KRA-01
FDA/ORA/ORS
LIB #4578 21 of 25
Figure 17: a) Positive Control - Total Ion Chromatogram (TIC)
b) Positive Control - Reconstructed Ion Chromatogram (RIC)
Kraton_27Dec12_A14 - TIC - SM: 5 RT: 5.00 - 14.99
NL: 2.12E6
RT: 11.51
10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95 100 Relative Intensity
a
RT: 12.26
RT: 12.79
RT: 13.25
0 5
13.55 14.11 14.70
5.31
6.09
6.98
7.66
8.42
9.07
9.56
RT: 10.24
11.03
6
7
8
9
10
11
12
13
14
Time (min)
RT: 9.86 - 14.99
RT: 10.50 - 15.00
RT: 11.55
NL: 1.78E6 TIC F: + c ESI SRM ms2 399.200 [159.099-159.101, 174.099-174.101, 238.199-238.201] MS ICIS kraton_28dec12_a15
RT: 11.55
NL: 7.99E5 m/z= 173.90-174.10 F: + c ESI SRM ms2 399.200 [159.099-159.101, 174.099-174.101, 238.199-238.201] MS ICIS kraton_28dec12_a15
100
10 20 30 40 50 60 70 80 90 100
95
b
90
SRM 399.1 -> 174 Positive Control Mitragynine Rt=11.53
85
80
RT: 12.29
75
Total Ion Chromatogram (TIC) Postive Control Mitragynine Rt=11.53
RT: 12.80
70
10 20 30 40 50 60 70 80 90 100 Relative Abundance 0
NL: 5.09E5 m/z= 159.00-159.20 F: + c ESI SRM ms2 399.200 [159.099-159.101, 174.099-174.101, 238.199-238.201] MS ICIS kraton_28dec12_a15
RT: 11.55
65
60
SRM 399.1 -> 159.1 Positive Control Mitragynine Rt=11.53
55
50
RT: 12.29
45
Relative Abundance
40
RT: 12.82
35
0 10 20 30 40 50 60 70 80 90 100 0
RT: 12.29
RT: 11.53
NL: 4.78E5 m/z= 238.00-238.20 F: + c ESI SRM ms2 399.200 [159.099-159.101, 174.099-174.101, 238.199-238.201] MS ICIS kraton_28dec12_a15
30
25
SRM 399.1 -> 238.1 Positive Control Mitragynine Rt=11.53
20
15
RT: 12.27
10
RT: 12.82
5
RT: 12.82
RT: 13.56
RT: 14.64
0
10
11
12
13
14
11
12
13
14
15
Time (min)
Time (min)
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