josiah Liberia Guinea Togo Pinneo Weller Nigeria

United States Army Medical Research Institute of Infectious Diseases Biodefense solutions to protect our nation 6