AOAC SPIFAN Chlorates ERP Report (12-13-21)

AOAC SPIFAN CONTAMINANTS EXPERT REVIEW PANEL REPORT

CHLORATES/PERCHLORATES MARCH 30, 2022

AOAC SPIFANContaminants Expert Review Panel Report March 30, 2022 Version 1

AOAC INTERNATIONAL Stakeholder Program on Infant Formula and Adult Nutritionals (SPIFAN) Contaminants Expert Review Panel (ERP)

The AOAC SPIFAN Contaminants Expert Review Panel (ERP) Chair confirms the following ERP Report has been reviewed and approves the final version of the Official Chair’s Report for Chlorates/Perchlorates March 30, 2022

Katerina Mastovska (Apr 19, 2022 15:13 EDT) Katerina Mastovska

Signature

Apr 19, 2022

Date

AOAC SPIFANContaminants Expert Review Panel Report March 30, 2022 Version 1

AOAC INTERNATIONAL Stakeholder Program on Infant Formula and Adult Nutritionals (SPIFAN) “Virtually” Meeting at AOAC INTERNATIONAL 2275 Research Blvd. Suite 300, Rockville, MD, USA Wednesday, March 30, 2022 REPORT OF THE CONTAMINANTS EXPERT REVIEWPANEL (ERP) PROCEEDINGS

Expert Review Panel Members ( in attendance ):

Katerina Mastovska

Eurofins Scientific (Chair)

Jonathan Draher

Abbott Nutrition MetrohmUSA Nestlé Research

Jay Gandhi

José Fernando Huertas Pérez

Melissa Phillips

NIST

Tom Phillips

SCS MDA

Marina Torres Rodriguez

LATU

Expert Review Panel Members ( unable to attend ): Andrew Savage

Nestlé Quality Assurance Center

AOAC SPIFANContaminants Expert Review Panel Report March 30, 2022 Version 1

AOAC Staff Includes: Saliha Argubie Delia Boyd Deborah McKenzie Allison Baker

Observers: Soraya Bellini, CIATI Joe Boison, EJ Consultancy Esther Campos Gimenez, Société des Produits Nestlé S.A. Hans Cruijsen, FrieslandCampina Jennifer Glenn, Lisa Graham, AsureQuality Srinivas Jayanthi, DB Science LLC-NWA Habakuki Kalebo, Tanzania Bureau of Standards (TBS) Juliette Keyagye, Johannes Kron, Eurofins CLF Specialised Nutrition Testing Services GmbH Erik Konings, Société des Produits Nestlé S.A. Elsa Lotz, AsureQuality Adelle Nancekwell, AsureQuality Giampaolo Perinello, Mérieux NutriSciences (Italy) Darryl Sullivan, Eurofins US Liz Teigland, Agropur David Woollard, Massey University Jinchuan Yang, Waters Corp.

I. WELCOME AND INTRODUCTIONS KaterinaMastovska welcomed all participants to the ERP meeting and the ERP members were introduced.

II. REVIEWOF METHODS BY EXPERT REVIEW PANEL (ERP) FOR FIRST ACTION OFFICIAL METHOD SM STATUS For each method, the ERP reviewed and discussed method(s) submitted for First Action Official Method SM status.

Method Title

Reviewer(s)

Vote

Method

Comments

Chlorate-01 – Chlorate and Perchlorate in Baby Foods, Infant/ Adult Formulas and Their Ingredients

CHLORATE / PERCHLORATE

Marina Torres Rodriguez Melissa Phillips Jonathan Draher J. Fernando Huertas Pérez

Motion: Method was not recommended for First Action Official Methods SM status Motion: To accept the listed ERP requirements for method authors to complete for reconsideration of the method for First Action status

See requirements below

Melissa Phillips proposed & Jayesh Gandhi second

Unanimous

CHLORATE-01 ERP REQUIREMENTS:

1. LC-MS/MS • Improve method to eliminate the observed interference. • Update SANTE guidelines reference & requirements for ion ratios and retention times. • Include information about column lifetime (number of sample injections). • Ensure there are correct transitions in the manuscript.

2. Matrices for validation • Provide recovery & precision data for all representative matrices at the LOQ level (5 replicates). • Provide recovery & precision data at 10x LOQ level (5 replicates) for at least one matrix (selected from the minimum representative matrices) category or sub-category. • This validation data needs to be obtained using the final method conditions.

3. Specify the type of filter used.

4. Address any other outstanding requirements highlighted by the ERP in December 2021 & March 2022 (see reviewer comments).

5. Provide information about results calculated with calibration that is forced through zero & not forced through zero.

III. NEXT STEPS/FEEDBACK FROM EXPERT REVIEW PANEL Katerina Mastovska provided next steps including requirements and recommendations from the Expert Review Panel to stakeholders.