August 30, 2016 SPADA Meeting Book
Background: Poxvirus 101
Family of large, double stranded DNA viruses Within genera, antigenic similarity: t ti cross pro ec on Complex viruses, cytoplasmic lifecycle Genus Orthopoxvirus: 90-98% nucleotide identity across species V i l V i i C ar o a, acc n a, owpox, Monkeypox – all can cause human disease • Variola evolved to be a sole human pathogen: SMALLPOX
Camelpox, Ectromelia, Taterapox are NOT known to cause human disease
Objectives
• Smallpox introduction
• Development of smallpox clinical diagnostics
• Developing a framework for considering environmental smallpox detection/testing
– Results of 2016 Standard Method Performance Requirements for Detection of Variola virus DNA in collection buffers from aerosol collection devices for DoD applications
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