Microbiology-PTM-OMA_Modules_1-5

Overview • This study evaluates the ability of the method to remain unaffected by  small variations in method parameters that might be expected to occur  when the method is performed by an end user. • The method developer, in conjunction with the AOAC Project Manager, is  expected to make a good faith effort to choose parameters that can be  influenced by the end user and are most likely to affect the analytical  performance and determine the range of variation that can occur without  adversely affecting the analytical results • Parameters are varied and deviations tested in a factorial study and  compared to the baseline results of the test method. • 3 parameters, whenever possible, are chosen to be tested. • Results are compared to the baseline test results. • May utilize pure culture or may require inoculating a matrix depending on  parameters chosen.