ISPAM Working Group Chair Presentation Book

Nuclear Magnetic Resonance (NMR) f l f l d • Power u or structure e uci ation

• Technological advances (new NMR experiments  and data processing tools) improved sensitivity and  enabled measurements in solutions • Diffusion ordered spectroscopy (DOSY) NMR  b d d ff ff ll – separation ase on i usion coe icients, a owing  fingerprinting of active ingredients and excipients • Potential for screening, identification, and  quantitation of adulterants Examples: l l h d l ( ) ‐ Ba ayssac et a ., J. P arm. Biome . Ana . 50 2009 602–612. ‐ Silva et al., Magn. Reson. Chem. 51 (2013) 169‐176