Carn-06_Book_Final

Carn-06 (Choline Validation Report-Addendum) FOR ERP USE ONLY DO NOT DISTRIBUTE

Abbreviations and synonyms:

Abbreviations: NMKL.................Nordisk Metodikk Komité for Næringsmidler ISO ....................International Organization for Standardization SOP...................Standard Operating Procedure ANAVA ..............Analysis of Variance n ........................Number of replicates RSD%................Relative Standard Deviation in Percent CI .......................Confidence intervals S r .......................Repeatability (standard deviation within days) S R ......................Reproducibility (standard deviation between days) Synonyms: t-test .................. Student’s t -test This validation report is conducted in accordance to our internal instruction 211.01 “Validering af analysemetoder i Vitamin center (in English - Validation of analytical methods in the Vitamin Centre” This instruction defines the experimental design used in the current validation, which is based on NMKL Procedure No. 4: Validation of chemical analytical methods (2009, 3 rd edition). The Eurofins Steins Laboratory in Vejen is accredited according to ISO 17025. Quality statement:

Introduction:

The choline method has been employed on the SPIFAN test kit to investigate the methods capabilities on this set of samples.

Statistics:

In the current validation report, a p-value < 0.05 is considered statistically signifi- cant. Consequently, confidence intervals (CI) are calculated at a confidence level at 95 %. Paired t-testing is performed on normal distributed raw data. Data which is not within the normal distribution is clearly marked within the text.

Matrices:

The SPIFAN test kit consists of 17 samples providing a representative collection

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