Quant. MAC Working Group Meeting Book (March 13, 2019)

November 2018: Conference Call • Update on ISO WG2 Meeting • Accuracy Profile based on 95% CI +/- 0.5 Log • Allowed to expand if s of reference method is greater than 0.125 Log (indicates samples are not homogenous) • Calculate new 95% CI at 4x the s of the reference method • Unable to evaluate AOAC data using ISO Workbook • Workbook is designed to evaluate 10 test replicates per contamination level. • AOAC evaluations contain 5 test replicates per contamination level November 2018: Conference Call • Follow Up Items: • Evaluate the potential of using a modification of the ISO Acceptance Criteria. • Use a combination of the 2 tiered approach and take whichever value is greater • AL = 0.5 or 4x the s of the reference method • Reactivate the ISPAMWG on statistics