Expert Review Panel for Dietary Supplements

4. Based on the supporting information, is the method written clearly and concisely? If no, please specify the needed revisions. 5. Based on the supporting information, what are the pros/strengths of the method?

Yes

The method performs well for most of the matrices examined.

The RSDr for Coffee Extract and Cocoa Extracts were out of the range listed on the SMPR. It was noted on the Cocoa Extract was likely below the limit of quantitation.

Recovery fell within the ranges of the performance requirements.

6. Based on the supporting information, what are the cons/weaknesses of the method?

This is not a comment on the specific method and instead a comment on the use of method dependent "total phenolic" determinations. As the community is moving away from the use of these methods and the meaning of the results, does the AOAC want to pursue first action methods in this category?

7. Any general comments about the method?

No

Recommendation for the Method

V. Final Recommendation Do you recommend this method be adopted as a First Action and published in the Official Methods of Analysis of AOAC INTERNATIONAL? Please specify rationale.

If the AOAC wants to move forward with this type of method (a total phenolic method) then this method should be tested with raw plant materials and solid oral dosages in order to represent the raw materials and final products as stated in applicability. I would also recommend that the method should be tested more with products at the extreme high and low ends and possibly with systematic sample types (varying the matrix effects) to see if there is a pattern to where the method meets the RSDr in the SMPR and where it does not.