ISPAM Working Group Chair Presentation Book

Bioassay Based on PDE5 Inhibition • Screening based on the common mode of action of  PDE5 inhibitors • Bioassays developed for screening of suitable drug  candidates to detect their inhibition activity Examples:  ‐ PDE Glo TM (Promega) ‐ homogenous bioluminescent cAMP‐ PDE/cGMP‐PDE assay  ‐ PDE5A Assay Kit (BPS Bioscience) – fluorescence‐based  GMP PDE5A c ‐  assay