AOAC SPIFAN Nutrients ERP Report (July 26, 2022)

AOAC SPIFAN CONTAMINANTS EXPERT REVIEW PANEL REPORT

CHLORATES/PERCHLORATES JULY 26, 2022

AOAC INTERNATIONAL Stakeholder Program on Infant Formula and Adult Nutritionals (SPIFAN) Contaminants Expert Review Panel (ERP) The AOAC SPIFAN Contaminants Expert Review Panel (ERP) Chair confirms the following ERP Report has been reviewed and approves the final version of the Official Chair’s Report for Chlorates/Perchlorates July 26, 2022

Katerina Mastovska (Sep 5, 2022 16:15 EDT) Katerina Mastovska

Signature

Sep 5, 2022

Date

AOAC INTERNATIONAL Stakeholder Program on Infant Formula and Adult Nutritionals (SPIFAN) “Virtually” Meeting at AOAC INTERNATIONAL 2275 Research Blvd. Suite 300, Rockville, MD, USA Tuesday, July 26, 2022 REPORT OF THE CONTAMINANTS EXPERT REVIEWPANEL (ERP) PROCEEDINGS

Expert Review Panel Members ( in attendance ):

Katerina Mastovska

Eurofins Scientific (Chair)

Jonathan Draher

Abbott Nutrition MetrohmUSA Nestlé Research

Jay Gandhi

José Fernando Huertas Pérez

Melissa Phillips

NIST

Tom Phillips

SCS MDA

Marina Torres Rodriguez

LATU

Andrew Savage

Nestlé Quality Assurance Center

AOAC Staff Includes: Saliha Argubie Constance Bahr Allison Baker Delia Boyd Deborah McKenzie Alicia Meiklejohn Palmer Orlandi

I. WELCOME AND INTRODUCTIONS KaterinaMastovska welcomed all participants to the ERP meeting and the ERP members were introduced.

II. REVIEWOF METHODS BY EXPERT REVIEW PANEL (ERP) FOR FIRST ACTION OFFICIAL METHOD SM STATUS For each method, the ERP reviewed and discussed method(s) submitted for First Action Official Method SM status.

Method Title

Reviewer(s)

Vote

Method

Comments

CHLORATE / PERCHLORATE

Motion: To accept the ERP requirements for method authors to complete for reconsideration of the method for First Action Official Methods SM status Melissa Phillips proposed & Jayesh Gandhi second

Marina Torres Rodriguez Melissa Phillips J. Fernando Huertas Pérez

See requirements below

Chlorate-01 – Method for the Determination of Chlorate and Perchlorate in Baby Food, Baby Food Ingredients, Infant Formula and Infant Formula Ingredients by Liquid Chromatography – Tandem Mass Spectrometry: Single Laboratory Validation

Unanimous

CHLORATE-01 ERP REQUIREMENTS: 1. For infant formula provide additional example chromatograms at the LOQ level for different infant formula products 2. For meat and baby food, try to improve signal to noise at the target LOQ level 3. Provide RSDs and mean recoveries for each analyte, matrix and concentration level combination (see Excel table) 4. Determine LOQs according to the SMPR validation guidance at the lowest spiking level that meet the recovery and RSD requirements 5. For baby food provide validation data for each representative matrix separately (cereal based, fruit/vegetable based & meat based)

6. Label chromatograms with the actual spiking concentrations 7. Update the reference material codes in the manuscript

Motion: to accept these requirements/recommendations Melissa Phillips motioned & Jayesh Gandhi second

Method Title

Reviewer(s)

Vote

Method

Comments

CHLORATE / PERCHLORATE

Motion: to recommend Chlorate-02 to First Action Official Methods SM status with editorial changes 1 st Vote: 4 Yes/1 No/2 Abstain

See editorial requirements below

Chlorate-02 – A LC-MS/MS method for the sensitive and accurate quantification of Chlorate and Perchlorate in a broad range of food commodities, including baby food, nutritional formulas and ingredients thereof.

Tom Phillips Marina Torres- Rodriguez Jonathan Draher

2 nd Vote: 5 Yes/0 No/2 Abstain

CHLORATE-02 ERP REQUIREMENTS: 1. System suitability needs to be included as a separate section with clearly defined criteria

Motion: to accept these requirements/ recommendations Jonathan Draher motioned & Jayesh Gandhi second

III. NEXT STEPS/FEEDBACK FROM EXPERT REVIEW PANEL Katerina Mastovska provided next steps including requirements and recommendations from the Expert Review Panel to stakeholders.