AOAC SPADA Meeting

3/11/2020

Genotype ‐ Phenotype Correlation

Phenotypic susceptibility

NAL FIS CHL TET STR

Sequencing/ genotyping

GyrA (S83L)

sul2 floR tetA strA/strB

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Why might genomics fail to detect AMR?

• Resistance genes not expressed • Lack of knowledge of mechanisms

• Gene disruption • Epigenetic effects • Efflux pumps

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