Quant. MAC Working Group Meeting Book (March 13, 2019)

AOAC Annual Meeting 2018

• The two step approach allows for secondary evaluation of the method in cases of non- homogeneity of the sample based on the reference method

AOAC Annual Meeting 2018

1.1

bias β-ETI lower β-ETI upper

0.0

0

1

2

3

4

5

6

AL AL

ALs ALs

-1.1

Comparison

y = 0.9933x - 0.01

Large s for alternative and reference. No bias.

0.0 1.0 2.0 3.0 4.0 5.0 6.0

Initial AP Æ reject Current AP Æ accept

Alternative

0.0

1.0

2.0

3.0

4.0

5.0

6.0

Reference