July 2019 PAC ERP Review Book

PAC Method Re-submission Review Form Submission Date

2019-07-05 06:17:14

Name

Tomasz Tuzimski

Email

tomasz.tuzimski@umlub.pl

Organization

Medical University of Lublin, Poland

Candidate Method Number:

PAC-02

Yes

Please provide justification for your answer. If specific requirements were made in the December 17, 2017 meeting, please explain how those requirements have been met or not met. Has the resubmitted method met the requirements outlined on December 15, 2017?

The proposed (resubmitted) method entitled ‘PAC‐02: Multi‐laboratory validation of 4‐(dimethylamino)cinnamaldehyde (DMAC) assay using cranberry proanthocyanidin standard for quantification of soluble proanthocyanidins in cranberry foods and dietary supplements’ described by Christian Krueger - is met the requirements outlined on December 15, 2017. The developed method was evaluated following the definitions of AOAC SMPR® 2017.003 with respect to Linearity, Repeatability, Reproducibility, Recovery, LOQ values. My remarks to the proposed method are as follows: Lines 315, 316, Table 2. Calibration curves of ProA2 and c-PAC standards: Could Authors add standard deviations of the 'Slope' and 'Intercept' in equations of the regression lines?