August 30, 2016 SPADA Meeting Book

Source: Breman JD, Henderson DA. N Engl J Med 2002;346:1300-8.

Progression of Smallpox

• Incubation Period • Pre-eruptive Stage: – abrupt onset high fever/constitutional symptoms

• Macules • Papules • Vesicles • Pustules

• Scabs • Scars