Chemistry-PTM-OMA_Modules_1-4

Limit of Detection (LOD) and  Limit of Quantitation (LOQ) Limit of Detection (LOD)

• The measured quantity value, obtained by a given measurement  procedure, for which the probability of falsely claiming the absence of  a component in a material is β, given a probability α of falsely  claiming its presence • IUPAC recommends default values for αand β equal to 0.05 (or 95%  confidence) Limit of Quantitation (LOQ), also called Limit of Determination • The lowest amount of analyte in a laboratory sample which can be  quantitatively determined with a defined confidence (predetermined  goals for bias and imprecision are met)