August 30, 2016 SPADA Meeting Book

Background

Detection

St t l ruc ura  element

Functional

• Relatively easy to detect • Presence or absence • Often qualitative • Cost‐effective

• Relatively Not‐easy to detect • Active or inactive • Qualitative and quantitative • Expensive • Representative of BoNT intoxication 

SMPR Key Points

• Botulinum 

• Subtypes A2‐A8;  degree of confidence  ( dd ) a ress in SMPR • Characterization of B‐ G

neurotoxin type A

• Field deployable  assay • Complexities in  detecting di‐chain  and complex toxins, 

culture filtrates