AOAC SPIFAN Stakeholder Panel Meeting Book (September 7, 2019)

Fitness for Purpose statement

“An analytical method to determine the level of a number of selected HMOs in infant formula and adult nutritionals, as defined by AOAC SPIFAN. The method should be applicable for dispute resolution. Open point for discussion for Stakeholder Panel (and WG): do we want to have a method applicable for the determination of HMO in the raw material (ingredients) ?

if yes: within the same WG & same SMPR OR separate WG, separate SMPR ?

Questions for discussions within the WG

• List of analytes (selection of HMO)?

Æ 2’FL, 3FL, LNnT, LNT, 6’SL, 3’SL, DFL, (LNFP-I) ?

• Analytical range per HMO? • Selectivity / interferences

Æ based on FDA and EFSA approvals?

Æ lactose, FOS, GOS, non-HMO carbohydrates

• Availability of standards Æ limited availability of pure standards • Need of additional SMPR for standards (?) Æ to align analysis of standards and raw material