AOAC SPADA Meeting

Lesson from Genome Sequencing Standards • Genomics Standards Consortium • MIGS • Minimum Information about a Genome Sequence- captures information about a genome sequence- e.g., depth and breadth of coverage, sequencer type, organism information etc (Chain et al: Science 2009 326 (5950:236-237); Ladner et al. Mbio 2014 Jun 17;5(3):e01360-14) • MIMS • Minimum Information about a Metagenomic Sequence/Sample; metadata on samples and sequences (Kottmann et 1l 2008. OMICS 12 (2):115-121). • Why not a standard for microbial strains? • MIBS • Minimum Information about a Bacterial Strain. What are the information to be captured? • MIVS (not the focus now) • Minimum Information about a Viral Strain. What are the information to be captured?

2018_10_17_SPADA_Brief

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The impetus for this work (DoD specific) • May 2015 DPG debacle; In its aftermath, many committees were established and investigations were carried out to understand and fix DPG like problems. • Moratorium on Select agent work within DoD; Sec Army Directive to fortify safety of BAST activities within DoD and implementation of recommendations. Establishment of BBPO (BSAT Bio Safety Program Office). • Prevent indiscriminate transfer of iBSATs or dBSATS (derivative) that are not 100% guaranteed for inactivation. • Uncertainty of 100% guarantee of iBSATs safety and security • Need for materials BSAT derivatives across the biodefense enterprise; however, DBPAO divested BSAT business. • But leadership wanted DBPAO involvement in assurance of and confidence in materials from other sources by other means across the enterprise. So, setting the standard for strains used in assay development, test and evaluation

2018_10_17_SPADA_Brief

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