Microbiology-PTM-OMA_Modules_1-5

Analyzing Data – Qualitative Method SLV • Method comparison achieved by estimating bias of candidate method • Bias estimated as dPOD, the difference between two POD values • dPOD CP = POD CP – POD CC = bias between presumptive and confirmatory results of  the candidate method • dPOD C = POD C – POD R = bias between candidate and reference method results • Calculate 95% confidence intervals on dPOD values • Calculation depends on whether comparison is paired or unpaired • If the confidence interval on dPOD does not contain zero, then the two  POD values are statistically different (bias is significant).