ISPAM Working Group Chair Presentation Book

Phosphodiesterase Type 5 (PDE5) Inhibitors

• Used in the treatment of erectile dysfunction (ED) and also  explored for the treatment of pulmonary hypertension  • Block degradative action of PDE5 on cyclic guanosine monophosphate (cGMP) in smooth muscle cells lining the  blood vessels supplying the corpus cavernosum of the  penis (and arterial walls within the lungs)

cGMP

• cGMP = second messenger relaxing smooth muscle tissues ,  leading to the increased blood flow in blood vessels