AOAC SPIFAN ERP Meeting Book-March 16, 2016
VitK-01 w/SLV FOR ERP USE ONLY DO NOT DISTRIBUTE
Silliker Chem, Res. Center Crete, IL – Validation of a LC-MS/MS Method for Vitamin K Analysis
Validation of A LC-MS/MS Method for Analysis of Vitamin K in I nfant Formula and Adult Nutritional Samples
Objective:
Develop and validate a LC-MS/MS method for quantitation of vitamin K in infant formula and adult nutritional samples
Analyte Scope:
Vitamin K1 cis and trans and total Vitramin K2-7 Vitramin K2-4 .
Matrix Scope:
Infant Formula Samples Adult Nutritional
SPIFAN Samples Used for the Method Validation in this study
Provided to Silliker by SPIFAN on 10/28/13 The listing and details regarding the samples provided in Table 1. Table 1: Details of the samples used in the method validation
Sample #
Sample Name
Lot#ID
Child Formula Powder Infant Elemental Powder
00411RF00 00402RF00 00415RF00 00407RF00
1 2 3 4
Adult Nutritional RTF, High Protein Adult Nutritional RTF, High Fat
SPIFAN Blank Milk Form
Infant Formula RTF, Milk Based
5
SRM 1849a
CLC10-b
6
Adult Nutritional Powder Milk Protein Based Infant Formula Powder Partially Hydrolyzed Milk based Infant Formula Powder Partially Hydrolyzed Soy Based Adult Nutritional Powder Low Fat
11750017V3
7
1172572116
8
117257651Z
9
00394RF00 00412RF00 00403RF00
10 11 12
Child Formula Powder Infant Elemental Powder
Silliker Laboratories, Chemistry Research Center, Date: 1/30/15
2
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