Micro December 2018

1 Table 16: Robustness study: Mean differences (log 10 ) and 95% confidence intervals between each treatment combinations and 2 the nominal test condition 3

Treatment combination a

Target Analyte

Inoculation Non-Target Organism c

1

2

3

4

N/A d

N/A

N/A

N/A

Klebsiella oxytoca (ATCC b 51817)

-0.0110 (-0.0962, 0.0743) -0.0826 (-0.1680, 0.0029)

0.0011 (-0.0690, 0.0711) 0.0371 (-0.0441, 0.1184)

0.0723 (-0.0021, 0.1468) 0.0673 (-0.0251, 0.1597)

0.1111 (0.0314, 0.1908) 0.0913 (0.0091, 0.1735)

Low Level

High Level

Non-Target Organism

N/A

N/A

N/A

N/A

E. coli (ATCC 8739)

0.0102 (-0.1522, 0.1726) 0.0091 (-0.0530, 0.0711)

0.0424 (-0.1346, 0.2194) 0.0606 (-0.0176, 0.1389)

0.0880 (-0.0268, 0.2027) 0.0524 (-0.0330, 0.1378)

0.1333 (0.0218, 0.2448)

Low Level

High Level 0.1163 (0.0534, 0.1793) a Treatment combinations: 1) 0.9 mL sample volume, 16 h incubation time; 2) 0.9 mL sample volume, 28 h incubation time; 3) 1.1 mL sample volume, 16 h 4 incubation time; 4) 1.1 mL sample volume, 28 h incubation time. Nominal test condition: 1.0 mL sample volume, 18–24 h incubation time. 5 b ATCC: American Type Culture Collection, Manassas, VA. 6 c Staphylococcus aureus ATCC 6538. 7 d N/A: Not applicable. Non-target organism was not detected, producing an enumeration of <1.

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