AOAC SPSFAM PAC ERP

II. Review of the Method Only 1. Does the applicability of the method support the applicability of the SMPR? If not, please explain what is missing.

No.

This method is able to determine A-type to B-type interflavan bonds in cranberry proanthocyanidins in cranberry fresh fruit powder, which is a matrix that was listed in Table 1 of SMPR. However, AOAC SMPR is seeking an identification method that can returns a binary, YES/NO test result about if cranberry Type-A proanthocyanidins present in an unknown sample. Validating the method based on the probability of identification model is a necessary step according to the AOAC validation guidance appendix K.

2. Does the analytical technique(s) used in the method meet the SMPR? If not, please specify how it differs from what is stated in the SMPR. 3. Are the definitions specified in the SMPR used and applied appropriately in the method? If no, please indicate how the terms are used. 4. Does the method, as written, contain all appropriate precautions and warnings related to the method's reagents, components, instrumentation, or method steps that may be hazardous? If no, please suggest wording or option(s). III. Review of Supporting Information 1. Are the definitions specified in the SMPR used and applied appropriately in the supporting documentation (manuscripts, method studies, etc...)? If not, please explain the differences and if the method is impacted by the difference.

Yes.

Yes.

No. This method doesn't contain safety information regarding handling reagents, components, and instrumentations.

III. Review of Information in Support of the Method

Yes.