AOAC SPSFAM PAC ERP

4. Based on the supporting information, is the method written clearly and concisely? If no, please specify the needed revisions. 5. Based on the supporting information, what are the pros/strengths of the method? 6. Based on the supporting information, what are the cons/weaknesses of the method?

In general the method is written clearly and concisely. However the use of A type PAC is incorrect because the DMAC reagent reacts with all PACs and it is misleading the state that the method is specific to A type PACs from cranberries.

The DMAC method is a rapid method that has great potential for use in standardizing PAC content in products.The use of H2SO4 and methanol appears to be a valid modifications of the original method but needs to validated.

The problem of accuracy and appropriate standards is a serious constraint. The method is non-specific and therefore an alternative method for identification of A type PACs is required as requested in AOAC SMPR® 2017.004

7. Any general comments about the method?

The modified method is worthy of further consideration but the use of appropriate standards has to be addressed.

Recommendation for the Method

V. Final Recommendation Do you recommend this method be adopted as a First Action and published in the Official Methods of Analysis of AOAC INTERNATIONAL? Please specify rationale.

No, the authors overlooked and do not discuss the problem of appropriate standards and failed to reference Feliciano et al (2012).