Candidates for 2016 ERP of the Year

ERP PROFILE SUMMARIES

SPIFAN Expert Review Panel Report March 19, 2014 Final

I.

WELCOME AND INTRODUCTIONS Darryl Sullivan welcomed all participants to the ERP meeting and introduced the ERP members.

II.

REVIEW ACTIONS FROM PREVIOUS MEETING Darryl Sullivan reviewed previous actions/items from past meetings.

III. REVIEW OF METHODS BY EXPERT REVIEW PANEL (ERP) FOR FIRST ACTION OFFICIAL METHOD SM STATUS For each method, the ERP/Working Group Co-Chairs discussed methods submitted.

Carnitine – Co‐Chairs: John Austad (Covance) & Guenther Raffler (CLF-Eurofins) Choline – Co‐Chair: Sneh Bhandari (Silliker) & Nick Cellar (Abbott)

To study directors, methods should be able to detect both carnitine and choline, but evaluate the methods independently.

IV.

REVIEW OF MODIFICATION FOR OMA# 2011.08 (Vitamin B 12 )

V. The Expert Review Panel (ERP) reviewed the modification to OMA method 2011.08. The primary (Christiansen/Sliva) and secondary (Kneeteman) reviewers provided their evaluation along with other members of the ERP.  This is a new method, it contains significant changes. Should check if it should be major or minor modification  For AOAC First Action, the method must have SPIFAN SLV data  For publication, reference the previous method  Vote the current modified method as AOAC First Action  HPLC/ULC – have data reflect both HPLC & ULC  Have a dispute resolution method, but keep as a back-up  Caveat – back up method if study director doesn’t want to continue  Re-introduce as a new method

VI.

REPEAL OF FIRST ACTION METHODS The Expert Review Panel (ERP) members collectively discussed the next steps on the remaining First Action Official Methods SM currently in the SPIFAN system.

Method

Method Title

Reviewer(s)

Vote

Comments

Folate

2011.05 - Folate in Infant Formula and Adult/Pediatric Nutritional Formula Optical Biosensor Assay

Sneh Bhandari Melissa Phillips

*Motion to repeal Yes- 11/ No-0 /Abstain-1

Method is being used, but no SLV data to be produced

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2011.06 - Total Folates in Infant Formula and Adult Nutritionals by Trienzyme Extraction and UPLC- MS/MS Quantitation: First Action 2011.06

Adrienne McMahon Matt Sliva for Scott Christiansen

*Motion to extend method for one (1) year Yes- 10/ No-0 /Abstain-1

No further work will be done Extend method for one(1) year If method is kept, someone should take it on 1 st Action status should have meaning o Proprietary method (single source)

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Nucleotides

2011.21 - Development and Application of an HILIC-MS/MS Method for the Quantitation of Nucleotides in Infant Formula

Estela Kneeteman Min Huang

*Motion to keep Yes- 11/ No-0 /Abstain-1

Keep as a back-up method

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