Microsoft Word - Candidates for 2018 ERP of the Year

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Free Amino Acids:   Method Reviews and Decisions

AOAC  Method # 

Manuscript Title, Submitter and Reviewers 

RP Decisions / Consensus 

Title:   Free Amino Acid Profile and Absence  Verification Method by UPLC  Author(s): Phillip Haselberger, Abbott Nutrition  Submitted by: Phillip Haselberger, Abbott Nutrition Primary Reviewer:   Garrett Zielinski, Covance Laboratories Secondary Reviewer:   Holly Johnson, Alkemist  Labs

MOTION not to move this method to First Action Official Methods of Analysis ® Status (Johnson/Joseph)   8 in favor, 0 opposed, 1 abstention.  The motion carried.  Reasoning/Summary: Although the ERP members stated that this is a  good method, the members agreed that more compounds should be  tested prior to approval as a First Action Official Method of Analysis.   Specifically, the author should provide:  Data must demonstrate ability to identify and quantitate the  free amino acids in Table 1 in the presence of the non‐target  compounds of interest in Table 5 of SMPR 2017.011.   Clarify the scope – what type of samples is this applicable to?     Clarify the sample prep of the different matrices.     Linearity should be demonstrated with five‐point validation.   Accuracy/Recovery data for ensuring full derivatization.    Data demonstrating stability of the derivative amino acids  standards and samples.

                 FAA‐001

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03/12/2018