AOAC2016-03ERPRECOMMENDATION
SPIFAN Expert Review Panel Report September 29, 2015 Final Version
IV. REVIEW OF METHODS BY EXPERT REVIEW PANEL (ERP) FOR FINAL ACTION OFFICIAL METHOD SM STATUS The Expert Review Panel (ERP) reviewed Two (2) methods for Final Action Official Methods SM status. Zero (0) methods were recommended to the Official Methods Board (OMB) for Final Action Official Method SM consideration.
Method Title
Reviewer(s) Sneh Bhandari Brendon Gill/
Vote
Comments
Method
Copper did not meet SMPR for LOQ Clarification on LOQ Need diversity of infant formula Need justification from ERP on SMPR
OMA# 2011.14 (MTE-01) - 2013 AOAC INTERNATIONAL AOAC Official Method 2011.14 Calcium, Copper, Iron, Magnesium, Manganese, Potassium, Phosphorus, Sodium, and Zinc in Fortified Food Products
Bill Mindak (Moved) Brendon Gill (Second) Motion: withdrawn _________________ Method not recommended Action Official Method SM status with a change in the applicability for infant formula Jon DeVries (Moved) Sarwar Gilani (Second) Yes-2/ No-11/Abstain-2 _________________ Method not recommended for Final Action status *Method retains First Action Official Method SM status for Final Action status *Method retains Final
Minerals & Trace Elements
Harvey Indyk Don Gilliland
Only one (1) sample was used for D 2 Exclude HPLC 8/16 had performance issues Next steps o Open call for methods o Discuss with stakeholders
Vitamin D OMA# 2011.11 (VitD-01) - Vitamin D - Determination of Vitamin D2 and D3 in Infant and Adult/Pediatric Nutritionals and Utilizing Ultra High Performance Liquid
Sneh Bhandari Brendon Gill/ Harvey Indyk
Chromatography/Tandem Mass Spectrometry (UHPLC- MS/MS)
IV. REVIEW OF METHODS BY EXPERT REVIEW PANEL (ERP) FOR REPRODUCIBILITY TESTING The ERP will collectively discuss the methods and select a single method to move forward through the AOAC SPIFAN process for reproducibility testing.
Method Evaluation Forms - Methods processed via the numbering system:
Method Title
Number Voting
Comments
Method
OMA# 2014.04 ( Car n-05) - Single Laboratory Validation of CARN-05: Determination of Free and Total Carnitine and Choline in Infant Formulas and Adult Nutritional Products OMA# 2015.10 ( Car n-07) - Analysis of Free and Total Carnitine and Choline in Infant Formula and Adult Nutritionals OMA# 2015.08 (Chlor-02) - Infant Formula and Adult Nutritionals Chloride by Potentiometry OMA# 2015.07 (Chlor-04) Chlorine in Infant Formula and Adult/Pediatric Nutritional Formula by Potentiometric Titration OMA# 2013.13 (Fol-21) - Single-Laboratory Validation - Free Folates in Infant Formula and Adult/ Pediatric Nutritional Formula by UHPLC-UV
Carnitine/ Choline
1204
~Move to reproducibility testing
1207
CAIQ & Nestle to work together to get one method
Chloride
~Move to reproducibility testing
1413
1411
No Vote
Method doesn't do bound folate Nestle & Silliker to work together and write up a document explaining - should harmonize. Exact match label compound define "total" If you leave in "use internal standard" remove the compound Defer to March 2016
Folate
69
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