ISO_NWIPs-for-Ballot

ISO/NP

Introduction 25 Quantitative analysis using nuclear magnetic resonance (NMR) spectroscopy has been used since the 26 1960s by researchers in many countries. However, it was not used as a general measuring procedure, 27 since a practical method for such quantitative analysis was not established. 28 Both the NMR equipment and the computers for data processing have dramatically advanced in their 29 performances since around the year 2000, which has made the quantification by NMR possible[see ref. 30 23]. 31 For preparation of this document, the NMR equipment, optimization of a measuring specification, and 32 data analysis and automation have been considered. Research and development have been carried out 33 for reference materials suitable for 1 H nuclei which do not interfere with the quantitative analysis of an 34 analyte, and for a method to obtain an analytical value for organic compounds for which traceability to 35 the International System of Units (SI) has been established. 36 On this basis, the purity and the content of organic compounds can now be measured using a 37 conventional method. This helps obtain rapid results and reliable analytical values for analytes in 38 chemicals, medical supplies, unregulated drugs and foodstuffs [see ref. 2, 3 and 12]. 39

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