AOAC SPADA Meeting

3/11/2020

Opportunities: the case of mcr ‐ 1 • Colistin resistance gene identified in late 2015 • FDA did rapid retrospective surveillance of this gene • Identified none in U.S. among 42,000 public sequences • Three weeks later it was identified in Denmark

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Artificial intelligence/machine learning • Can identify new resistance mechanisms, overcome database limitations

Training datasets (phenotypic, sequencing data)

Model

New sequencing data

Predicted phenotypes

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Nguyen et al. J Clin Microbiol. 2019 Jan 30;57(2).

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