AOAC SPIFAN Stakeholder Panel Meeting Book (September 7, 2019)
Interpersonal HMO variation Examples of factors influencing content and composition of HMO
• Presence / Absence of FUT2 • Presence / Absence of FUT3
Æ Secretor / non-secretor mothers (Se+ / Se-)
Æ Lewis positive / Lewis Negative (Le+ / Le-)
• Term / Preterm delivery
Æ Preterm higher HMO concentrations
• Lactation stage
Æ Colostrum higher in total & sialylated HMO
• Body Mass Index (BMI) • Parity
Æ Small but significant differences in HMO concentration and profile distribution 1
• Mode of Delivery
HMO composition is not identical and varies from mother to mother
1 Samuel et al. Nature Scientific Reports (2019) 9 : 11767
Beneficial health effects
• Prebiotics (growth of B. infantis, B. bifidum) • Antiadhesive properties (mimic natural ligands of bacteria; C. jejuni and 2’FL) • Epithelial Cell modulators (influencing cell surface glycosylation; reduce susceptibility for pathogens) • Leucocyte rolling & adhesion modulators (sialylated HMO interfere to P-selectin-mediated leucocyte adhesion during inflammation) • Brain development (breastfed infants higher bound Sia concentrations)
Bode (2012) Glycobiology 22, 1147-1162
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